| Local recurrence | Any second breast cancer | ||
---|---|---|---|---|
 | RRa | 95% CIb | RRa | 95% CIb |
Univariate models | ||||
Diagnosis year | Â | Â | Â | Â |
   1990-1991 | 1.0 | (reference) | 1.0 | (reference) |
   1992-1993 | 0.7 | 0.5-1.0 | 0.8 | 0.6-1.1 |
   1994-1995 | 0.8 | 0.6-1.2 | 0.9 | 0.6-1.2 |
   1996-1997 | 0.7 | 0.5-1.0 | 0.7 | 0.5-0.9 |
   1998-1999 | 0.4 | 0.3-0.6 | 0.4 | 0.3-0.6 |
 | P for trend < 0.0001 | P for trend < 0.0001 | ||
Adjuvant therapy | Â | Â | Â | Â |
   None (BCSc only) | 1.0 | (reference) | 1.0 | (reference) |
   Radiotherapy | 0.4 | 0.3-0.5 | 0.6 | 0.5-0.7 |
   Tamoxifen | 0.1 | 0.04-0.6 | 0.2 | 0.1-0.6 |
   Radiotherapy+Tamoxifen | 0.1 | 0.05-0.4 | 0.3 | 0.1-0.5 |
Multivariable model (with treatment variables) | ||||
Diagnosis year d | Â | Â | Â | Â |
   1990-1991 | 1.0 | (reference) | 1.0 | (reference) |
   1992-1993 | 0.8 | 0.6-1.2 | 0.9 | 0.7-1.3 |
   1994-1995 | 1.0 | 0.7-1.4 | 1.0 | 0.7-1.3 |
   1996-1997 | 0.8 | 0.6-1.2 | 0.8 | 0.6-1.1 |
   1998-1999 | 0.6 | 0.4-0.8 | 0.6 | 0.4-0.8 |
 | P for trend = 0.008 | P for trend = 0.0002 | ||
Adjuvant therapy | Â | Â | Â | Â |
   None (BCSc only) | 1.0 | (reference) | 1.0 | (reference) |
   Radiotherapy | 0.4 | 0.3-0.6 | 0.6 | 0.5-0.8 |
   Tamoxifen | 0.2 | 0.04-0.7 | 0.2 | 0.1-0.7 |
   Radiotherapy+Tamoxifen | 0.2 | 0.06-0.4 | 0.3 | 0.2-0.6 |