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Figure 2 | Breast Cancer Research

Figure 2

From: Genetic variation in insulin-like growth factor signaling genes and breast cancer risk among BRCA1 and BRCA2 carriers

Figure 2

Haplotype presence for insulin-like growth factor binding proteins. Estimated hazard ratios (Est HR) associated with haplotype presence for (a) insulin-like growth factor binding protein (IGFBP)-1, (b) IGFBP2, and (c) IGFBP5. Linkage blocks were defined as pairwise linkage disequilibrium coefficient D' ≥ 0.90. Estimates were stratified by BRCA status (left column, BRCA1; right column, BRCA2) and adjusted for birth cohort and ethnicity as well as first pregnancy, prophylactic oophorectomy, and diagnosis of ovarian cancer as time-dependent covariates. LD Grp, linkage disequilibrium group; Geno/Haplo, genotype/haplotype; Freq, frequency.

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Breast Cancer Research

ISSN: 1465-542X

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