Figure 3From: The membrane mucin MUC4 is elevated in breast tumor lymph node metastases relative to matched primary tumors and confers aggressive properties to breast cancer cellsMUC4 expression is consistently suppressed in the normal-to-tumor transition. (a) Lysates from eight patient-matched normal and tumor tissue samples, four representing grade II tumors and four representing grade III tumors, were immunoblotted with 1G8s and anti-actin (right panels). Pathology analysis of patient tumor samples, including estrogen receptor (ER), progesterone receptor (PR) and human eipdermal growth factor receptor (HER) 2 status, are provided in the table. (b) Lysates from six independent patient-matched normal and tumor tissues were analyzed side by side with JIMT-1 cell lysates.Back to article page