| Adjustmenta | ||
---|---|---|---|
 | Age and batch | Age, batch and BMI | Age, batch, BMI and breast cancer risk factorsb |
Plasma biomarkerc | Â | Â | Â |
   Leptin (ng/ml)d | 6.8 (4.8, 8.9)**** | 3.2 (1.7, 4.7)**** | 3.6 (1.9, 5.2)**** |
   Oestradiol (pmol/l) | 1.31 (1.12, 1.52)**** | 1.11 (0.96, 1.29) | 1.11 (0.94, 1.31) |
   Free oestradiol (pmol/l) | 1.39 (1.17, 1.65)**** | 1.11 (0.95, 1.30) | 1.11 (0.94, 1.32) |
   Oestrone (pmol/l) | 1.13 (1.01, 1.27)** | 1.05 (0.93, 1.18) | 1.05 (0.93, 1.19) |
   SHBG (nmol/l) | 0.86 (0.78, 0.96)*** | 0.98 (0.89, 1.08) | 0.96 (0.86, 1.07) |
   Testosterone (nmol/l) | 0.94 (0.80, 1.11) | 0.88 (0.74, 1.03) | 0.86 (0.72, 1.03) |
   Prolactin (mIU/l) | 1.02 (0.90, 1.16) | 1.04 (0.91, 1.19) | 1.00 (0.87, 1.16) |
   IGF-I (ng/ml) | 1.09 (1.00, 1.19)** | 1.13 (1.03, 1.24)*** | 1.12 (1.01, 1.24)** |
   IGF-I:IGFBP-3 molar ratio | 1.13 (1.04, 1.23)*** | 1.20 (1.10, 1.30)*** | 1.20 (1.10, 1.32)*** |
   IGF-II (ng/ml) | 0.83 (0.77, 0.89)**** | 0.82 (0.76, 0.89)**** | 0.82 (0.76, 0.90)**** |
   IGF-II:IGFBP-3 molar ratio | 0.86 (0.80, 0.92)**** | 0.87 (0.81, 0.94)** | 0.89 (0.82, 0.96)** |
   IGFBP-3 (ng/ml) | 0.96 (0.91, 1.02)* | 0.94 (0.89, 1.00)** | 0.93 (0.87, 0.99)** |
Mammographic measurese | Â | Â | Â |
   Mammographic density (%) | -5.4 (-7.8, -3.0)**** | -2.5 (-5.1, 0.2)* | -0.8 (-3.7, 2.2) |
   Dense area (cm2) | -2.7 (-6.9, 1.4) | -1.9 (-6.4, 2.7) | 0.7 (-4.4, 5.8) |
   Nondense area (cm2) | 50.5 (33.2, 67.8)*** | 19.6 (7.7, 31.5)*** | 15.7 (3.1, 28.3)** |
   Total breast area (cm2) | 48.7 (31.3, 66.0)**** | 18.7 (6.3, 31.1)*** | 17.0 (3.6, 30.5)** |