Table 6 Correlation of mouse mammary stem-like gene expression and published breast tumor lung metastasis signatures
Lung metastasis signature: 14 genes, nine of which (64%) changed in stem-like stage | ||
|---|---|---|
High at stem-like stage (9 genes) | Low at stem-like stage (0 genes) | Unchanged (5 genes) |
Id1 – regulation of transcription | Kynu – metabolic process | |
Tnc – cell adhesion | Man1a1 – metabolic process | |
Ly6ea – cell surface receptor-linked signal transduction | Vcam1 – membrane to membrane docking | |
Ltbp1 – growth factor binding | Cxcr4 – apoptosis | |
Angptl4a – regulation of apoptosis | Nedd9 – cell cycle/cell adhesion | |
Ptgs2 – regulation of cell proliferation | ||
Cxcl1 – negative regulation of cell proliferation | ||
Ereg – regulation of mitosis | ||
Fscn1 – cell proliferation | ||