Figure 3From: Recent advances in systemic therapy. New diagnostics and biological predictors of outcome in early breast cancerMultifactorial regulation of topoisomerase IIa (TopoIIa). TopoIIa gene transcription is under control of gene signals and proliferative signals. Redox-sensitive protein complexes regulate mRNA half-life. Variable mRNA splicing produces protein isoforms: the cytoplasmic form is inactive, the nuclear form is active. Nuclear receptors regulate transport of these isoforms depending on the cell proliferative phase [43].Back to article page