From: Comparison of molecular phenotypes of ductal carcinoma in situand invasive breast cancer
 | Eligible for TMA (n = 5610) | Received pathology specimens (n = 3752) | Included in TMA (n = 2897) |
---|---|---|---|
Means | Â | Â | Â |
Age at diagnosis, y | 56.4 | 57.4 | 57.5 |
Age at menarche, y | 12.4 | 12.4 | 12.4 |
Age at first birth, y | 25.4 | 25.4 | 25.3 |
Age at menopause, y | 46.9 | 47.1 | 47.1 |
BMI at age 18, kg/m2 | 21.0 | 21.0 | 21.0 |
Parity | 3.2 | 3.2 | 3.2 |
Alcohol g/week | 6.6 | 6.1 | 6.2 |
Frequencies, n (%) | Â | Â | Â |
Family history of BC | 805 (14.4) | 559 (14.9) | 409 (14.1) |
Nulliparous | 430 (7.7) | 281 (7.5) | 211 (7.3) |
Premenopausal | 1345 (24.0) | 782 (20.8) | 600 (20.7) |
Prior BBD | 2662 (47.5) | 1852(49.4) | 1360 (47.0) |
Current PMH user | 1239 (33.8) | 884 (34.2) | 688 (34.6) |
Year of diagnosis | Â | Â | Â |
1976 to 1980 | 517 (9.4) | 223 (6.1) | 158 (5.6) |
1980 to 1985 | 1066 (19.4) | 565 (15.4) | 431 (15.2) |
1985 to 1990 | 1678 (30.6) | 1152 (31.3) | 899 (31.6) |
1990 to 1996 | 2230 (40.6) | 1739 (47.3) | 1357 (47.7) |
Tumour characteristics a | Â | Â | Â |
DCIS | 654 (11.7) | 443 (11.8) | 270 (9.3) |
Invasive | 4956 (88.3) | 3309 (88.2) | 2627 (90.7) |
Tumour size | Â | Â | Â |
Less than 2 cm | 3162 (65.6) | 2197 (66.7) | 1685 (64.9) |
More than 2 cm | 1656 (34.4) | 1098 (33.3) | 911 (35.1) |
Grade | Â | Â | Â |
Well differentiated | 319 (15.2) | 240 (16.2) | 176 (14.7) |
Moderately | 860 (41.0) | 630 (42.4) | 515 (43.1) |
Poorly | 919 (43.8) | 615 (41.4) | 505 (42.2) |
Nodal involvement | Â | Â | Â |
No nodes | 3931 (70.1) | 2684 (71.5) | 2006 (69.2) |
1 to 3 nodes | 904 (16.1) | 585 (15.6) | 485 (16.7) |
4 to 9 nodes | 428 (7.6) | 268 (7.1) | 213 (7.4) |
More than 10 nodes | 228 (4.1) | 140 (3.7) | 129 (4.5) |
Metastatic | 119 (2.1) | 75 (2.0) | 64 (2.2) |
Receptor status | Â | Â | Â |
ER+ | 2738 (74.5) | 1953 (75.2) | 1572 (75.3) |
PR+ | 2083 (61.2) | 1518 (61.9) | 1235 (62.3) |