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Table 5 Associations between ERBB2 and AP-2α and/or YY1 levels (immunohistochemistry) in the FISH-negative group

From: The combined immunodetection of AP-2α and YY1 transcription factors is associated with ERBB2 gene overexpression in primary breast tumors

  

ERBB2 expression (percentage)

 
 

n

0/1+

2+

3+

P value

AP-2α expression

       

<0.001

   Low

18

14

(78)

4

(22)

0

(0)

 

   High

16

2

(12)

11

(69)

3

(19)

 

YY1 expression

       

0.106

   Low

16

10

(63)

6

(37)

0

(0)

 

   High

18

6

(33)

9

(50)

3

(17)

 

Combination

       

0.015

   AP-2α lo/YY1 lo

13

10

(77)

3

(23)

0

(0)

 

   AP-2α lo/YY1 hi or AP-2α hi/YY1 lo

8

4

(50)

4

(50)

0

(0)

 

   AP-2α hi/YY1 hi

13

2

(15)

8

(62)

3

(23)

 
  1. AP-2α, activator protein 2 alpha; FISH, fluorescent in situ hybridization; hi, high expression; lo, low expression; YY1, Yin Yang 1.
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Breast Cancer Research

ISSN: 1465-542X

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