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Figure 5 | Breast Cancer Research

Figure 5

From: Derlin-1 is overexpressed in human breast carcinoma and protects cancer cells from endoplasmic reticulum stress-induced apoptosis

Figure 5

Effects of derlin-1 knockdown on endoplasmic reticulum stress-induced apoptosis. (a) Western blot analysis of derlin-1 and GRP78 in non-treated or thapsigargin (TG)-treated SKBR-3 cells that were transfected with or without small interfering RNA (siRNA). (b) The percentage of apoptosis in non-treated, TG-treated, and staurosporine-treated SKBR-3 cells that were transfected with siCtrl or siDerlin-1. Columns indicate the mean of three experiments; bars indicate the standard error. (c) Western blot analysis of GRP78 in vehicle-treated, staurosporine-treated, and thapsigargin-treated cells. siCtrl, control small interfering RNA; siDerlin-1, derlin-1 small interfering RNA.

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Breast Cancer Research

ISSN: 1465-542X

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