From: Aging impacts transcriptomes but not genomes of hormone-dependent breast cancers
UniGene symbol | Fold changea | UniGene name |
---|---|---|
Genes with higher expression in the young cohort | ||
   AREGb | 3.12 | Amphiregulin (schwannoma-derived growth factor) |
   PRSS2b | 2.71 | Protease, serine, 2 (trypsin 2) |
   GREB1b | 2.34 | GREB1 protein |
   PTHLHb,d | 2.01 | Parathyroid hormone-like hormone |
   HPGDc | 1.98 | Hydroxyprostaglandin dehydrogenase 15-(NAD) |
   SPANXA1///SPANXB1///SPANXA2///SPANXCc///SPANXB2 | 1.91 | Sperm protein associated with the nucleus, X-linked, family member A1///SPANX family, member B1///SPANX family, member A2///SPANX family, member C///SPANX family, member B2 |
   LAMA3d | 1.87 | Laminin, alpha 3 |
   ATP6V1B1c | 1.82 | ATPase, H+ transporting, lysosomal 56/58 kDa, V1 subunit B, isoform 1 (renal tubular acidosis with deafness) |
   S100A2b,d | 1.79 | S100 calcium binding protein A2 |
   DIO2c | 1.79 | Deiodinase, iodothyronine, type II |
   PRSS1b///PRSS2b///PRSS3///TRY6 | 1.77 | Protease, serine, 1 (trypsin 1)///protease, serine, 2 (trypsin 2)///protease, serine, 3 (mesotrypsin)///trypsinogen C |
   FGFR1b,d,e | 1.65 | Fibroblast growth factor receptor 1 |
   TP73Lb,d | 1.60 | Tumor protein p73-like |
   PRSS1b | 1.59 | Protease, serine, 1 (trypsin 1) |
   C20orf59 | 1.57 | Chromosome 20 open reading frame 59 |
   DLG7b,f | 1.56 | Discs, large homolog 7 (Drosophila) |
   ELOVL2c | 1.52 | Elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2 |
   KIF2Cb,f | 1.50 | Kinesin family member 2C |
   STK6b,f | 1.49 | Serine/threonine kinase 6 |
   USTc | 1.47 | Uronyl-2-sulfotransferase |
   CDC14Af | 1.42 | CDC14 cell division cycle 14 homolog A (S. cerevisiae) |
   ELL3c | 1.42 | Elongation factor RNA polymerase II-like 3 |
   RAD54Bc,f | 1.41 | RAD54 homolog B (S. cerevisiae) |
   ITGA2b,d,e | 1.33 | Integrin, alpha 2 (CD49B, α2 subunit of VLA-2 receptor) |
Genes with higher expression in the old cohort | ||
   HOXB6b,d | 2.40 | Homeobox B6 |
   TMC5 | 2.36 | Transmembrane channel-like 5 |
   HOXB2c,d | 1.99 | Homeobox B2 |
   ST6GALNAC5 | 1.99 | ST6 (α-N-acetyl-neuraminyl-2,3-β-galactosyl-1,3)-N-acetylgalactosaminide α-2,6-sialyltransferase 5///ST6 (α-N-acetyl-neuraminyl-2,3-β-galactosyl-1,3)-N-acetylgalactosaminide α-2,6-sialyltransferase 5 |
   KIAA1102 | 1.82 | KIAA1102 protein |
   PYGLc | 1.82 | Phosphorylase, glycogen; liver (Hers disease, glycogen storage disease type VI) |
   TNFSF10b | 1.82 | Tumor necrosis factor (ligand) superfamily, member 10///tumor necrosis factor (ligand) superfamily, member 10 |
   GOLPH2c | 1.78 | Golgi phosphoprotein 2 |
   DSPG3c | 1.75 | Dermatan sulfate proteoglycan 3 |
   GLRXc | 1.75 | Glutaredoxin (thioltransferase) |
   FLJ20152 | 1.73 | Hypothetical protein FLJ20152 |
   GATMc | 1.72 | Glycine amidinotransferase (l-arginine:glycine amidinotransferase) |
   ENTPD5b | 1.69 | Ectonucleoside triphosphate diphosphohydrolase 5 |
   SASH1b,f | 1.69 | SAM and SH3 domain containing 1 |
   ITPR1b | 1.68 | Inositol 1,4,5-triphosphate receptor, type 1 |
   ANGc,d,e///RNASE4 | 1.66 | Angiogenin, ribonuclease, RNase A family, 5///ribonuclease, RNase A family, 4 |
   IQGAP2b | 1.63 | IQ motif containing GTPase activating protein 2 |
   MANSC1 | 1.62 | MANSC domain containing 1 |
   HOXB5c,d,e | 1.60 | Homeobox B5 |
   FAHb | 1.60 | Fumarylacetoacetate hydrolase (fumarylacetoacetase) |
   ARHGDIBc,d | 1.60 | Rho GDP dissociation inhibitor (GDI) beta |
   TAPBPLc | 1.59 | TAP binding protein-like |
   CLMNc | 1.56 | Calmin (calponin-like, transmembrane) |
   ESR1b,d,e,f | 1.56 | Estrogen receptor 1 |
   EFNA1b | 1.56 | Ephrin-A1 |
   COBLL1 | 1.56 | COBL-like 1 |
   P8b,d,e | 1.55 | p8 protein (candidate of metastasis 1) |
   SC5DL | 1.52 | Sterol-C5-desaturase (ERG3 δ-5-desaturase homolog, fungal)-like |
   CLEC5A | 1.52 | C-type lectin domain family 5, member A |
   SEPT6f | 1.52 | Septin 6 |
   RHOBb,d,e,f | 1.52 | Ras homolog gene family, member B |
   CYB5 | 1.51 | Cytochrome b-5 |
   PDE4Ab | 1.50 | Phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila) |
   C21orf25 | 1.49 | Chromosome 21 open reading frame 25 |
   CCL3c///CCL3L1///CCL3L3 | 1.49 | Chemokine (C–C motif) ligand 3///chemokine (C–C motif) ligand 3-like 1///chemokine (C–C motif) ligand 3-like 3 |
   CCDC28A | 1.46 | Coiled-coil domain containing 28A |
   CALM3 | 1.46 | Calmodulin 3 (phosphorylase kinase, delta) |
   PPFIBP2c | 1.46 | PTPRF interacting protein, binding protein 2 (liprin β2) |
   DBIc | 1.46 | Diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein) |
   SLC25A12c | 1.45 | Solute carrier family 25 (mitochondrial carrier, Aralar), member 12 |
   CPMb,d,e | 1.44 | Carboxypeptidase M |
   MARCH8 | 1.43 | Membrane-associated ring finger (C3HC4) 8 |
   FLJ20298 | 1.41 | FLJ20298 protein |
   SLC12A8c | 1.40 | Solute carrier family 12 (potassium/chloride transporters), member 8 |
   FUCA1b | 1.39 | Fucosidase, alpha-L-1, tissue |
   LOC57146 | 1.38 | Promethin |
   RANBP2c | 1.36 | RAN binding protein 2 |
   HOXB7b,d | 1.36 | Homeobox B7 |
   PANX1c | 1.33 | Pannexin 1 |
   TGOLN2b | 1.31 | trans-Golgi network protein 2 |
   VWA1c | 1.29 | von Willebrand factor A domain containing 1 |