| ER+/PR+ | ER+/PR- | ER-/PR+ | ER-/PR- |  | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 | (n = 98,463) | (n = 19,886) | (n = 4,896) | (n = 31,930) |  | |||||||||||
Characteristics | No. at risk | No. deaths | HR | No. at risk | No. deaths | HR | 95% CI | No. at risk | No. deaths | HR | 95% CI | No. at risk | No. deaths | HR | 95% CI | p value for interaction |
All casesb | 98,463 | 7,319 | 1.0 | 19,886 | 2,434 | 1.4 | 1.3–1.5c | 4,896 | 848 | 1.8 | 1.6–1.9c | 31,930 | 6,300 | 2.3 | 2.2–2.4c |  |
Age at diagnosis, yearsd | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   <50 | 16,962 | 1,042 | 1.0 | 2,387 | 245 | 1.2 | 1.1–1.4c | 1,430 | 209 | 1.6 | 1.4–1.9c | 8,056 | 1,323 | 2.1 | 1.9–2.3c |  |
   50–64 | 23,467 | 1,104 | 1.0 | 4,745 | 416 | 1.5 | 1.3–1.7c | 1,072 | 124 | 1.5 | 1.2–1.8c | 7,651 | 1,214 | 2.3 | 2.1–2.5c |  |
   ≥65 | 25,078 | 1,496 | 1.0 | 5,563 | 540 | 1.5 | 1.3–1.7c | 718 | 119 | 2.1 | 1.8–2.6c | 5,536 | 1,020 | 2.6 | 2.4–2.8c | 0.03 |
Diagnosis yeare | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   1990–1992 | 8,298 | 1,285 | 1.0 | 1,889 | 419 | 1.3 | 1.2–1.5c | 597 | 146 | 1.6 | 1.3–1.9c | 2,850 | 831 | 1.7 | 1.5–1.9c |  |
   1993–1995 | 13,665 | 1,348 | 1.0 | 2,688 | 428 | 1.5 | 1.3–1.7c | 944 | 160 | 1.5 | 1.2–1.8c | 4,859 | 1,234 | 2.2 | 2.0–2.4c |  |
   1996–1998 | 19,350 | 837 | 1.0 | 3,493 | 282 | 1.5 | 1.3–1.7c | 971 | 121 | 2.1 | 1.7–2.6c | 6,181 | 1,059 | 2.8 | 2.5–3.1c |  |
   1999–2001 | 24,194 | 172 | 1.0 | 4,625 | 69 | 1.6 | 1.2–2.1c | 708 | 25 | 3.6 | 2.3–5.1c | 7,353 | 433 | 4.9 | 4.1–6.0c | <0.001 |
Race/Ethnicityf | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   Non-Hispanic white | 53,397 | 2,831 | 1.0 | 10,187 | 916 | 1.5 | 1.3–1.6c | 2,396 | 313 | 1.8 | 1.6–2.0c | 15,371 | 2,462 | 2.3 | 2.2–2.5c |  |
   African-American | 3,536 | 348 | 1.0 | 907 | 125 | 1.2 | 1.0–1.5c | 293 | 60 | 1.7 | 1.3–2.2c | 2,734 | 615 | 2.2 | 1.9–2.6c |  |
   Native American | 196 | 19 | 1.0 | 34 | 11 | 1.5 | 0.5–3.8 | 12 | 1 | 1.7 | 0.1–16.4 | 102 | 25 | 3.4 | 1.5–7.3c |  |
   Asian/Pacific Islander | 4,497 | 189 | 1.0 | 748 | 63 | 1.8 | 1.3–2.4c | 267 | 34 | 1.6 | 1.1–2.4c | 1,273 | 166 | 2.3 | 1.8–2.8c |  |
   Hispanic white | 3,881 | 255 | 1.0 | 819 | 83 | 1.3 | 1.0–1.7c | 252 | 44 | 1.9 | 1.3–2.6c | 1,763 | 289 | 2.3 | 1.9–2.8c | 0.77 |
Tumor stageg | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   I | 33,821 | 487 | 1.0 | 6,038 | 146 | 1.4 | 1.2–1.7c | 1,369 | 51 | 1.6 | 1.2–2.1c | 7,704 | 391 | 2.3 | 2.0–2.7c |  |
   II | 27,363 | 2,110 | 1.0 | 5,472 | 674 | 1.4 | 1.3–1.6c | 1,529 | 248 | 1.6 | 1.4–1.9c | 11,051 | 2,069 | 2.3 | 2.2–2.5c |  |
   III | 3,410 | 659 | 1.0 | 922 | 252 | 1.3 | 1.2–1.6c | 245 | 104 | 2.1 | 1.7–2.6c | 1,940 | 763 | 2.3 | 2.0–2.6c |  |
   IV | 672 | 302 | 1.0 | 192 | 102 | 1.3 | 1.0–1.6c | 59 | 42 | 1.9 | 1.3–2.7c | 357 | 245 | 2.3 | 1.9–2.8c | 0.45 |
Tumor size (cm)h | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   0–1.9 | 39,418 | 865 | 1.0 | 6,957 | 243 | 1.4 | 1.2–1.6c | 1,607 | 91 | 1.5 | 1.2–1.9c | 8,799 | 715 | 2.6 | 2.3–2.9c |  |
   2–5 | 22,579 | 2,081 | 1.0 | 4,781 | 708 | 1.5 | 1.3–1.6c | 1,331 | 253 | 1.8 | 1.5–2.0c | 10,214 | 2,019 | 2.2 | 2.1–2.4c |  |
   >5 | 2,718 | 526 | 1.0 | 761 | 206 | 1.3 | 1.1–1.6c | 217 | 89 | 2.2 | 1.7–2.7c | 1,730 | 636 | 2.2 | 1.9–2.5c | <0.001 |
Axillary lymph node statusi | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   Negative | 42,451 | 942 | 1.0 | 7,924 | 324 | 1.6 | 1.4–1.8c | 1,898 | 114 | 2.0 | 1.6–2.4c | 12,541 | 1,006 | 2.8 | 2.6–3.1c |  |
   1–3 | 14,953 | 1,021 | 1.0 | 2,828 | 324 | 1.5 | 1.3–1.7c | 790 | 133 | 1.8 | 1.5–2.1c | 4,857 | 977 | 2.5 | 2.3–2.7c |  |
   4–10 | 5,313 | 861 | 1.0 | 1,133 | 277 | 1.4 | 1.2–1.6c | 332 | 108 | 1.7 | 1.3–2.1c | 2,268 | 793 | 2.4 | 2.2–2.7c |  |
   ≥11 | 2,549 | 734 | 1.0 | 739 | 249 | 1.2 | 1.0–1.4c | 182 | 90 | 1.7 | 1.3–2.1c | 1,386 | 692 | 2.2 | 1.9–2.4c | 0.08 |
Tumor histologyj | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   Ductal | 52,178 | 2,919 | 1.0 | 9,978 | 994 | 1.5 | 1.4–1.6c | 2,711 | 390 | 1.8 | 1.6–2.0c | 18,542 | 3,040 | 2.3 | 2.2–2.5c |  |
   Lobular | 3,975 | 186 | 1.0 | 938 | 64 | 1.4 | 1.0–1.9c | 123 | 3 | 0.4 | 0.1–1.4 | 325 | 47 | 1.9 | 1.4–2.7c |  |
   Ductal/Lobular | 5,472 | 254 | 1.0 | 929 | 59 | 1.3 | 0.9–1.7 | 148 | 13 | 1.1 | 0.6–2.0 | 511 | 83 | 2.7 | 2.1–3.5c |  |
   Inflammatory | 241 | 52 | 1.0 | 77 | 22 | 1.4 | 0.8–2.3 | 39 | 19 | 3.4 | 1.9–6.1c | 258 | 123 | 3.5 | 2.4–5.0c |  |
   Comedo | 652 | 91 | 1.0 | 187 | 19 | 0.6 | 0.4–1.1 | 91 | 16 | 1.2 | 0.7–2.1 | 556 | 109 | 1.6 | 1.2–2.1c |  |
   Medullary | 120 | 14 | 1.0 | 73 | 6 | 0.7 | 0.2–2.2 | 48 | 4 | 0.9 | 0.2–3.0 | 716 | 54 | 0.7 | 0.4–1.4 | <0.001 |
Tumor gradek | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   1 | 13,854 | 156 | 1.0 | 2,141 | 40 | 1.6 | 1.1–2.3c | 310 | 6 | 1.0 | 0.4–2.5 | 661 | 32 | 2.6 | 1.7–3.9c |  |
   2 | 32,661 | 1,349 | 1.0 | 5,555 | 374 | 1.5 | 1.3–2.1c | 1,074 | 95 | 1.7 | 1.3–2.1c | 4,312 | 575 | 3.1 | 2.8–3.4c |  |
   3 | 17,352 | 1,873 | 1.0 | 4,613 | 710 | 1.3 | 1.2–1.5c | 1,694 | 319 | 1.7 | 1.5–1.9c | 14,967 | 2,635 | 2.1 | 1.9–2.2c |  |
   4 | 1,399 | 180 | 1.0 | 315 | 50 | 1.4 | 1.0–2.0c | 124 | 25 | 2.1 | 1.4–3.3c | 1,112 | 226 | 2.3 | 1.8–2.8c | <0.001 |