The protective role of pregnancy in breast cancer

Russo, Jose; Moral, Raquel; Balogh, Gabriela A; Mailo, Daniel; Russo, Irma H

doi:10.1186/bcr1029

Breast Cancer Research

Table 1 Genes attributed to the stem cells of the mammary gland (Stem cells 1)

From: The protective role of pregnancy in breast cancer

Gene	Abbreviation	Accession number	Cytoband	References
A disintegrin and metalloproteinase domain 12 (meltrin alpha)	ADAM12	NP_067673	10q26.3	[45]
Actin alpha 1, alpha smooth muscle antigen	ACTA1/ASMA	NP_001091	1q42.13-q42.2	[45]
Apolipoprotein E	APOE	NP_000032	19q13.2	[45]
ATP-binding cassette, subfamily A, member 1	ABCA1	NP_005493	9q31.1	[45]
ATP-binding cassette, subfamily G, member 2	ABCG2/BCRP	NP_004818	4q22	[42,43]
Catenin (cadherin-associated protein), alpha 1 (102 kDa)	CTNNA1	NP_001894	5q31	[39]
CD44 antigen	CD44	NP_001001392	11p13	[38]
Chemokine (C–C motif) ligand 2	CCL2	NP_002973	17q11.2-q21.1	[45]
Cyclin D₂	CCND2	NP_001750	12p13	[45]
Cyclin-dependent kinase inhibitor 1A (p21, Cip1)	CDKN1A	NP_510867	6p21.2	[49,50]
Decorin	DCN	NP_598014	12q13.2	[45]
Epithelial membrane protein 3	EMP3	NP_001416	19q13.3	[45]
Estrogen receptor 1	ESR1	NP_000116	6q25.1	[47, 49-51]
Fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)	FGFR1	NP_075599	8p11.2-p11.1	[45]
Flotillin 2 (epithelial-specific antigen)	FLOT2/ESA	NP_004466	17q11-q12	[36,37,44,51]
Four and a half LIM domains 1	FHL1	NP_001440	Xq26	[45]
Frizzled homolog 2 (Drosophila)	FZD2	NP_001457	17q21.1	[45]
FYN oncogene related to SRC, FGR, YES	FYN	NP_694593	6q21	[45]
Glycoprotein (transmembrane) nmb	GPNMB	NP_002501	7p15	[45]
Glypican 4	GPC4	NP_001439	Xq26.1	[45]
Growth-associated protein 43	GAP43	NP_002036	3q13.1-q13.2	[45]
Growth hormone receptor	GHR	NP_000154	5p13-p12	[45]
Insulin-like growth factor 2 receptor	IGF2R	NP_000867	6q26	[45]
Insulin-like growth factor binding protein 4	IGFBP4	NP_001543	17q12-q21.1	[45]
Insulin-like growth factor binding protein 7	IGFPP7	NP_001544	4q12	[45]
Integrin, alpha 6	ITGA6	NP_000201	2q31.1	[36,37,45]
Keratin 19	KRT19	NP_002267	17q21.2	[48-50]
Lymphocyte antige 6 complex, sca-1	LY6A/SCA-1	NP_034868	15	[40,41,43]
Membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10)	MME/CALLA/CD10	NP_009220	3q25.1-q25.2	[36,37,45,49,51]
Mucin 1 (transmembrane), epithelial membrane antigen	MUC1/EMA	NP_877418	1q21	[36,37, 43-45, 49,51]
Musashi homolog 1 (Drosophila)	MSI1	NP_002433	12q24.1-q24.31	[49,50]
Nidogen (enactin)	NID	NP_002499	1q43	[45]
Notch homolog 1, translocation-associated (Drosophila)	NOTCH1	NP_060087	9q34.3	[49]
Notch homolog 3 (Drosophila)	NOTCH3	NP_000426	19p13.2-p13.1	[45]
Notch homolog 4 (Drosophila)	NOTCH4	NP_004548	6p21.3	[49]
P53 target zinc finger protein	WIG1	NP_689426	3q26.3-q27	[45]
Periostin, osteoblast specific factor	POSTN	NP_006466	13q13.3	[45]
Platelet-derived growth factor receptor, beta polypeptide	PDGFRB	NP_002600	5q31-q32	[45]
Polycystic kidney disease 2 (autosomal dominant)	PKD2	NP_000288	4q21-q23	[45]
Progesterone receptor	PGR	NP_000917	11q22-q23	[41,47,49,50]
Prostate tumor overexpressed gene 1	PTOV1	NP_059128	19q13.33	[45]
Retinoic acid receptor responder (tazarotene induced) 3	RARRES3	NP_004576	11q23	[45]
Stem cell growth factor; lymphocyte secreted C-type lectin	SCGF	NP_002966	19q13.3	[45]
Telomerase reverse transcriptase	TERT	NP_937986	5p15.33	[43]
Tenascin C (hexabrachion)	TNC	NP_002151	9q33	[45]
Tight junction protein 1 (zona occludens 1)	TJP1	NP_783297	15q13	[39]
Tissue inhibitor of metalloproteinase 3	TIMP3	NP_000353	22q12.1-q13.2	[45]
Wiskott–Aldrich syndrome protein interacting protein	WASPIP	NP_003378	2q31.1	[45]

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