Polymorphism | Cases | Controls | OR* | 95% CI* | OR†| 95% CI†| ||
---|---|---|---|---|---|---|---|---|
 | N | % | N | % |  |  |  |  |
All subjects | Â | Â | Â | Â | Â | Â | Â | Â |
   Ile/Ile | 637 | 58.2 | 551 | 56.5 | 1 (Reference) | 1 (Reference) | ||
   Ile/Val or Val/Val | 457 | 41.8 | 425 | 43.5 | 0.92 | 0.76–1.10 | 0.90 | 0.75–1.09 |
Ile/Val | 396 | 36.2 | 356 | 36.5 | 0.96 | 0.79–1.16 | 0.97 | 0.79–1.18 |
Val/Val | 61 | 5.6 | 69 | 7.1 | 0.71 | 0.49–1.04 | 0.63 | 0.42–0.92 |
Localized disease‡ |  |  |  |  |  |  |  |  |
   Ile/Ile | 425 | 58.5 | 551 | 56.5 | 1 (Reference) | 1 (Reference) | ||
   Ile/Val or Val/Val | 301 | 41.5 | 425 | 43.5 | 0.91 | 0.74–1.12 | 0.90 | 0.73–1.12 |
Ile/Val | 257 | 35.4 | 356 | 36.5 | 0.94 | 0.76–1.16 | 0.95 | 0.76–1.19 |
Val/Val | 44 | 6.1 | 69 | 7.1 | 0.78 | 0.52–1.18 | 0.69 | 0.45–1.06 |
Regional or distant metastasis‡ |  |  |  |  |  |  |  |  |
   Ile/Ile | 195 | 57.5 | 551 | 56.5 | 1 (Reference) | 1 (Reference) | ||
   Ile/Val or Val/Val | 144 | 42.5 | 425 | 43.5 | 0.96 | 0.74–1.25 | 0.96 | 0.73–1.27 |
Ile/Val | 128 | 37.8 | 356 | 36.5 | 1.03 | 0.79–1.36 | 1.08 | 0.81–1.44 |
Val/Val | 16 | 4.7 | 69 | 7.1 | 0.60 | 0.34–1.09 | 0.49 | 0.26–0.90 |