The globalisation of breast cancer

Breast cancer is the commonest form of cancer in women worldwide; there were an estimated 1.4 million cases worldwide in 2008 [1] and there is no part of the world where breast cancer is now a rare form of cancer [2]. In all major regions of the world, breast cancer is the commonest, or second commonest, cancer in women [3]. 
 
Focus on breast cancer up until now has almost entirely been on the situation in high-income, westernized, industrialised countries. However, there is a world out there outwith North America and Western Europe where cancer is a major and growing problem facing public health. With the growth and ageing of the world's population, notable increases in life expectancy in people of lower-income levels in many countries and the increased tendency to adopt a westernised lifestyle, cancer is a rapidly growing global problem [4] and not one that the majority of the world is ready to cope with. 
 
Of course, in the above statements, 'cancer' could be replaced by 'vascular disease' or 'chronic obstructive pulmonary disease' or 'diabetes' or any number of chronic conditions associated with ageing populations adopting a westernised lifestyle. 
 
Today, there is no population around the world with a truly low risk of breast cancer and no woman in the world at a truly low risk of developing the disease. The global burden of breast cancer doubled between 1975 and 2000. It seems certain to double again between now and 2030 and the great majority of this burden will fall on low-income and lower middle-income countries, where the resources to deal with the current situation, never mind future increases, are absent to a great degree.

Breast cancer is the commonest form of cancer in women worldwide; there were an estimated 1.4 million cases world wide in 2008 [1] and there is no part of the world where breast cancer is now a rare form of cancer [2]. In all major regions of the world, breast cancer is the commonest, or second commonest, cancer in women [3].
Focus on breast cancer up until now has almost entirely been on the situation in high-income, westernized, industrialised countries. However, there is a world out there outwith North America and Western Europe where cancer is a major and growing problem facing public health. With the growth and ageing of the world's population, notable increases in life expectancy in people of lower-income levels in many countries and the increased tendency to adopt a westernised lifestyle, cancer is a rapidly growing global problem [4] and not one that the majority of the world is ready to cope with.
Of course, in the above statements, 'cancer' could be replaced by 'vascular disease' or 'chronic obstructive pulmo nary disease' or 'diabetes' or any number of chronic conditions associated with ageing populations adopting a westernised lifestyle.
Today, there is no population around the world with a truly low risk of breast cancer and no woman in the world at a truly low risk of developing the disease. Th e global burden of breast cancer doubled between 1975 and 2000. It seems certain to double again between now and 2030 and the great majority of this burden will fall on lowincome and lower middle-income countries, where the resources to deal with the current situation, never mind future increases, are absent to a great degree.

Breast cancer in Africa
Th e widespread belief that breast and other cancers are rare in low-income regions such as Africa is a myth. Akarolo-Anthony and colleagues [5] note that the probability that a woman who lives to age 65 in Kampala (Uga nda) would develop a cancer is only 20% lower than that of her European contemporary. What diff ers markedly is the probability that the African woman will live to be 65 years of age compared to women in developed countries. Th e concepts of risk and burden should be clearly diff erentiated and it should be noted that as life expectancy in Africa increases, so too will the cancer burden.
Akarolo-Anthony and colleagues [5] also note the increasing breast cancer rates occurring in Africa. Many factors could be associated with this increase but it appears attributable to a mixture of earlier age at menarche, women having fewer children and having their fi rst child at a later age, a reduction in the total time spent breast feeding, increased body mass index and a reduction in physical activity. Prospects for prevention through lifestyle alterations appear limited to increasing breast feeding, weight control and increasing levels of physical activity. Th ere are proven chemoprevention approaches [6] but these have not been widely adopted even in high-resource countries.
In these lower-income settings, the case fatality rate is poor in comparison to high-resource countries. Women with breast cancer either present with large, advanced tumours or do not present until the disease is at an incurable stage. Of course, women still die from breast cancer in such countries without ever coming into contact with medical services. Th e stigma associated with breast cancer in many countries is a major impediment to progress in controlling the disease and it should be a priority to reduce this stigma and eventually eliminate it entirely. Such stigma existed until recent decades even in countries such as the United States, but much work has been done to gradually overcome this phenomenon (see [7] for a clear description of this in the United States in the 1960s).
In lower-resource settings, treatment facilities, professional expertise and modern therapeutic technolo gies frequently do not exist. Howell [8] has summarised some of the diffi culties associated with introducing optimal treatment for breast cancer, as defi ned by standards in high-income countries, in the developing world, highlighted by the absence or low frequency of radiotherapy and systemic therapy services. In Africa, for example, a survey demonstrated that radiotherapy services were avail able in only 17 of 44 countries surveyed [9]. Th e Breast Health Global Initiative guidelines for the

© 2010 BioMed Central Ltd
The globalisation of breast cancer Peter Boyle* 1 and Antony Howell 2

S E C T I O N I N T R O D U C T I O N
*Correspondence: peter.boyle@i-pri.org 1 International Prevention Research Institute, 95 cours Lafayette, 69006 Lyon, France Full list of author information is available at the end of the article intro duction of radia tion therapy suggest the cheaper and simpler cobalt machines compared with linear accelerators or shorter schedules [10]. Not only are cobalt machines cheaper, but they are practical given the absence of reliable electricity supplies in many lower resource settings.
Modern, curative treatments and treatment facilities are not generally available, and pain control, palliative, supportive and terminal care are notoriously absent. Th ere are 29 countries identifi ed in Africa where the impor tation of opioid drugs is prohibited, and in many others the dosage administered varies 100-fold [11]. Merriman [12] describes the situation on the ground in Africa and presents a viable model for improving this situation in an eff ective and inexpensive manner.

Breast cancer in India
In India, there are remarkable diff erences between the incidence rates of breast cancer in metropolitan, urban and rural areas. Using age-standardised incidence rates for the years 2006 to 2008, the recent provisional report of the National Cancer Incidence Programme (NCRP, unpublished data) provides reliable information on cancer incidence in many parts of India. In the greater metropolitan areas of Mumbai and Chennai, the breast cancer incidence rates are 33 and 32.1 per 100,000, respectively; in the urban areas of Pune and Bhopal, the incidence rates are lower at 24.4 and 25.5 per 100,000, respectively; and in the rural areas of Barshi and Barshi Town the rates are lower still at 7.7 and 15.0 per 100,000, respectively.
Th e situation of breast cancer in India is, in a certain sense, fairly typical of the situation in many countries of Asia and other regions where dramatic economic and social change is taking place. Breast cancer is the second most common cancer among women in India and accounts for 7% of global burden of breast cancer and one-fi fth of all cancers among women in India. Over 90,000 new cancer cases are estimated to occur this year and over 50,000 women are estimated to die of it annually in India [1]. It is the number one cancer among women in urban areas of India. Th e incidence of breast cancer is approximately three times higher in urban areas compared to rural areas. Th e age-standardised incidence rates of breast cancer in India are still much lower than in high-resource countries (Figure 1). Given the myriad factors aff ecting the incidence of breast cancer, including the aging and growth of the Indian population and the increasing trends in breast cancer incidence, NS Murthy of the Indian Medical Research Council has estimated that the breast cancer burden in India will grow from 80,000 in 2005, through 122,000 new cases in 2011, and attain a level of 141,000 cases by 2016 (R Badwe, personal communication).
India, typical of many countries undergoing rapid economic evolution, and a special case in many respects because of the large size of its population, requires investment in prevention, diagnosis and treatment. Th ese include the widespread availability of reliable hormone receptor assessment, the availability of aff ordable drugs (for example, tamoxifen at US$1 per month and anthracyclines at US$25 per cycle), cost-eff ective early detection models and programmes, low-cost intervention to improve outcome in spite late presentation, and eff ective population prevention inter ventions, including increasing breast feeding, reducing overweight and obesity and increasing physical activity.

Conclusions: do it rather than talk about it
One of the major barriers to progress in low-income and lower middle-income countries was the failure to mention cancer and other chronic diseases in the Millennium Development Goals [4]. Signed and approved by most of the heads of state or government at the United Nations, these ten points were designed to help the 1 billion poorest people on the planet. Governments and health departments strive to accomplish these goals and one consequence is the lower priority currently aff orded to chronic disease in some of the world's poorest countries.
Th e growing epidemic of breast cancer in lower resource settings presents a major challenge to global public health, especially given the failure to cope with the current situation. Th is epidemic is here and now confronting the cancer control community and will assuredly become worse.
What can be done about this? Th e fi rst and crucial step must be to turn this question from the passive to the active voice. What can we do about this? Not your neighbour, not your cancer organisation or the cancer organisation in another country, nor some international association. Responsibility cannot be shifted onto the shoulders of others. Th e cancer control community needs to take more responsibility. Too often too diff use to be eff ective, this community needs to gain focus and acquire strong leadership. Th e time for committees, meetings, reports and declarations is over and the need for real and eff ective action is a call that must not be ignored.
Currently, a clearer picture of the global issues of cancer is emerging and clear priority targets can be identifi ed. Individually, we must get involved, and collectively, we can make a diff erence.
Th ere is an urgent need to enact eff ective cancer control policies in many parts of the world and the urgency is emphasised by the rapid changes taking place in cancer risk and cancer burden, particularly in lower and middle income countries. Breast [13] seeks to improve diagnosis, treatment and outcome through a highly successful, hands-on programme of scientifi c and clinical activities. Th e Susan G Komen Global Alliance, building on the great success of Susan G Komen for the Cure, is spearheading a coalition whose aim is to take active steps to reduce the breast cancer burden, and that of other cancers, among women living in poor regions of the world. Th e Alliance serves as a platform for innovative partnerships to provide screening and treatment to lowresource, under-served global populations and also as an organizing platform to bring together various organizations to design, fund and implement health programs that include screening and/or treatment for breast and cervical cancer.
Benjamin Disraeli and William Gladstone were two legendary British politicians and political rivals in the late 1800s. In Parliament, Disraeli was requested to diff erentiate a tragedy and a calamity. He responded that if Mr Gladstone was to fall in the Th ames, then that could be described as a tragedy. If someone was to pull him out, then that would be a calamity.
Th e impact of the current and future global cancer burden can be described as a tragedy. If we fail to do anything about this evolving epidemic, then that would be a calamity.