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Page 97 of 102

  1. We assessed the association between a glutamine repeat polymorphism in AIB1 and breast cancer risk in a case-control study (464 cases, 624 controls) nested within the Nurses' Health Study cohort. We observed no a...

    Authors: Christopher A Haiman, Susan E Hankinson, Donna Spiegelman, Graham A Colditz, Walter C Willett, Frank E Speizer, Myles Brown and David J Hunter
    Citation: Breast Cancer Research 2000 2:378
  2. Estrogen receptors are members of the nuclear receptor steroid family that exhibit specific structural features, ligand-binding domain sequence identity and dimeric interactions, that single them out. The crys...

    Authors: Marc Ruff, Monique Gangloff, Jean Marie Wurtz and Dino Moras
    Citation: Breast Cancer Research 2000 2:353
  3. Natural, synthetic and environmental estrogens have numerous effects on the development and physiology of mammals. Estrogen is primarily known for its role in the development and functioning of the female repr...

    Authors: Sylvia Curtis Hewitt, John F Couse and Kenneth S Korach
    Citation: Breast Cancer Research 2000 2:345
  4. Estrogens display intriguing tissue-selective action that is of great biomedical importance in the development of optimal therapeutics for the prevention and treatment of breast cancer, for menopausal hormone ...

    Authors: Benita S Katzenellenbogen and John A Katzenellenbogen
    Citation: Breast Cancer Research 2000 2:335
  5. Numerous models have been developed to address key elements in the biology of breast cancer development and progression. No model is ideal, but the most useful are those that reflect the natural history and hi...

    Authors: Gloria H Heppner, Fred R Miller and PV Malathy Shekhar
    Citation: Breast Cancer Research 2000 2:331
  6. The fibroblast growth factor receptor (FGFR)2 gene has been shown to be amplified in 5-10% of breast cancer patients. A breast cancer cell line developed in our laboratory, SUM-52PE, was shown to have a 12-fol...

    Authors: Stacey L Tannheimer, Alnawaz Rehemtulla and Stephen P Ethier
    Citation: Breast Cancer Research 2000 2:311
  7. Protein truncation test (PTT) and single-strand conformation polymorphism (SSCP) assay were used to scan the BRCA1 and BRCA2 genes in 136 unrelated Italian breast/ovarian cancer patients. In the sample tested, BR...

    Authors: Laura Ottini, Cristina D'Amico, Cristiana Noviello, Salvatore Lauro, Maurizio Lalle, Giuseppe Fornarini, Orsola Anna Colantuoni, Claudia Pizzi, Enrico Cortesi, Sandro Carlini, Fiorella Guadagni, Angelo Raffaele Bianco, Luigi Frati, Alma Contegiacomo and Renato Mariani-Costantini
    Citation: Breast Cancer Research 2000 2:307
  8. Mammography is an effective screening modality for the early detection of breast cancer. The reduction in breast cancer mortality is greater for women aged over 50 at screening than for women aged under 50. Ma...

    Authors: Nick Day and Ruth Warren
    Citation: Breast Cancer Research 2000 2:247
  9. The acetyltransferase p300 was first identified associated with the adenoviral transforming protein E1A, suggesting a potential role for p300 in the regulation of cell proliferation. Direct evidence demonstrat...

    Authors: Andrew C Phillips and Karen H Vousden
    Citation: Breast Cancer Research 2000 2:244
  10. New guidelines for the collection and use of human tissues for research will impose new requirements on researchers to seek ethical approval and patient consent. This extends to the use of surplus tissue, such...

    Authors: Mitch Dowsett
    Citation: Breast Cancer Research 2000 2:241
  11. The use of human tissue, and material derived from such tissue, for research purposes is currently the subject of much debate. This debate needs to address several issues, including: the principle of abandonme...

    Authors: Wendy Prime, Mark E Sobel and C Simon Herrington
    Citation: Breast Cancer Research 2000 2:237
  12. We describe here the expression pattern of the breast cell growthinhibitor Mammastatin in normal and breast cancer cells. Normal Cells (NHMC)over-express Mammastatin in low calcium media. Mammastatin has been ...

    Authors: Paul R Ervin Jr, Rebecca L Johnston, Milena Cankovic, David McDonagh and Neil Chi
    Citation: Breast Cancer Research 2000 2:E009
  13. This paper describes the derivation and characterization of a novel, conditionally immortal mammary epithelial cell line named KIM-2. These cells were derived from mid-pregnant mammary glands of a mouse harbou...

    Authors: Katrina E Gordon, Bert Binas, Rachel S Chapman, Kathreena M Kurian, Richard W E Clarkson, A John Clark, E Birgitte Lane and Christine J Watson
    Citation: Breast Cancer Research 2000 2:222
  14. The ability of growth factors and their cognate receptors to induce mammary epithelial proliferation and differentiation is dependent on their ability to activate a number of specific signal transduction pathw...

    Authors: Eran R Andrechek and William J Muller
    Citation: Breast Cancer Research 2000 2:211
  15. Both the non-receptor tyrosine kinase, c-Src, and members of the epidermal growth factor (EGF) receptor family are overexpressed in high percentages of human breast cancers. Because these molecules are plasma ...

    Authors: Jacqueline S Biscardi, Rumey C Ishizawar, Corinne M Silva and Sarah J Parsons
    Citation: Breast Cancer Research 2000 2:203
  16. The past decade has seen the definition of key signalling pathways downstream of receptor tyrosine kinases (RTKs) in terms of their components and the protein-protein interactions that facilitate signal transd...

    Authors: Rania Kairouz and Roger J Daly
    Citation: Breast Cancer Research 2000 2:197
  17. The fibroblast growth factors [Fgfs (murine), FGFs (human)] constitute a large family of ligands that signal through a class of cell-surface tyrosine kinase receptors. Fgf signalling has been associated in vitro ...

    Authors: Clive Dickson, Bradley Spencer-Dene, Christian Dillon and Vera Fantl
    Citation: Breast Cancer Research 2000 2:191
  18. Cross-communication between different signalling systems is critical for the integration of multiple and changing environmental influences on individual cells. The epidermal growth factor receptor (EGFR) has b...

    Authors: Norbert Prenzel, Esther Zwick, Michael Leserer and Axel Ullrich
    Citation: Breast Cancer Research 2000 2:184
  19. Cells are continuously exposed to diverse stimuli ranging from soluble endocrine and paracrine factors to signalling molecules on neighbouring cells. Receptors of the tyrosine kinase family play an important r...

    Authors: Nancy E Hynes
    Citation: Breast Cancer Research 2000 2:154
  20. The mammary epithelium undergoes cyclical periods of cellular proliferation, differentiation and regression. These processes are under the control of the hormones secreted during pregnancy, lactation and invol...

    Authors: Bernd Groner and Lothar Hennighausen
    Citation: Breast Cancer Research 2000 2:149
  21. We previously reported that ductal infiltrating carcinomas (DIC) of the human breast display profound modifications of the stromal architecture, associated with anomalous collagen composition. The major altera...

    Authors: Ida Pucci-Minafra, Cintia Carella, Rosalia Cirincione, Silvana Chimenti, Salvatore Minafra and Claudio Luparello
    Citation: Breast Cancer Research 2000 2:E008
  22. We tested the hypothesis that BRCA1 may play a role in the regulation of ovarian tumor cell death as well as the inhibition of ovarian cell proliferation. Introduction of BRCA1 antisense retroviral constructs ...

    Authors: Lois A Annab, Rebecca Hawkins, Greg Solomon, J Carl Barrett and Cynthia A Afshari
    Citation: Breast Cancer Research 2000 2:139
  23. Altered responsiveness to extracellular signals and cell cycle dysregulation are hallmarks of cancer. The cell cycle is governed by cyclin-dependent kinases (cdks) that integrate mitogenic and growth inhibitor...

    Authors: Jeffrey Donovan and Joyce Slingerland
    Citation: Breast Cancer Research 2000 2:116

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