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  1. Despite the critical importance of ovarian steroids in the treatment of breast cancer, little is known about the acquisition or loss of estrogen and progesterone responsiveness in either the normal or neoplast...

    Authors: Sandra Z Haslam and Terry L Woodward
    Citation: Breast Cancer Research 2001 3:365
  2. The PTEN gene is often mutated in primary human tumors and cell lines, but the low rate of somatic PTEN mutation in human breast cancer has led to debate over the role of this tumor suppressor in this disease. Th...

    Authors: Teresa Petrocelli and Joyce M Slingerland
    Citation: Breast Cancer Research 2001 3:356
  3. Since the original identification of Wnt1 as a mammary oncogene in mouse mammary tumor virus infected mice, questions have been asked about its relevance to human breast cancer. Wnt1 is now known to be one of a l...

    Authors: Anthony MC Brown
    Citation: Breast Cancer Research 2001 3:351
  4. The mammary gland undergoes apoptosis when estrogen ablation occurs, either naturally or enforced. The gland is known to execute the apoptotic process post weaning. Although the involuting mammary gland displa...

    Authors: Reginald Halaby
    Citation: Breast Cancer Research 2001 1:4
  5. The accumulation of mutations is a feature of all normal cells. The probability of any individual gene in any cell acquiring a mutation is, however, low. Cancer is therefore a rare disease in comparison with t...

    Authors: Ian PM Tomlinson
    Citation: Breast Cancer Research 2001 3:299
  6. Reactive oxygen species (ROS) damage DNA, but the role of ROS in breast carcinoma may not be limited to the mutagenic activity that drives carcinoma initiation and progression. Carcinoma cells in vitro and in viv...

    Authors: Nicholas S Brown and Roy Bicknell
    Citation: Breast Cancer Research 2001 3:323
  7. Two recent papers provide new evidence relevant to the role of the breast cancer susceptibility gene BRCA2 in DNA repair. Moynahan et al provide genetic data indicating a requirement for BRCA2 in homology-depende...

    Authors: Brian J Orelli and Douglas K Bishop
    Citation: Breast Cancer Research 2001 3:294
  8. Approximately half of breast cancer patients with stage I–III disease will suffer metastatic disease despite resection with tumour-free margins. In 30–40% of these patients, individual carcinoma cells can alre...

    Authors: Stephan Braun and Nadia Harbeck
    Citation: Breast Cancer Research 2001 3:285

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