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  1. Tumour hypoxia is a driver of breast cancer progression associated with worse prognosis and more aggressive disease. The cellular response to hypoxia is mediated by the hypoxia-inducible transcription factors ...

    Authors: Edward J. Jarman, Carol Ward, Arran K. Turnbull, Carlos Martinez-Perez, James Meehan, Chrysi Xintaropoulou, Andrew H. Sims and Simon P. Langdon

    Citation: Breast Cancer Research 2019 21:10

    Content type: Research article

    Published on:

  2. Immunochemotherapy, the combined use of immunotherapy and chemotherapy, has demonstrated great promise in several cancers. LTX-315 is an oncolytic peptide with potent immunomodulatory properties designed for t...

    Authors: Ketil A. Camilio, Meng-Yu Wang, Brynjar Mauseth, Stein Waagene, Gunnar Kvalheim, Øystein Rekdal, Baldur Sveinbjørnsson and Gunhild M. Mælandsmo

    Citation: Breast Cancer Research 2019 21:9

    Content type: Research article

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  3. High mammographic density is associated with breast cancer and with delayed detection. We have examined whether localized density, at the site of the subsequent cancer, is independently associated with being d...

    Authors: Fredrik Strand, Edward Azavedo, Roxanna Hellgren, Keith Humphreys, Mikael Eriksson, John Shepherd, Per Hall and Kamila Czene

    Citation: Breast Cancer Research 2019 21:8

    Content type: Research article

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  4. Clinical studies suggest that obesity, in addition to promoting breast cancer aggressiveness, is associated with a decrease in chemotherapy efficacy, although the mechanisms involved remain elusive. As chemoth...

    Authors: Camille Lehuédé, Xia Li, Stéphanie Dauvillier, Charlotte Vaysse, Camille Franchet, Emily Clement, David Esteve, Mélanie Longué, Léonor Chaltiel, Sophie Le Gonidec, Ikrame Lazar, Aline Geneste, Charles Dumontet, Philippe Valet, Laurence Nieto, Frédérique Fallone…

    Citation: Breast Cancer Research 2019 21:7

    Content type: Research article

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  5. Epithelial-mesenchymal transition (EMT) occurs in the tumor microenvironment and presents an important mechanism of tumor cell intravasation, stemness acquisition, and metastasis. During metastasis, tumor cell...

    Authors: Hye Yeon Choi, Gwang-Mo Yang, Ahmed Abdal Dayem, Subbroto Kumar Saha, Kyeongseok Kim, Youngbum Yoo, Kwonho Hong, Jin-Hoi Kim, Cassian Yee, Kyung-Mi Lee and Ssang-Goo Cho

    Citation: Breast Cancer Research 2019 21:6

    Content type: Research article

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  6. Many human breast cancers overexpress the E3 ubiquitin ligase MDM2 and its homolog MDMX. Expression of MDM2 and MDMX occurs in estrogen receptor α-positive (ERα+) breast cancer and triple-negative breast cancer (...

    Authors: Chong Gao, Gu Xiao, Alessandra Piersigilli, Jiangtao Gou, Olorunseun Ogunwobi and Jill Bargonetti

    Citation: Breast Cancer Research 2019 21:5

    Content type: Research article

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  7. Dissemination of breast cancers to the brain is associated with poor patient outcome and limited therapeutic options. In this study we sought to identify novel regulators of brain metastasis by profiling mouse...

    Authors: Magdalena Kijewska, Carmen Viski, Frances Turrell, Amanda Fitzpatrick, Antoinette van Weverwijk, Qiong Gao, Marjan Iravani and Clare M. Isacke

    Citation: Breast Cancer Research 2019 21:4

    Content type: Research article

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  8. Breast cancer is a partially heritable trait and genome-wide association studies (GWAS) have identified over 180 common genetic variants associated with breast cancer. We have previously performed breast cance...

    Authors: Joshua Hoffman, Laura Fejerman, Donglei Hu, Scott Huntsman, Min Li, Esther M. John, Gabriela Torres-Mejia, Larry Kushi, Yuan Chun Ding, Jeffrey Weitzel, Susan L. Neuhausen, Paul Lott, Magdalena Echeverry, Luis Carvajal-Carmona, Esteban Burchard, Celeste Eng…

    Citation: Breast Cancer Research 2019 21:3

    Content type: Research article

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  9. The risk of recurrence for endocrine-treated breast cancer patients persists for many years or even decades following surgery and apparently successful adjuvant therapy. This period of dormancy and acquired re...

    Authors: Cigdem Selli, Arran K. Turnbull, Dominic A. Pearce, Ang Li, Anu Fernando, Jimi Wills, Lorna Renshaw, Jeremy S. Thomas, J. Michael Dixon and Andrew H. Sims

    Citation: Breast Cancer Research 2019 21:2

    Content type: Research article

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  10. To obtain a deep understanding of the mechanism by which breast cancer develops, the genes involved in tumorigenesis should be analyzed in vivo. Mouse mammary gland can regenerate completely from a mammary ste...

    Authors: Hiroaki Tagaya, Kosuke Ishikawa, Yoshito Hosokawa, Shun Kobayashi, Yukino Ueoka, Mayuna Shimada, Yasuko Ohashi, Hirofumi Mikami, Mizuki Yamamoto, Tatsuya Ihara, Kentaro Kumazawa, Kosuke Sugihara, Naoki Goshima, Shinya Watanabe and Kentaro Semba

    Citation: Breast Cancer Research 2019 21:1

    Content type: Research article

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  11. Fully automated assessment of mammographic density (MD), a biomarker of breast cancer risk, is being increasingly performed in screening settings. However, data on body mass index (BMI), a confounder of the MD...

    Authors: Sue Hudson, Kirsti Vik Hjerkind, Sarah Vinnicombe, Steve Allen, Cassia Trewin, Giske Ursin, Isabel dos-Santos-Silva and Bianca L. De Stavola

    Citation: Breast Cancer Research 2018 20:156

    Content type: Research article

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  12. There is a growing interest in delivering more personalised, risk-based breast cancer screening protocols. This requires population-level validation of practical models that can stratify women into breast canc...

    Authors: Carolyn Nickson, Pietro Procopio, Louiza S. Velentzis, Sarah Carr, Lisa Devereux, Gregory Bruce Mann, Paul James, Grant Lee, Cameron Wellard and Ian Campbell

    Citation: Breast Cancer Research 2018 20:155

    Content type: Research article

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  13. The role of tumor-associated macrophages (TAMs) in the cancer immune landscape and their potential as treatment targets or modulators of response to treatment are gaining increasing interest. TAMs display high...

    Authors: Vasiliki Pelekanou, Franz Villarroel-Espindola, Kurt A. Schalper, Lajos Pusztai and David L. Rimm

    Citation: Breast Cancer Research 2018 20:154

    Content type: Research article

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    The Letter to this article has been published in Breast Cancer Research 2019 21:49

  14. Overdiagnosis, defined as the detection of a cancer that would not become clinically apparent in a woman’s lifetime without screening, has become a growing concern. Similar underlying risk of breast cancer in ...

    Authors: Wendy Yi-Ying Wu, Sven Törnberg, Klara Miriam Elfström, Xijia Liu, Lennarth Nyström and Håkan Jonsson

    Citation: Breast Cancer Research 2018 20:153

    Content type: Research article

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  15. Case–control studies show that mammographic density is a better risk factor when defined at higher than conventional pixel-brightness thresholds. We asked if this applied to interval and/or screen-detected can...

    Authors: Tuong L. Nguyen, Ye K. Aung, Shuai Li, Nhut Ho Trinh, Christopher F. Evans, Laura Baglietto, Kavitha Krishnan, Gillian S. Dite, Jennifer Stone, Dallas R. English, Yun-Mi Song, Joohon Sung, Mark A. Jenkins, Melissa C. Southey, Graham G. Giles and John L. Hopper

    Citation: Breast Cancer Research 2018 20:152

    Content type: Research article

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  16. The ability of solid tumor cells to resist anoikis, apoptosis triggered by cell detachment from the extracellular matrix (ECM), is thought to be critical for 3D tumor growth. ErbB2/Her2 oncoprotein is often ov...

    Authors: Iman Aftab Khan, Byong Hoon Yoo, Michael McPhee, Olivier Masson, Alexi Surette, Kelly Dakin-Hache, Tallal Younis, Gillian Bethune and Kirill V. Rosen

    Citation: Breast Cancer Research 2018 20:151

    Content type: Research article

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  17. Prevention of triple-negative breast cancer (TNBC) is hampered by lack of knowledge about the drivers of tumorigenesis.

    Authors: Anjana Bhardwaj, Harpreet Singh, Celestine Marie Trinidad, Constance T. Albarracin, Kelly K. Hunt and Isabelle Bedrosian

    Citation: Breast Cancer Research 2018 20:150

    Content type: Research article

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  18. Tamoxifen treatment greatly reduces a woman’s risk of developing a second primary breast cancer. There is, however, substantial variability in treatment response, some of which may be attributed to germline ge...

    Authors: Jennifer D. Brooks, Elizabeth A. Comen, Anne S. Reiner, Irene Orlow, Siok F. Leong, Xiaolin Liang, Lene Mellemkjær, Julia A. Knight, Charles F. Lynch, Esther M. John, Leslie Bernstein, Meghan Woods, David R. Doody, Kathleen E. Malone and Jonine L. Bernstein

    Citation: Breast Cancer Research 2018 20:149

    Content type: Research article

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  19. The early detection of metastasis based on biomarkers in plasma may improve cancer prognosis and guide treatment. The aim of this work was to characterize alterations in metabolites of the arginine pathway, en...

    Authors: Kamil Kus, Agnieszka Kij, Agnieszka Zakrzewska, Agnieszka Jasztal, Marta Stojak, Maria Walczak and Stefan Chlopicki

    Citation: Breast Cancer Research 2018 20:148

    Content type: Research article

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  20. Few published breast cancer (BC) risk prediction models consider the heterogeneity of predictor variables between estrogen-receptor positive (ER+) and negative (ER-) tumors. Using data from two large cohorts, ...

    Authors: Kuanrong Li, Garnet Anderson, Vivian Viallon, Patrick Arveux, Marina Kvaskoff, Agnès Fournier, Vittorio Krogh, Rosario Tumino, Maria-Jose Sánchez, Eva Ardanaz, María-Dolores Chirlaque, Antonio Agudo, David C. Muller, Todd Smith, Ioanna Tzoulaki, Timothy J. Key…

    Citation: Breast Cancer Research 2018 20:147

    Content type: Research article

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  21. The pathophysiology of chemotherapy-induced peripheral neuropathy (CIPN) is not well understood. Currently, dose reduction is the only recommendation for alleviating symptoms, often leading to premature treatm...

    Authors: Jennifer M. Mongiovi, Gary R. Zirpoli, Rikki Cannioto, Lara E. Sucheston-Campbell, Dawn L. Hershman, Joseph M. Unger, Halle C. F. Moore, James A. Stewart, Claudine Isaacs, Timothy J. Hobday, Muhammad Salim, Gabriel N. Hortobagyi, Julie R. Gralow, G. Thomas Budd, Kathy S. Albain, Christine B. Ambrosone…

    Citation: Breast Cancer Research 2018 20:146

    Content type: Research article

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  22. A combination of entinostat, all-trans retinoic acid, and doxorubicin (EAD) induces cell death and differentiation and causes significant regression of xenografts of triple-negative breast cancer (TNBC).

    Authors: Vanessa F. Merino, Soonweng Cho, Nguyen Nguyen, Helen Sadik, Athira Narayan, Conover Talbot Jr, Leslie Cope, Xian C. Zhou, Zhe Zhang, Balázs Győrffy and Saraswati Sukumar

    Citation: Breast Cancer Research 2018 20:145

    Content type: Research article

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  23. Epidemiologic studies have, variably, shown the concomitant use of statin drugs to be beneficial to cancer outcomes. Statin drugs have been FDA approved for three decades for the treatment of high cholesterol ...

    Authors: Colin H. Beckwitt, Adam Brufsky, Zoltán N. Oltvai and Alan Wells

    Citation: Breast Cancer Research 2018 20:144

    Content type: Review

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  24. Lymph node (LN) metastasis is an important prognostic parameter in breast carcinoma, a crucial site for tumour–immune cell interaction and a gateway for further dissemination of tumour cells to other metastati...

    Authors: Gaurav Chatterjee, Trupti Pai, Thomas Hardiman, Kelly Avery-Kiejda, Rodney J. Scott, Jo Spencer, Sarah E. Pinder and Anita Grigoriadis

    Citation: Breast Cancer Research 2018 20:143

    Content type: Review

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  25. Results from previous studies indicate that use of low-dose aspirin may improve breast cancer prognosis. We evaluated aspirin use and breast cancer outcomes in relation to clinical characteristics as well as d...

    Authors: Gabriella Frisk, Sara Ekberg, Elisabet Lidbrink, Sandra Eloranta, Malin Sund, Irma Fredriksson, Mats Lambe and Karin E. Smedby

    Citation: Breast Cancer Research 2018 20:142

    Content type: Research article

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  26. The presence of circulating tumor cells (CTCs) in patients with breast cancer correlates to a bad prognosis. Yet, CTCs are detectable in only a minority of patients with progressive breast cancer, and factors ...

    Authors: Marcus Vetter, Julia Landin, Barbara Maria Szczerba, Francesc Castro-Giner, Sofia Gkountela, Cinzia Donato, Ilona Krol, Ramona Scherrer, Catharina Balmelli, Alexandra Malinovska, Alfred Zippelius, Christian Kurzeder, Viola Heinzelmann-Schwarz, Walter Paul Weber, Christoph Rochlitz and Nicola Aceto

    Citation: Breast Cancer Research 2018 20:141

    Content type: Research article

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  27. Junctional adhesion molecule-A (JAM-A) is an adhesion molecule whose overexpression on breast tumor tissue has been associated with aggressive cancer phenotypes, including human epidermal growth factor recepto...

    Authors: Astrid O. Leech, Sri HariKrishna Vellanki, Emily J. Rutherford, Aoife Keogh, Hanne Jahns, Lance Hudson, Norma O’Donovan, Siham Sabri, Bassam Abdulkarim, Katherine M. Sheehan, Elaine W. Kay, Leonie S. Young, Arnold D. K. Hill, Yvonne E. Smith and Ann M. Hopkins

    Citation: Breast Cancer Research 2018 20:140

    Content type: Research article

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  28. The sensitivity of estrogen receptor-positive breast cancers to tamoxifen treatment varies considerably, and the molecular mechanisms affecting the response rates are manifold. The human epidermal growth facto...

    Authors: Anja Kathrin Wege, Dominik Chittka, Stefan Buchholz, Monika Klinkhammer-Schalke, Simone Diermeier-Daucher, Florian Zeman, Olaf Ortmann and Gero Brockhoff

    Citation: Breast Cancer Research 2018 20:139

    Content type: Research article

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  29. Early analyses of human breast cancer identified high expression of the insulin-like growth factor type 1 receptor (IGF-1R) correlated with hormone receptor positive breast cancer and associated with a favorab...

    Authors: Alison E. Obr, Sushil Kumar, Yun-Juan Chang, Joseph J. Bulatowicz, Betsy J. Barnes, Raymond B. Birge, Deborah A. Lazzarino, Emily Gallagher, Derek LeRoith and Teresa L. Wood

    Citation: Breast Cancer Research 2018 20:138

    Content type: Research article

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  30. Cancer progression is influenced by genetic aberrations in the cancer cell population as well as by other factors including the microenvironment present within a tumour. Direct interactions between various cel...

    Authors: Sara Rhost, Éamon Hughes, Hannah Harrison, Svanheidur Rafnsdottir, Hanna Jacobsson, Pernilla Gregersson, Ylva Magnusson, Paul Fitzpatrick, Daniel Andersson, Karoline Berger, Anders Ståhlberg and Göran Landberg

    Citation: Breast Cancer Research 2018 20:137

    Content type: Research article

    Published on:

  31. Following publication of the original article [1], the authors reported a typesetting error in the spelling of the second author’s name.

    Authors: John A. Reid, Peter A. Mollica, Robert D. Bruno and Patrick C. Sachs

    Citation: Breast Cancer Research 2018 20:136

    Content type: Correction

    Published on:

    The original article was published in Breast Cancer Research 2018 20:122

  32. Inflammation is an important candidate mechanism underlying cancer and cancer treatment-related cognitive impairment. We investigated levels of blood cell–based inflammatory markers in breast cancer survivors ...

    Authors: Kimberly D. van der Willik, Vincent Koppelmans, Michael Hauptmann, Annette Compter, M. Arfan Ikram and Sanne B. Schagen

    Citation: Breast Cancer Research 2018 20:135

    Content type: Research article

    Published on:

  33. Osteoporosis, an indicator of significant bone loss, has been consistently reported among older breast cancer survivors. Data are limited on the incidence of osteopenia, an earlier indicator of bone loss, and ...

    Authors: Cody Ramin, Betty J. May, Richard B. S. Roden, Mikiaila M. Orellana, Brenna C. Hogan, Michelle S. McCullough, Dana Petry, Deborah K. Armstrong and Kala Visvanathan

    Citation: Breast Cancer Research 2018 20:134

    Content type: Research article

    Published on:

  34. We have previously shown that galactosylceramide (GalCer) affects the tumourigenic and metastatic properties of breast cancer cells by acting as an anti-apoptotic molecule. Since GalCer is a precursor molecule...

    Authors: Jaroslaw Suchanski, Jedrzej Grzegrzolka, Tomasz Owczarek, Pawel Pasikowski, Aleksandra Piotrowska, Bartlomiej Kocbach, Aleksandra Nowak, Piotr Dziegiel, Andrzej Wojnar and Maciej Ugorski

    Citation: Breast Cancer Research 2018 20:133

    Content type: Research article

    Published on:

  35. The association between body mass index (BMI) and risk of breast cancer depends on time of life, but it is unknown whether this association depends on a woman’s familial risk.

    Authors: John L. Hopper, Gillian S. Dite, Robert J. MacInnis, Yuyan Liao, Nur Zeinomar, Julia A. Knight, Melissa C. Southey, Roger L. Milne, Wendy K. Chung, Graham G. Giles, Jeanine M. Genkinger, Sue-Anne McLachlan, Michael L. Friedlander, Antonis C. Antoniou, Prue C. Weideman, Gord Glendon…

    Citation: Breast Cancer Research 2018 20:132

    Content type: Research article

    Published on:

  36. Amphiregulin (AREG), a ligand of the epidermal growth factor receptor, is not only essential for proper mammary ductal development, but also associated with breast cancer proliferation and growth. In the absen...

    Authors: Serena P. H. Mao, Minji Park, Ramon M. Cabrera, John R. Christin, George S. Karagiannis, Maja H. Oktay, Dietmar M. W. Zaiss, Scott I. Abrams, Wenjun Guo, John S. Condeelis, Paraic A. Kenny and Jeffrey E. Segall

    Citation: Breast Cancer Research 2018 20:131

    Content type: Research article

    Published on:

  37. De novo or acquired resistance in breast cancer leads to treatment failures and disease progression. In human epidermal growth factor receptor 2 (HER2)-positive (HER2+) breast cancer, Src, a non-receptor tyros...

    Authors: Brooke N. McKnight and Nerissa T. Viola-Villegas

    Citation: Breast Cancer Research 2018 20:130

    Content type: Research article

    Published on:

  38. Stem cells are precursors for all mammary epithelia, including ductal and alveolar epithelia, and myoepithelial cells. In vivo mammary epithelia reside in a tissue context and interact with their milieu via re...

    Authors: Safiah Olabi, Ahmet Ucar, Keith Brennan and Charles H. Streuli

    Citation: Breast Cancer Research 2018 20:128

    Content type: Research article

    Published on:

  39. Bone is one of the most frequent metastatic sites of advanced breast cancer. Current therapeutic agents aim to inhibit osteoclast-mediated bone resorption but only have palliative effects. During normal bone r...

    Authors: Xuxiang Liu, Minghui Cao, Melanie Palomares, Xiwei Wu, Arthur Li, Wei Yan, Miranda Y. Fong, Wing-Chung Chan and Shizhen Emily Wang

    Citation: Breast Cancer Research 2018 20:127

    Content type: Research article

    Published on:

  40. Although metastasis is ultimately responsible for about 90% of breast cancer mortality, the vast majority of breast-cancer-related deaths are due to progressive recurrences from non-metastatic disease. Current...

    Authors: Sruthi Ravindranathan, Khue G. Nguyen, Samantha L. Kurtz, Haven N. Frazier, Sean G. Smith, Bhanu prasanth Koppolu, Narasimhan Rajaram and David A. Zaharoff

    Citation: Breast Cancer Research 2018 20:126

    Content type: Research article

    Published on:

  41. Circadian rhythms maintain tissue homeostasis during the 24-h day-night cycle. Cell-autonomous circadian clocks play fundamental roles in cell division, DNA damage responses and metabolism. Circadian disruptio...

    Authors: Eleanor Broadberry, James McConnell, Jack Williams, Nan Yang, Egor Zindy, Angela Leek, Rachel Waddington, Leena Joseph, Miles Howe, Qing-Jun Meng and Charles H Streuli

    Citation: Breast Cancer Research 2018 20:125

    Content type: Research article

    Published on:

  42. Exercise is an effective strategy to improve quality of life and physical fitness in breast cancer survivors; however, few studies have focused on the early survivorship period, minorities, physically inactive...

    Authors: Christina M Dieli-Conwright, Kerry S Courneya, Wendy Demark-Wahnefried, Nathalie Sami, Kyuwan Lee, Frank C Sweeney, Christina Stewart, Thomas A Buchanan, Darcy Spicer, Debu Tripathy, Leslie Bernstein and Joanne E Mortimer

    Citation: Breast Cancer Research 2018 20:124

    Content type: Research article

    Published on:

  43. Endocrine therapy is recommended for patients with hormone receptor-positive (HR+) advanced and metastatic breast cancer without visceral crisis (symptomatic visceral disease). However, many patients experience d...

    Authors: Gabriel N. Hortobagyi

    Citation: Breast Cancer Research 2018 20:123

    Content type: Review

    Published on:

  44. The presence of disseminated tumor cells (DTCs) in bone marrow (BM) is an independent prognostic factor in early breast cancer but does not uniformly predict outcome. Tumor cells can persist in a quiescent sta...

    Authors: Elin Borgen, Maria C. Rypdal, Maria Soledad Sosa, Anne Renolen, Ellen Schlichting, Per E. Lønning, Marit Synnestvedt, Julio A. Aguirre-Ghiso and Bjørn Naume

    Citation: Breast Cancer Research 2018 20:120

    Content type: Short report

    Published on:

  45. Standard three-dimensional (3D) in vitro culture techniques, such as those used for mammary epithelial cells, rely on random distribution of cells within hydrogels. Although these systems offer advantages over tr...

    Authors: John A. Reid, Peter A. Mollica, Robert D. Bruno and Patrick C. Sachs

    Citation: Breast Cancer Research 2018 20:122

    Content type: Research article

    Published on:

    The Correction to this article has been published in Breast Cancer Research 2018 20:136

  46. Exposure to road traffic noise was associated with increased risk of estrogen receptor (ER)-negative (ER-) breast cancer in a previous cohort study, but not with overall or ER-positive (ER+) breast cancer, or ...

    Authors: Zorana Jovanovic Andersen, Jeanette Therming Jørgensen, Lea Elsborg, Søren Nymand Lophaven, Claus Backalarz, Jens Elgaard Laursen, Torben Holm Pedersen, Mette Kildevæld Simonsen, Elvira Vaclavik Bräuner and Elsebeth Lynge

    Citation: Breast Cancer Research 2018 20:119

    Content type: Research article

    Published on:

  47. Previous studies on the role of TP53 mutation in breast cancer treatment response and survival are contradictory and inconclusive, limited by the use of different endpoints to determine clinical significance and ...

    Authors: Nathan A. Ungerleider, Sonia G. Rao, Ashkan Shahbandi, Douglas Yee, Tianhua Niu, Wesley D. Frey and James G. Jackson

    Citation: Breast Cancer Research 2018 20:115

    Content type: Research article

    Published on:

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