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  1. We assessed the association between a glutamine repeat polymorphism in AIB1 and breast cancer risk in a case-control study (464 cases, 624 controls) nested within the Nurses' Health Study cohort. We observed no a...

    Authors: Christopher A Haiman, Susan E Hankinson, Donna Spiegelman, Graham A Colditz, Walter C Willett, Frank E Speizer, Myles Brown and David J Hunter

    Citation: Breast Cancer Research 2000 2:378

    Content type: Research article

    Published on:

  2. Estrogen receptors are members of the nuclear receptor steroid family that exhibit specific structural features, ligand-binding domain sequence identity and dimeric interactions, that single them out. The crys...

    Authors: Marc Ruff, Monique Gangloff, Jean Marie Wurtz and Dino Moras

    Citation: Breast Cancer Research 2000 2:353

    Content type: Review

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  3. Natural, synthetic and environmental estrogens have numerous effects on the development and physiology of mammals. Estrogen is primarily known for its role in the development and functioning of the female repr...

    Authors: Sylvia Curtis Hewitt, John F Couse and Kenneth S Korach

    Citation: Breast Cancer Research 2000 2:345

    Content type: Review

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  4. Estrogens display intriguing tissue-selective action that is of great biomedical importance in the development of optimal therapeutics for the prevention and treatment of breast cancer, for menopausal hormone ...

    Authors: Benita S Katzenellenbogen and John A Katzenellenbogen

    Citation: Breast Cancer Research 2000 2:335

    Content type: Review

    Published on:

  5. Numerous models have been developed to address key elements in the biology of breast cancer development and progression. No model is ideal, but the most useful are those that reflect the natural history and hi...

    Authors: Gloria H Heppner, Fred R Miller and PV Malathy Shekhar

    Citation: Breast Cancer Research 2000 2:331

    Content type: Commentary

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  6. An association between protein glycosylation and tumorigenesis has been recognized for over 10 years. Associations linking the importance of glycosylation events to tumor biology, especially the progression to...

    Authors: Christine Couldrey and Jeffrey E Green

    Citation: Breast Cancer Research 2000 2:321

    Content type: Commentary

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  7. Protein truncation test (PTT) and single-strand conformation polymorphism (SSCP) assay were used to scan the BRCA1 and BRCA2 genes in 136 unrelated Italian breast/ovarian cancer patients. In the sample tested, BR...

    Authors: Laura Ottini, Cristina D'Amico, Cristiana Noviello, Salvatore Lauro, Maurizio Lalle, Giuseppe Fornarini, Orsola Anna Colantuoni, Claudia Pizzi, Enrico Cortesi, Sandro Carlini, Fiorella Guadagni, Angelo Raffaele Bianco, Luigi Frati, Alma Contegiacomo and Renato Mariani-Costantini

    Citation: Breast Cancer Research 2000 2:307

    Content type: Research article

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  8. Mammography is an effective screening modality for the early detection of breast cancer. The reduction in breast cancer mortality is greater for women aged over 50 at screening than for women aged under 50. Ma...

    Authors: Nick Day and Ruth Warren

    Citation: Breast Cancer Research 2000 2:247

    Content type: Commentary

    Published on:

  9. The acetyltransferase p300 was first identified associated with the adenoviral transforming protein E1A, suggesting a potential role for p300 in the regulation of cell proliferation. Direct evidence demonstrat...

    Authors: Andrew C Phillips and Karen H Vousden

    Citation: Breast Cancer Research 2000 2:244

    Content type: Commentary

    Published on:

  10. New guidelines for the collection and use of human tissues for research will impose new requirements on researchers to seek ethical approval and patient consent. This extends to the use of surplus tissue, such...

    Authors: Mitch Dowsett

    Citation: Breast Cancer Research 2000 2:241

    Content type: Commentary

    Published on:

  11. The use of human tissue, and material derived from such tissue, for research purposes is currently the subject of much debate. This debate needs to address several issues, including: the principle of abandonme...

    Authors: Wendy Prime, Mark E Sobel and C Simon Herrington

    Citation: Breast Cancer Research 2000 2:237

    Content type: Commentary

    Published on:

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