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  1. The fibroblast growth factor receptor (FGFR)2 gene has been shown to be amplified in 5-10% of breast cancer patients. A breast cancer cell line developed in our laboratory, SUM-52PE, was shown to have a 12-fol...

    Authors: Stacey L Tannheimer, Alnawaz Rehemtulla and Stephen P Ethier

    Citation: Breast Cancer Research 2000 2:311

    Content type: Research article

    Published on:

  2. Protein truncation test (PTT) and single-strand conformation polymorphism (SSCP) assay were used to scan the BRCA1 and BRCA2 genes in 136 unrelated Italian breast/ovarian cancer patients. In the sample tested, BR...

    Authors: Laura Ottini, Cristina D'Amico, Cristiana Noviello, Salvatore Lauro, Maurizio Lalle, Giuseppe Fornarini, Orsola Anna Colantuoni, Claudia Pizzi, Enrico Cortesi, Sandro Carlini, Fiorella Guadagni, Angelo Raffaele Bianco, Luigi Frati, Alma Contegiacomo and Renato Mariani-Costantini

    Citation: Breast Cancer Research 2000 2:307

    Content type: Research article

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  3. Mammography is an effective screening modality for the early detection of breast cancer. The reduction in breast cancer mortality is greater for women aged over 50 at screening than for women aged under 50. Ma...

    Authors: Nick Day and Ruth Warren

    Citation: Breast Cancer Research 2000 2:247

    Content type: Commentary

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  4. The acetyltransferase p300 was first identified associated with the adenoviral transforming protein E1A, suggesting a potential role for p300 in the regulation of cell proliferation. Direct evidence demonstrat...

    Authors: Andrew C Phillips and Karen H Vousden

    Citation: Breast Cancer Research 2000 2:244

    Content type: Commentary

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  5. New guidelines for the collection and use of human tissues for research will impose new requirements on researchers to seek ethical approval and patient consent. This extends to the use of surplus tissue, such...

    Authors: Mitch Dowsett

    Citation: Breast Cancer Research 2000 2:241

    Content type: Commentary

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  6. The use of human tissue, and material derived from such tissue, for research purposes is currently the subject of much debate. This debate needs to address several issues, including: the principle of abandonme...

    Authors: Wendy Prime, Mark E Sobel and C Simon Herrington

    Citation: Breast Cancer Research 2000 2:237

    Content type: Commentary

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  7. We describe here the expression pattern of the breast cell growthinhibitor Mammastatin in normal and breast cancer cells. Normal Cells (NHMC)over-express Mammastatin in low calcium media. Mammastatin has been ...

    Authors: Paul R Ervin Jr, Rebecca L Johnston, Milena Cankovic, David McDonagh and Neil Chi

    Citation: Breast Cancer Research 2000 2:E009

    Content type: Non-peer-reviewed research

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  8. This paper describes the derivation and characterization of a novel, conditionally immortal mammary epithelial cell line named KIM-2. These cells were derived from mid-pregnant mammary glands of a mouse harbou...

    Authors: Katrina E Gordon, Bert Binas, Rachel S Chapman, Kathreena M Kurian, Richard W E Clarkson, A John Clark, E Birgitte Lane and Christine J Watson

    Citation: Breast Cancer Research 2000 2:222

    Content type: Research article

    Published on:

  9. The ability of growth factors and their cognate receptors to induce mammary epithelial proliferation and differentiation is dependent on their ability to activate a number of specific signal transduction pathw...

    Authors: Eran R Andrechek and William J Muller

    Citation: Breast Cancer Research 2000 2:211

    Content type: Review

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  10. Both the non-receptor tyrosine kinase, c-Src, and members of the epidermal growth factor (EGF) receptor family are overexpressed in high percentages of human breast cancers. Because these molecules are plasma ...

    Authors: Jacqueline S Biscardi, Rumey C Ishizawar, Corinne M Silva and Sarah J Parsons

    Citation: Breast Cancer Research 2000 2:203

    Content type: Review

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  11. The past decade has seen the definition of key signalling pathways downstream of receptor tyrosine kinases (RTKs) in terms of their components and the protein-protein interactions that facilitate signal transd...

    Authors: Rania Kairouz and Roger J Daly

    Citation: Breast Cancer Research 2000 2:197

    Content type: Review

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  12. The fibroblast growth factors [Fgfs (murine), FGFs (human)] constitute a large family of ligands that signal through a class of cell-surface tyrosine kinase receptors. Fgf signalling has been associated in vitro ...

    Authors: Clive Dickson, Bradley Spencer-Dene, Christian Dillon and Vera Fantl

    Citation: Breast Cancer Research 2000 2:191

    Content type: Review

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  13. Cross-communication between different signalling systems is critical for the integration of multiple and changing environmental influences on individual cells. The epidermal growth factor receptor (EGFR) has b...

    Authors: Norbert Prenzel, Esther Zwick, Michael Leserer and Axel Ullrich

    Citation: Breast Cancer Research 2000 2:184

    Content type: Review

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  14. Cells are continuously exposed to diverse stimuli ranging from soluble endocrine and paracrine factors to signalling molecules on neighbouring cells. Receptors of the tyrosine kinase family play an important r...

    Authors: Nancy E Hynes

    Citation: Breast Cancer Research 2000 2:154

    Content type: Commentary

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  15. The mammary epithelium undergoes cyclical periods of cellular proliferation, differentiation and regression. These processes are under the control of the hormones secreted during pregnancy, lactation and invol...

    Authors: Bernd Groner and Lothar Hennighausen

    Citation: Breast Cancer Research 2000 2:149

    Content type: Commentary

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  16. We previously reported that ductal infiltrating carcinomas (DIC) of the human breast display profound modifications of the stromal architecture, associated with anomalous collagen composition. The major altera...

    Authors: Ida Pucci-Minafra, Cintia Carella, Rosalia Cirincione, Silvana Chimenti, Salvatore Minafra and Claudio Luparello

    Citation: Breast Cancer Research 2000 2:E008

    Content type: Non-peer-reviewed research

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  17. We tested the hypothesis that BRCA1 may play a role in the regulation of ovarian tumor cell death as well as the inhibition of ovarian cell proliferation. Introduction of BRCA1 antisense retroviral constructs ...

    Authors: Lois A Annab, Rebecca Hawkins, Greg Solomon, J Carl Barrett and Cynthia A Afshari

    Citation: Breast Cancer Research 2000 2:139

    Content type: Research article

    Published on:

  18. Altered responsiveness to extracellular signals and cell cycle dysregulation are hallmarks of cancer. The cell cycle is governed by cyclin-dependent kinases (cdks) that integrate mitogenic and growth inhibitor...

    Authors: Jeffrey Donovan and Joyce Slingerland

    Citation: Breast Cancer Research 2000 2:116

    Content type: Review

    Published on:

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