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  1. Content type: Research article

    We assessed the association between a glutamine repeat polymorphism in AIB1 and breast cancer risk in a case-control study (464 cases, 624 controls) nested within the Nurses' Health Study cohort. We observed no a...

    Authors: Christopher A Haiman, Susan E Hankinson, Donna Spiegelman, Graham A Colditz, Walter C Willett, Frank E Speizer, Myles Brown and David J Hunter

    Citation: Breast Cancer Research 2000 2:378

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  2. Content type: Review

    Estrogen receptors are members of the nuclear receptor steroid family that exhibit specific structural features, ligand-binding domain sequence identity and dimeric interactions, that single them out. The crys...

    Authors: Marc Ruff, Monique Gangloff, Jean Marie Wurtz and Dino Moras

    Citation: Breast Cancer Research 2000 2:353

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  3. Content type: Review

    Natural, synthetic and environmental estrogens have numerous effects on the development and physiology of mammals. Estrogen is primarily known for its role in the development and functioning of the female repr...

    Authors: Sylvia Curtis Hewitt, John F Couse and Kenneth S Korach

    Citation: Breast Cancer Research 2000 2:345

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  4. Content type: Review

    Estrogens display intriguing tissue-selective action that is of great biomedical importance in the development of optimal therapeutics for the prevention and treatment of breast cancer, for menopausal hormone ...

    Authors: Benita S Katzenellenbogen and John A Katzenellenbogen

    Citation: Breast Cancer Research 2000 2:335

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  5. Content type: Commentary

    Numerous models have been developed to address key elements in the biology of breast cancer development and progression. No model is ideal, but the most useful are those that reflect the natural history and hi...

    Authors: Gloria H Heppner, Fred R Miller and PV Malathy Shekhar

    Citation: Breast Cancer Research 2000 2:331

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  6. Content type: Commentary

    An association between protein glycosylation and tumorigenesis has been recognized for over 10 years. Associations linking the importance of glycosylation events to tumor biology, especially the progression to...

    Authors: Christine Couldrey and Jeffrey E Green

    Citation: Breast Cancer Research 2000 2:321

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  7. Content type: Research article

    The fibroblast growth factor receptor (FGFR)2 gene has been shown to be amplified in 5-10% of breast cancer patients. A breast cancer cell line developed in our laboratory, SUM-52PE, was shown to have a 12-fol...

    Authors: Stacey L Tannheimer, Alnawaz Rehemtulla and Stephen P Ethier

    Citation: Breast Cancer Research 2000 2:311

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  8. Content type: Research article

    Protein truncation test (PTT) and single-strand conformation polymorphism (SSCP) assay were used to scan the BRCA1 and BRCA2 genes in 136 unrelated Italian breast/ovarian cancer patients. In the sample tested, BR...

    Authors: Laura Ottini, Cristina D'Amico, Cristiana Noviello, Salvatore Lauro, Maurizio Lalle, Giuseppe Fornarini, Orsola Anna Colantuoni, Claudia Pizzi, Enrico Cortesi, Sandro Carlini, Fiorella Guadagni, Angelo Raffaele Bianco, Luigi Frati, Alma Contegiacomo and Renato Mariani-Costantini

    Citation: Breast Cancer Research 2000 2:307

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  9. Content type: Commentary

    Mammography is an effective screening modality for the early detection of breast cancer. The reduction in breast cancer mortality is greater for women aged over 50 at screening than for women aged under 50. Ma...

    Authors: Nick Day and Ruth Warren

    Citation: Breast Cancer Research 2000 2:247

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  10. Content type: Commentary

    The acetyltransferase p300 was first identified associated with the adenoviral transforming protein E1A, suggesting a potential role for p300 in the regulation of cell proliferation. Direct evidence demonstrat...

    Authors: Andrew C Phillips and Karen H Vousden

    Citation: Breast Cancer Research 2000 2:244

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  11. Content type: Commentary

    New guidelines for the collection and use of human tissues for research will impose new requirements on researchers to seek ethical approval and patient consent. This extends to the use of surplus tissue, such...

    Authors: Mitch Dowsett

    Citation: Breast Cancer Research 2000 2:241

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  12. Content type: Commentary

    The use of human tissue, and material derived from such tissue, for research purposes is currently the subject of much debate. This debate needs to address several issues, including: the principle of abandonme...

    Authors: Wendy Prime, Mark E Sobel and C Simon Herrington

    Citation: Breast Cancer Research 2000 2:237

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  13. Content type: Non-peer-reviewed research

    We describe here the expression pattern of the breast cell growthinhibitor Mammastatin in normal and breast cancer cells. Normal Cells (NHMC)over-express Mammastatin in low calcium media. Mammastatin has been ...

    Authors: Paul R Ervin Jr, Rebecca L Johnston, Milena Cankovic, David McDonagh and Neil Chi

    Citation: Breast Cancer Research 2000 2:E009

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  14. Content type: Research article

    This paper describes the derivation and characterization of a novel, conditionally immortal mammary epithelial cell line named KIM-2. These cells were derived from mid-pregnant mammary glands of a mouse harbou...

    Authors: Katrina E Gordon, Bert Binas, Rachel S Chapman, Kathreena M Kurian, Richard W E Clarkson, A John Clark, E Birgitte Lane and Christine J Watson

    Citation: Breast Cancer Research 2000 2:222

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  15. Content type: Review

    The ability of growth factors and their cognate receptors to induce mammary epithelial proliferation and differentiation is dependent on their ability to activate a number of specific signal transduction pathw...

    Authors: Eran R Andrechek and William J Muller

    Citation: Breast Cancer Research 2000 2:211

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  16. Content type: Review

    Both the non-receptor tyrosine kinase, c-Src, and members of the epidermal growth factor (EGF) receptor family are overexpressed in high percentages of human breast cancers. Because these molecules are plasma ...

    Authors: Jacqueline S Biscardi, Rumey C Ishizawar, Corinne M Silva and Sarah J Parsons

    Citation: Breast Cancer Research 2000 2:203

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  17. Content type: Review

    The past decade has seen the definition of key signalling pathways downstream of receptor tyrosine kinases (RTKs) in terms of their components and the protein-protein interactions that facilitate signal transd...

    Authors: Rania Kairouz and Roger J Daly

    Citation: Breast Cancer Research 2000 2:197

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  18. Content type: Review

    The fibroblast growth factors [Fgfs (murine), FGFs (human)] constitute a large family of ligands that signal through a class of cell-surface tyrosine kinase receptors. Fgf signalling has been associated in vitro ...

    Authors: Clive Dickson, Bradley Spencer-Dene, Christian Dillon and Vera Fantl

    Citation: Breast Cancer Research 2000 2:191

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  19. Content type: Review

    Cross-communication between different signalling systems is critical for the integration of multiple and changing environmental influences on individual cells. The epidermal growth factor receptor (EGFR) has b...

    Authors: Norbert Prenzel, Esther Zwick, Michael Leserer and Axel Ullrich

    Citation: Breast Cancer Research 2000 2:184

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  20. Content type: Commentary

    Cells are continuously exposed to diverse stimuli ranging from soluble endocrine and paracrine factors to signalling molecules on neighbouring cells. Receptors of the tyrosine kinase family play an important r...

    Authors: Nancy E Hynes

    Citation: Breast Cancer Research 2000 2:154

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  21. Content type: Commentary

    The mammary epithelium undergoes cyclical periods of cellular proliferation, differentiation and regression. These processes are under the control of the hormones secreted during pregnancy, lactation and invol...

    Authors: Bernd Groner and Lothar Hennighausen

    Citation: Breast Cancer Research 2000 2:149

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  22. Content type: Non-peer-reviewed research

    We previously reported that ductal infiltrating carcinomas (DIC) of the human breast display profound modifications of the stromal architecture, associated with anomalous collagen composition. The major altera...

    Authors: Ida Pucci-Minafra, Cintia Carella, Rosalia Cirincione, Silvana Chimenti, Salvatore Minafra and Claudio Luparello

    Citation: Breast Cancer Research 2000 2:E008

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  23. Content type: Research article

    We tested the hypothesis that BRCA1 may play a role in the regulation of ovarian tumor cell death as well as the inhibition of ovarian cell proliferation. Introduction of BRCA1 antisense retroviral constructs ...

    Authors: Lois A Annab, Rebecca Hawkins, Greg Solomon, J Carl Barrett and Cynthia A Afshari

    Citation: Breast Cancer Research 2000 2:139

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  24. Content type: Review

    Altered responsiveness to extracellular signals and cell cycle dysregulation are hallmarks of cancer. The cell cycle is governed by cyclin-dependent kinases (cdks) that integrate mitogenic and growth inhibitor...

    Authors: Jeffrey Donovan and Joyce Slingerland

    Citation: Breast Cancer Research 2000 2:116

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