Volume 10 Supplement 2

Breast Cancer Research 2008

Meeting abstracts

Breast Cancer Research 2008. Go to conference site.

London, UK13 May 2008

Page 2 of 3

Zinc transporter HKE4 as a new target in antihormone resistance of breast cancer

Authors: KM Taylor, N Jordan, S Hiscox, JM Gee and RI Nicholson

Citation: Breast Cancer Research 2008 10(Suppl 2):P42

Content type: Poster presentation Published on: 13 May 2008
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Stromal fibroblasts with nuclear β-catenin are present within breast tumours and increase proliferation and invasion of epithelial breast cancer cells

Authors: E Verghese, HG Shenoy, AM Shaaban, A Waterworth, MB Peter, K Horgan, V Speirs, AM Hanby and TA Hughes

Citation: Breast Cancer Research 2008 10(Suppl 2):P43

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Proapoptotic protein Bid is regulated by phosphorylation during anoikis and the cell cycle

Authors: J Lindsay and AP Gilmore

Citation: Breast Cancer Research 2008 10(Suppl 2):P44

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Breast cancer and environmental risk factors: an appraisal of the scientific evidence

Authors: A Kortenkamp

Citation: Breast Cancer Research 2008 10(Suppl 2):P45

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Assessment of angiogenesis in the hyperplasia preinvasive, invasive breast carcinoma sequence

Authors: JE Bluff, SS Cross, NJ Brown, MW Reed and CA Staton

Citation: Breast Cancer Research 2008 10(Suppl 2):P46

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Altered myoepithelial cell expression and function in cancer-containing breasts

Authors: V Modes, CM Rodrigues, N Nyquist, JA Shaw, JL Jones and RA Walker

Citation: Breast Cancer Research 2008 10(Suppl 2):P47

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Association of gene variants in the TGF-beta signalling pathways with invasive breast cancer risk

Authors: S Scollen, AM Dunning, AC Bradshaw, R Hesketh and JC Metcalfe

Citation: Breast Cancer Research 2008 10(Suppl 2):P48

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From association to cause: fine mapping of the TNRC9gene region, a novel susceptibility locus identified in the first genome-wide association study for breast cancer

Authors: S Ahmed, M Maranian, CS Gregory, M Udler, HI Field, J Tyrer, R Hesketh, JC Metcalfe, S Scollen, JP Stuewing, BAJ Ponder, PDP Pharoah, DF Easton and AM Dunning

Citation: Breast Cancer Research 2008 10(Suppl 2):P49

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Cytochrome P450 modulates the therapeutic actions of tamoxifen, as evidenced in novel breast cancer models

Authors: E Polson, S Weidlich, A Stenhouse and T Friedberg

Citation: Breast Cancer Research 2008 10(Suppl 2):P50

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Multicentre study of CASP8 polymorphisms in breast cancer

Authors: N Shephard, I Brock, N Camp, L Canon-Albright, B Frank, B Burwinkel and A Cox

Citation: Breast Cancer Research 2008 10(Suppl 2):P51

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Abnormal expression of p53 isoforms can be associated with poor survival in primary breast tumours

Authors: J-C Bourdon

Citation: Breast Cancer Research 2008 10(Suppl 2):P52

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The effect of intermittent versus chronic energy restriction on breast cancer risk biomarkers in premenopausal women: a randomised pilot trial

Authors: M Harvie, M Chapman, J Cuzick, A Flyvbjerg, P Hopwood, S Jebb, G Parfitt and A Howell

Citation: Breast Cancer Research 2008 10(Suppl 2):P53

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Living with genetic risk of breast cancer: what have we learned?

Authors: C Foster

Citation: Breast Cancer Research 2008 10(Suppl 2):P54

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Urinary and serum biomarkers of phytoestrogen exposure are not associated with breast cancer risk in the European Prospective into Cancer Norfolk study

Authors: H Ward, G Chapelais, GGC Kuhnle, R Luben, KT Khaw and S Bingham

Citation: Breast Cancer Research 2008 10(Suppl 2):P55

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Adherence to hormone therapy in a chemoprevention randomised trial

Authors: L Atkins, V Jenkins, L Fallowfield and A Howell

Citation: Breast Cancer Research 2008 10(Suppl 2):P56

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Health inequalities in breast cancer screening

Authors: J Tollitt, A Jain and S Astley

Citation: Breast Cancer Research 2008 10(Suppl 2):P57

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MCPH1, a potential predictor for response to cancer chemotherapy

Authors: SM Bell, V Speirs and EE Morrison

Citation: Breast Cancer Research 2008 10(Suppl 2):P58

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Quantitative proteomics reveals proteins associated with radiotherapy resistance in breast cancer cells

Authors: L Smith, D Potts, O Qutob, MB Watson, AW Beavis, MJ Lind, PJ Drew and L Cawkwell

Citation: Breast Cancer Research 2008 10(Suppl 2):P59

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Identification of proteins associated with radiotherapy resistance in breast cancer cells: a combined proteomic and microarray screening approach

Authors: L Smith, O Qutob, MB Watson, AW Beavis, JKA Jameel, KJ Welham, PJ Drew, MJ Lind and L Cawkwell

Citation: Breast Cancer Research 2008 10(Suppl 2):P60

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Proteomic screening of 725 antibodies simultaneously using antibody microarray technology to identify proteins associated with radiotherapy resistance in breast cancer cells

Authors: L Smith, O Qutob, MB Watson, AW Beavis, MJ Lind, PJ Drew and L Cawkwell

Citation: Breast Cancer Research 2008 10(Suppl 2):P61

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Development of anti-MUC1 DNA aptamers for the imaging and radiotherapy of breast cancer

Authors: C Da Pieve, JN Iley, A Perkins and S Missailidis

Citation: Breast Cancer Research 2008 10(Suppl 2):P62

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Prognostic significance of steroid receptor co-regulators in breast cancer: co-repressor NCOR2/SMRT is an independent indicator of poor outcome

Authors: AR Green, C Burney, CJ Granger, EC Paish, S El-Sheikh, EA Rakha, DG Powe, RD Macmillan, IO Ellis and E Stylianou

Citation: Breast Cancer Research 2008 10(Suppl 2):P63

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High-throughput optical proteomics and breast cancer patient profiling: novel applications to individualise prognosis and treatment

Authors: MT Kelleher, F Festy, C Gillett, SE Pinder, S Ameer-Beg, EO Fo, PA Ellis and T Ng

Citation: Breast Cancer Research 2008 10(Suppl 2):P64

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Expression analysis of novel biomarkers for breast cancer

Authors: SA Laversin, AK Miles, GR Ball, AD Gritzapis, S Perez, C Baxevanis, G Li and RC Rees

Citation: Breast Cancer Research 2008 10(Suppl 2):P65

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Identification and role of migration stimulating factor isoforms in breast carcinomas

Authors: AM Schor, IR Ellis, SJ Jones, S Perrier, MM Florence, J Cox, G Ohe, K Kankova, B Vojtesek, AM Thompson, C Purdie, S Kazmi, S Foo, AM Woolston and SL Schor

Citation: Breast Cancer Research 2008 10(Suppl 2):P66

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Development of functional assays for BRCA1 missense mutations

Authors: A Sturdy, D Finch, R Naseem, D Trump, G Evens and M Webb

Citation: Breast Cancer Research 2008 10(Suppl 2):P67

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Chemotherapy-induced modulation of [¹⁸F]Fluoro-2-deoxy-D-glucose incorporation at the tumour cell level

Authors: RI Sharma, RW Cheyne, SA Suttie and TAD Smith

Citation: Breast Cancer Research 2008 10(Suppl 2):P68

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Identification and definition of novel clinical phenotypes of breast cancer through consensus derived from automated clustering methods

Authors: AR Green, JM Garibaldi, D Soria, F Ambrogi, G Ball, PJG Lisboa, TA Etchells, P Boracchi, E Biganzoli, RD Macmillan, RW Blamey, DG Powe, EA Rakha and IO Ellis

Citation: Breast Cancer Research 2008 10(Suppl 2):P69

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Detection of gene amplification in matched tumour and plasma DNA from breast cancer patients by quantitative PCR

Authors: K Page, N Hava, MJ Slade, RA Walker, RC Coombes and JA Shaw

Citation: Breast Cancer Research 2008 10(Suppl 2):P70

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Prospective Study of Outcome in Sporadic versus Hereditary Breast Cancer: pros and cons of running a cohort study

Authors: SM Gerty, PD Simmonds, L Durcan and DM Eccles

Citation: Breast Cancer Research 2008 10(Suppl 2):P71

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Lymphovascular invasion in breast cancer: improved methods of detection and clinical significance

Authors: RAA Mohammed, SG Martin, MS Gill, AR Green, EC Paish and IO Ellis

Citation: Breast Cancer Research 2008 10(Suppl 2):P72

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TARGIT: an international trial of intraoperative versus external beam radiotherapy

Authors: M Baum, N Williams, J Vaidya, M Keshtgar and J Tobias

Citation: Breast Cancer Research 2008 10(Suppl 2):P73

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Cambridge Breast Intensity Modulated Radiotherapy Trial: dosimetry results for 1,139 patients

Authors: CE Coles, JS Wilkinson, CB Wilson, NG Burnet, GC Wishart, N Twyman, ACF Hoole and AM Moody

Citation: Breast Cancer Research 2008 10(Suppl 2):P74

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Bevacizumab resistance in breast cancer: are neuropilins the key?

Authors: CA Staton, Z Yang, MWR Reed and NJ Brown

Citation: Breast Cancer Research 2008 10(Suppl 2):P75

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Brk expression may affect the differentiation status of breast cancer cells

Authors: AJ Harvey, CJ Pennington, DR Edwards, SA Eccles and MR Crompton

Citation: Breast Cancer Research 2008 10(Suppl 2):P76

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C35 overexpression defines subsets of human breast cancer and its immunoreceptor tyrosine-based activation motif represents a novel treatment target

Authors: E Katz, D Faratian, JMS Bartlett, K MacLeod, H Pedersen, A Larionov, EM Smith, AP Howell, JM Dixon, EE Evans, SP Langdon and DJ Harrison

Citation: Breast Cancer Research 2008 10(Suppl 2):P77

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Why do most c-erbB-2/HER-2-positive breast cancer patients fail to respond to Herceptin?

Authors: ML Murphy, SKW Chan and WJ Gullick

Citation: Breast Cancer Research 2008 10(Suppl 2):P78

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Identification of components of the ubiquitin system as targets for therapeutic intervention

Authors: MK Saville

Citation: Breast Cancer Research 2008 10(Suppl 2):P79

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Pretreatment of breast cancer cells with doxorubicin facilitates the subsequent uptake of zoledronic acid

Authors: DV Lefley, I Holen, RE Coleman and PD Ottewell

Citation: Breast Cancer Research 2008 10(Suppl 2):P80

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Mechanisms of apoptosis and cell-cycle arrest in subcutaneous breast tumours treated sequentially with doxorubicin followed by zoledronic acid

Authors: PD Ottewell, DV Lefley, RE Coleman and I Holen

Citation: Breast Cancer Research 2008 10(Suppl 2):P81

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An exploration of the management of menopausal symptoms for women with a diagnosis of breast cancer: lay and professional experiences and expectations

Authors: S Cruickshank, A Hume and EM Alder

Citation: Breast Cancer Research 2008 10(Suppl 2):P82

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Investigation of immunoregulatory mechanisms relating to poor surgical wound healing and breast cancer recurrence

Authors: BV Hogan, HG Shenoy, MB Peter, NM Orsi, C Carter, K Horgan and TA Hughes

Citation: Breast Cancer Research 2008 10(Suppl 2):P83

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Discrepancies and challenge of ductal carcinoma in situfor health professionals

Authors: F Kennedy, D Harcourt and N Rumsey

Citation: Breast Cancer Research 2008 10(Suppl 2):P84

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Exploring the breast cancer experiences, needs and preferences of women aged 70 years and over: a study in progress

Authors: J Moffat, C Foster, D Fenlon and J Addington-Hall

Citation: Breast Cancer Research 2008 10(Suppl 2):P85

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Exploring the acceptability of, and preferences for, an ongoing support network for known BRCA1 and BRCA2 mutation carriers

Authors: L Hughes, C Phelps and M Rogers

Citation: Breast Cancer Research 2008 10(Suppl 2):P86

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The QUEST study: a multicentre randomised trial to assess the impact of the type and timing of breast reconstruction on quality of life following mastectomy

Authors: S Potter and ZE Winters

Citation: Breast Cancer Research 2008 10(Suppl 2):P87

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'The sooner the better' or 'too much too soon'? A pilot prospective longitudinal study to evaluate quality of life and body image following immediate latissimus dorsi breast reconstruction

Authors: S Potter, HJ Thomson, LJ Fallowfield and ZE Winters

Citation: Breast Cancer Research 2008 10(Suppl 2):P88

Content type: Poster presentation Published on: 13 May 2008
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Diagnosed with breast cancer whilst on a family history screening programme: an exploratory qualitative study

Authors: A Clements, B Henderson, S Tyndel, G Evans, K Brain, E Watson and J Austoker

Citation: Breast Cancer Research 2008 10(Suppl 2):P89

Content type: Poster presentation Published on: 13 May 2008
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'More positive about mammography' – reactions of women to a false positive recall: a qualitative study of women at risk of familial breast cancer

Authors: A Clements, S Tyndel, B Henderson, K Brain, E Watson and J Austoker

Citation: Breast Cancer Research 2008 10(Suppl 2):P90

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What is the psychological impact of mammographic screening on younger women with a family history of breast cancer? Findings from a prospective cohort study (PIMMS)

Authors: S Tyndel, J Austoker, BJ Henderson, K Brain, C Bankhead, A Clements and E Watson

Citation: Breast Cancer Research 2008 10(Suppl 2):P91

Content type: Poster presentation Published on: 13 May 2008
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