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Fig. 8 | Breast Cancer Research

Fig. 8

From: S100A6 inhibits MDM2 to suppress breast cancer growth and enhance sensitivity to chemotherapy

Fig. 8

Proposed model for the regulation of MDM2 by S100A6. S100A6 promotes the translocation of MDM2 from the nucleus to the cytoplasm. In the cytoplasm, S100A6 binds to the binding site of HAUSP in MDM2, disrupting the MDM2–HAUSP–DAXX interactions and inducing the MDM2 self-ubiquitination and degradation, thereby suppressing the breast cancer growth and enhancing its sensitivity to chemotherapy

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