Fig. 1
From: S100A6 inhibits MDM2 to suppress breast cancer growth and enhance sensitivity to chemotherapy
S100A6 inhibits MDM2 in breast cancer cell lines. A The expression levels of S100A6 and MDM2 in SUM159, MCF-7, ZR-75–1, MDA-MB-231, MDA-MB-468, and HCC1937. Correlation of the expressions of S100A6 and MDM2. B and D Expressions of MDM2 in MCF-7 and ZR-75–1 versus MDA-MB-231 and HCC1937 under the transfection of S100A6 (5 μg, S100A6 plasmid) and S100A6 siRNA (5 μg, siS100A6), respectively. C Dose–response expression of MDM2 in MCF-7 after S100A6 transfection. Histograms showed the densitometric analyses of indicated proteins. Data were shown as mean ± SD; n = 3 independent experiments. *P < 0.05, **P < 0.01, and ***P < 0.001