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Fig. 6 | Breast Cancer Research

Fig. 6

From: Integration of multiomics data shows down regulation of mismatch repair and tubulin pathways in triple-negative chemotherapy-resistant breast tumors

Fig. 6

Expression profile of genes that distinguishes early recurrence in post-NAC biopsies. A BEAUTY expression profiles of the seventeen genes were observed to be differentially expressed with respect to the ERC in TNBC post-NAC biopsies (left panel). However, none of these genes were observed to be differentially expressed among the ERC in the pre-NAC biopsies (right panel). Four genes (FHL2, TANK, PDE2A, and RSPO3) are related to immune response signaling, and they were down regulated in the post-NAC samples of the ERC group. B TCGA TNBC expression profiles were confirmed to arise from tumor tissues compared to the paired normal-adjacent reference tissues. Bar plot shows the log fold changes (logFC) from all TCGA TNBC samples versus their paired normal adjacent tissues (left panel) Moreover, the expression profile was specific to TCGA non-LAR TNBC tumors as depicted by their logFC compared to respective paired normal adjacent samples (right panel). (Additional file 1: Figures s3-s6)

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