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Fig. 5 | Breast Cancer Research

Fig. 5

From: Carbonic anhydrases reduce the acidity of the tumor microenvironment, promote immune infiltration, decelerate tumor growth, and improve survival in ErbB2/HER2-enriched breast cancer

Fig. 5

Carbonic anhydrase isoforms CA9, with known extracellular expression, and CA13, with known cytosolic expression, negatively predict prognosis for patients with Basal-like breast cancer. A-L Survival curves for patients (n = 442–1188) with Basal-like breast cancer stratified for mRNA expression of each carbonic anhydrase isoform. The color coding of the curves distinguishes carbonic anhydrase isoforms with known extracellular or secreted (red), cytosolic (green), and mitochondrial (blue) expression. The ticks on the curves indicate censored subjects. Low and high mRNA levels refer to z-scores below and above zero, respectively. Data were compared by Mantel–Cox and Gehan–Breslow–Wilcoxon tests. HR, hazard ratio

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