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Table 4 Association of alcohol use with percentage of breast tissue composition (log-transformed) in benign breast biopsy samples, postmenopausal controls only (Adjusted for age (continuous), BMI (continuous), a family history of breast cancer (Yes/No), postmenopausal hormone use (none, past, current, unknown), age at menopause (< 46, 46–< 50, 50–< 55, ≥ 55, unknown), age at menarche (< 12, 12, 13, > 13, unknown), combined parity/age at first birth (parous with first birth before age 25, parous with first birth at or after age 25, nulliparous, unknown), BBD category (non-proliferative, proliferative without atypia, and proliferative with atypia), and NHS cohort (NHSI, NHSII)

From: Associations of alcohol consumption with breast tissue composition

Alcohol use

N

% Epithelial

% Stroma

% Fat

% Fibroglandulara

Continuous alcohol at BBD per 11 g or one drink

254

− 0.05 (− 0.16; 0.06)

− 0.04 (− 0.07; − 0.01)

0.21 (0.05; 0.37)

− 0.04 (− 0.07; − 0.01)

Categorical alcohol at BBD

     

Non-drinker

96

Ref

Ref

Ref

Ref

< 11 g/day (< 1 drink/day)

108

0.02 (− 0.17; 0.22)

− 0.10 (− 0.15; − 0.05)

0.47 (0.19; 0.76)

− 0.09 (− 0.14; − 0.04)

11–< 22 g/day (1–< 2 drinks/day)

32

0.09 (− 0.19; 0.37)

− 0.08 (− 0.15; − 0.05)

0.40 (− 0.01; 0.81)

− 0.07 (− 0.14; − 0.11 × 10–2)

≥ 22 g/day (≥ 2 drinks/day)

18

− 0.31 (− 0.66; 0.04)

− 0.14 (− 0.24; − 0.05)

0.79 (0.28; 1.31)

− 0.16 (− 0.25; − 0.08)

p-trend

254

0.16

0.02

0.01

< 0.01

Continuous cumulative average alcohol, per 11 g or one drink

263

− 0.02 (− 0.13; 0.09)

− 0.05 (− 0.08; − 0.02

0.22 (0.05; 0.39)

− 0.05 (− 0.08; − 0.02)

Cumulative average alcohol

     

Non-drinker

70

Ref

Ref

Ref

Ref

< 11 g/day (< 1 drink/day)

140

− 0.05 (− 0.25; 0.14)

− 0.05 (− 0.10; 0.01)

0.13 (− 0.16; 0.43)

− 0.06 (− 0.11; − 0.01)

11–< 22 g/day (1–< 2 drinks/day)

40

0.05 (− 0.22; 0.31)

− 0.07 (− 0.15; − 0.01 × 10–2)

0.32 (− 0.08; 0.71)

− 0.05 (− 0.12; 0.01)

≥ 22 g/day (≥ 2 drinks/day)

13

− 0.14 (− 0.54; 0.27)

− 0.16 (− 0.28; − 0.05)

0.61 (0.01; 1.22)

− 0.18 (− 0.28; − 0.07)

p-trend

263

0.95

< 0.01

0.03

< 0.01

  1. aFibroglandular tissue represents combined epithelium and stroma