Table 1 Cohort characteristics. Statistical significance determined with Student’s t-test or Chi-square tests, excluding “Unknown” samples

Subjects [n(%)] 486

291

195

Age at diagnosis (yr) 53.1 ± 11.5

53.3 ± 11.4

52.8 ± 11.7

0.61

Histological subtype [n(%)]

Invasive ductal carcinoma

437

258 (59.0) [88.7]

179 (41.0) [91.8]

0.34

Invasive lobular carcinoma

17

16 (94.1) [5.5]

1 (5.9) [0.5]

3.1E−03

Other

14

5 (35.7) [1.7]

9 (64.3) [4.7]

0.064

Unknown

18

12 (66.7) [4.1]

6 (33.3) [3.1]

PAM50 subtypes [n(%)]

Luminal A

178

152 (85.4) [52.2]

26 (14.6) [13.3]

 < 2E−16

Luminal B

97

67 (69.1) [23.0]

30 (30.9) [15.4]

0.047

HER2-enriched

105

36 (34.3) [12.4]

69 (65.7) [35.4]

3.0E−09

Basal-like

92

30 (32.6) [10.3]

62 (67.4) [31.8]

6.3E−09

Normal-like

14

6 (42.9) [2.1]

8 (57.1) [4.1]

0.19

Tumour stage [n(%)]

0–1

83

51 (61.4) [17.5]

32 (38.6) [16.4]

0.73

2

221

136 (61.5) [46.7]

85 (38.5) 43.6]

0.45

3

147

80 (54.4) [27.5]

67 (45.6) [34.4]

0.11

4

16

12 (75.0) [4.1]

4 (25.0) [2.1]

0.21

Unknown

19

12 (63.2) [4.1]

7 (36.8) [3.6]

Tumour grade [n(%)]

1

11

11 (100) [3.8]

0 (0) [0]

0.021

2

208

160 (76.9) [55.0]

48 (23.1) [24.7]

6.1E−12

3

232

98 (42.2) [33.7]

134 (57.8) [68.7]

1.0E−13

Unknown

35

22 (62.9) [7.6]

13 (37.1) [6.7]