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Fig. 3 | Breast Cancer Research

Fig. 3

From: The WAVE3/β-catenin oncogenic signaling regulates chemoresistance in triple negative breast cancer

Fig. 3

Loss of WAVE3 expression or its phosphorylation in combination with chemotherapy, inhibits tumor growth in vivo. Quantification of volume (A, D) and weight (C, E) of tumors derived from implantation of parental MDA-MB-231 (A, C) and 4T1 cells (C, E) and their derivatives into the mammary fat pads of NSG mice for MDAMB-231 and Balb/c mice for 4T1 cells with or without treatment with doxorubicin (1 mg/kg). The vertical dark arrow indicates the initiation of the treatment. Data are generated from five mice per group and each mouse was injected in both the left and right mammary fat pad, resulting in ten tumors. Data are the mean ± SD (n = 10, **p < 0.01; Student’s t test). Comparisons and statistical analyses (**) were done between the untreated and the treated groups

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