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Table 2 Cox regression Hazard ratios for serum protein levels, in relation to survival

From: Serum immuno-oncology markers carry independent prognostic information in patients with newly diagnosed metastatic breast cancer, from a prospective observational study

 

Overall survival

Hazard ratio (95%CI)

Progression-free survival

Hazard ratio (95%CI)

Serum protein

Unadjusted

P value

q value

Adjusted

P value

q value

Unadjusted

P value

q value

Adjusted

P value

q value

ADA

–

–

–

–

–

–

2.13

(1.46–3.09)

 < 0.0001

0.0067

2.39

(1.38–4.16)

0.0020

0.1703

CASP8

–

–

–

–

–

–

1.65

(1.28–2.14)

0.00012

0.0099

1.73

(1.25–2.39)

0.00087

0.0786

CAIX

1.56

(1.27–1.93)

 < 0.0001

0.0017

1.44

(1.15–1.81)

0.0018

0.1399

–

–

–

–

–

–

CD244

0.57

(0.35–0.95)

0.030

0.9216

0.74

(0.37–1.49)

0.40

0.9818

0.50

(0.31–0.79)

0.0028

0.2250

0.50

(0.27–0.91)

0.022

0.9819

CD8A

–

–

–

–

–

–

0.91

(0.68–1.22)

0.55

0.9899

0.97

(0.64–1.46)

0.88

0.9819

CSF-1

11.16

(4.12–30.20)

 < 0.0001

0.0002

6.05

(1.59–23.00)

0.0083

0.5976

4.90

(2.24–10.68)

 < 0.0001

0.0059

5.00

(1.61–15.54)

0.0055

0.4584

FasL

0.58

(0.40–0.83)

0.0031

0.1862

0.47

(0.30–0.75)

0.0013

0.1060

–

–

–

–

–

–

IL-6

1.37

(1.21–1.56)

 < 0.0001

 < 0.0001

1.54

(1.14–2.10)

0.0056

0.4126

1.26

(1.11–1.43)

0.00029

0.0245

1.47

(1.11–1.93)

0.0068

0.5677

IL-8

1.47

(1.31–1.66)

 < 0.0001

 < 0.0001

1.63

(1.33–1.98)

 < 0.0001

0.0002

1.35

(1.20–1.53)

 < 0.0001

0.0001

1.44

(1.18–1.76)

0.00034

0.0310

IL-10

1.41

(1.19–1.66)

 < 0.0001

0.0058

1.42

(1.14–1.77)

0.0019

0.1492

1.32

(1.11–1.56)

0.0015

0.1176

1.35

(1.11–1.63)

0.0025

0.2114

MCP2

–

–

–

–

–

–

0.89

(0.68–1.16)

0.39

0.9899

0.88

(0.63–1.24)

0.47

0.9819

MUC16

1.40

(1.22–1.61)

 < 0.0001

0.0001

1.27

(1.05–1.55)

0.015

0.9818

1.23

(1.08–1.39)

0.0014

0.1157

1.22

(1.02–1.45)

0.029

0.9819

TFNSFR4

1.78

(1.29–2.46)

0.00043

0.0307

1.99

(1.23–3.23)

0.0054

0.4062

–

–

–

–

–

–

  1. The hazard ratio corresponds to a doubling of normalized protein expression values (NPX values), an arbitrary unit on a log2 scale
  2. q values are P values adjusted for multiple comparison (all 92 serum proteins) using false discovery rate (FDR)
  3. – denotes not relevant HRs since these are not top proteins selected for the respective outcome
  4. CI confidence interval
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Breast Cancer Research

ISSN: 1465-542X

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