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Fig. 4 | Breast Cancer Research

Fig. 4

From: MUC16 promotes triple-negative breast cancer lung metastasis by modulating RNA-binding protein ELAVL1/HUR

Fig. 4

Effect of MUC16 knockdown on TNBC lung metastasis. A. Representative IVIS image of scramble and MUC16 knockdown cells injected mice. B. Bar diagram and histological images were showing decreased percentage area of lung metastasis in nude mice injected with MUC16 knockdown (N = 5) as compared to scramble controls (N = 6). C, D. IHC images and corresponding quantification represent that decreased expression of MUC16 and HuR in MUC16 knockdown lung xenograft compared to control (20× magnification). E. Confocal image indicating decreased MUC16 and HuR expression in the MUC16 knockdown cells injected xenograft as compared to scramble control xenografts. F, G. qRT-PCR data showing upregulation of MUC16, and HuR in the MDA MB 231 lung tropic cells (LM2) as compared to parental MDA MB 231 cells

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