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Fig. 4 | Breast Cancer Research

Fig. 4

From: Molecular profiling of a real-world breast cancer cohort with genetically inferred ancestries reveals actionable tumor biology differences between European ancestry and African ancestry patient populations

Fig. 4

Differential Enrichment of Breast Cancer-Related Gene Sets in African and European Ancestry Patients (AA and EA, respectively). Violin plots depicting five gene sets from the hallmark and oncogenic signature collections that were considered particularly relevant to breast cancer biology, including: A ERBB2_UP.V1_UP, B LTE2_UP.V1_UP, C HALLMARK_ANDROGEN_RESPONSE, D HALLMARK_FATTY_ACID_METABOLISM, and E HALLMARK_ESTROGEN_RESPONSE_LATE. Only patients with stage IV HR+/HER2- disease exhibited differential enrichment in these gene sets (A–D), with the exception of the estrogen response pathway (E), which had no significantly different enrichment between ancestral groups

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Breast Cancer Research

ISSN: 1465-542X

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