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Table 1 Univariable and multivariable linear regression results for Ki67Baseline by HER2 status

From: Clinico-pathologic relationships with Ki67 and its change with short-term aromatase inhibitor treatment in primary ER + breast cancer: further results from the POETIC trial (CRUK/07/015)

 

ER + HER2-

ER + HER2 + 

Univariable

Multivariable

Univariable

Multivariable

β

Ci

p Value

β

ci

p Value

Adjusted critical value

β

ci

p Value

β

ci

p Value

Adjusted critical value

PgR Status

Positive

0

 < 0.001

0

0.038

0.043

0

0.980

0

0.366

0.029

Negative

0.21

0.12–0.31

0.11

0.02–0.20

0.20

0.02–0.38

0.11

− 0.06 to 0.29

Unknown

0.01

− 0.05 to 0.07

0.00

− 0.06 to 0.06

0.10

− 0.08 to 0.28

0.09

− 0.09 to 0.26

Tumour grade (baseline)

1

0

 < 0.001

0

 < 0.001

0.007

0

 < 0.001

0

 < 0.001

0.007

2

0.43

0.36–0.51

0.40

0.33–0.48

0.56

0.20–0.92

0.60

0.23–0.97

3

1.16

1.06–1.25

1.04

0.94–1.14

1.04

0.68–1.40

1.05

0.68–1.42

Not known

0.40

0.29–0.51

0.35

0.24–0.46

0.69

0.27–1.11

0.74

0.30–1.18

Tumour size (baseline)

0-2 cm

0

 < 0.001

(< 0.001)*

0

 < 0.001

0.021

0

0.167

(0.043)*

0

0.561

0.036

2-5 cm

0.24

0.18–0.30

0.14

0.08–0.20

0.14

− 0.01 to 0.29

0.07

− 0.08 to 0.22

 > 5 cm

0.28

0.08–0.49

0.11

− 0.08 to 0.31

0.23

− 0.46 to 0.91

− 0.13

− 0.80 to 0.54

Histological type (baseline)

Ductal

0

 < 0.001

0

 < 0.001

0.014

0

0.286

0

0.798

0.043

Lobular

− 0.30

− 0.38 to − 0.22

− 0.24

− 0.31 to − 0.16

− 0.07

− 0.40 to 0.25

0.07

− 0.21 to 0.35

Other

− 0.50

− 0.65 to − 0.35

− 0.24

− 0.39 to − 0.10

− 0.27

− 1.03 to 0.49

− 0.09

− 0.54 to 0.36

Nodal status

N0

0

 < 0.001

(< 0.001)*

0

0.008

0.036

0

0.431

(0.211)*

0

0.894

0.050

N1-3

0.10

0.03–0.16

0.00

− 0.06 to 0.06

0.06

− 0.11 to 0.24

0.02

− 0.15 to 0.19

N4 + 

0.32

0.23–0.42

0.14

0.05–0.24

0.13

− 0.08 to 0.33

− 0.03

− 0.25 to 0.19

Age group

 < 60

0.02

− 0.06 to 0.10

0.230

(0.059)

− 0.03

− 0.10 to 0.05

0.167

0.050

0.02

− 0.18 to 0.22

0.052

(0.791)*

0.07

− 0.12 to 0.26

0.183

0.021

60–69

0

0

0

0

70–79

0.04

− 0.03 to 0.11

− 0.01

− 0.07 to 0.06

0.15

− 0.03 to 0.34

0.12

− 0.06 to 0.30

80 + 

− 0.07

− 0.16 to 0.03

− 0.10

− 0.19 to − 0.01

− 0.25

− 0.52 to 0.02

− 0.17

− 0.44 to 0.10

Vascular invasion

Yes

0

 < 0.001

0

 < 0.001

0.029

0

0.068

0

0.117

0.143

No

− 0.34

− 0.41 to − 0.28

− 0.15

− 0.21 to − 0.08

− 0.17

− 0.32 to − 0.02

− 0.16

− 0.32 to 0.00

Not reported

− 0.24

− 0.38 to − 0.10

− 0.10

− 0.23 to 0.03

0.06

− 0.39 to 0.51

0.04

− 0.40 to 0.47

  1. *Test for trend
  2. Analysed as ln(Ki67 + 0.1)
  3. Adjusted critical values calculated using Benjamini Hochberg method. Significant p values following adjustment are highlighted in bold