ER + HER2- | ER + HER2 + | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Univariable | Multivariable | Univariable | Multivariable | |||||||||||
β | Ci | p Value | β | ci | p Value | Adjusted critical value | β | ci | p Value | β | ci | p Value | Adjusted critical value | |
PgR Status | ||||||||||||||
Positive | 0 | – | < 0.001 | 0 | – | 0.038 | 0.043 | 0 | – | 0.980 | 0 | – | 0.366 | 0.029 |
Negative | 0.21 | 0.12–0.31 | 0.11 | 0.02–0.20 | 0.20 | 0.02–0.38 | 0.11 | − 0.06 to 0.29 | ||||||
Unknown | 0.01 | − 0.05 to 0.07 | 0.00 | − 0.06 to 0.06 | 0.10 | − 0.08 to 0.28 | 0.09 | − 0.09 to 0.26 | ||||||
Tumour grade (baseline) | ||||||||||||||
1 | 0 | – | < 0.001 | 0 | – | < 0.001 | 0.007 | 0 | – | < 0.001 | 0 | – | < 0.001 | 0.007 |
2 | 0.43 | 0.36–0.51 | 0.40 | 0.33–0.48 | 0.56 | 0.20–0.92 | 0.60 | 0.23–0.97 | ||||||
3 | 1.16 | 1.06–1.25 | 1.04 | 0.94–1.14 | 1.04 | 0.68–1.40 | 1.05 | 0.68–1.42 | ||||||
Not known | 0.40 | 0.29–0.51 | 0.35 | 0.24–0.46 | 0.69 | 0.27–1.11 | 0.74 | 0.30–1.18 | ||||||
Tumour size (baseline) | ||||||||||||||
0-2 cm | 0 | – | < 0.001 (< 0.001)* | 0 | – | < 0.001 | 0.021 | 0 | − | 0.167 (0.043)* | 0 | – | 0.561 | 0.036 |
2-5 cm | 0.24 | 0.18–0.30 | 0.14 | 0.08–0.20 | 0.14 | − 0.01 to 0.29 | 0.07 | − 0.08 to 0.22 | ||||||
> 5 cm | 0.28 | 0.08–0.49 | 0.11 | − 0.08 to 0.31 | 0.23 | − 0.46 to 0.91 | − 0.13 | − 0.80 to 0.54 | ||||||
Histological type (baseline) | ||||||||||||||
Ductal | 0 | – | < 0.001 | 0 | – | < 0.001 | 0.014 | 0 | – | 0.286 | 0 | – | 0.798 | 0.043 |
Lobular | − 0.30 | − 0.38 to − 0.22 | − 0.24 | − 0.31 to − 0.16 | − 0.07 | − 0.40 to 0.25 | 0.07 | − 0.21 to 0.35 | ||||||
Other | − 0.50 | − 0.65 to − 0.35 | − 0.24 | − 0.39 to − 0.10 | − 0.27 | − 1.03 to 0.49 | − 0.09 | − 0.54 to 0.36 | ||||||
Nodal status | ||||||||||||||
N0 | 0 | – | < 0.001 (< 0.001)* | 0 | – | 0.008 | 0.036 | 0 | – | 0.431 (0.211)* | 0 | – | 0.894 | 0.050 |
N1-3 | 0.10 | 0.03–0.16 | 0.00 | − 0.06 to 0.06 | 0.06 | − 0.11 to 0.24 | 0.02 | − 0.15 to 0.19 | ||||||
N4 + | 0.32 | 0.23–0.42 | 0.14 | 0.05–0.24 | 0.13 | − 0.08 to 0.33 | − 0.03 | − 0.25 to 0.19 | ||||||
Age group | ||||||||||||||
< 60 | 0.02 | − 0.06 to 0.10 | 0.230 (0.059) | − 0.03 | − 0.10 to 0.05 | 0.167 | 0.050 | 0.02 | − 0.18 to 0.22 | 0.052 (0.791)* | 0.07 | − 0.12 to 0.26 | 0.183 | 0.021 |
60–69 | 0 | – | 0 | – | 0 | – | 0 | – | ||||||
70–79 | 0.04 | − 0.03 to 0.11 | − 0.01 | − 0.07 to 0.06 | 0.15 | − 0.03 to 0.34 | 0.12 | − 0.06 to 0.30 | ||||||
80 + | − 0.07 | − 0.16 to 0.03 | − 0.10 | − 0.19 to − 0.01 | − 0.25 | − 0.52 to 0.02 | − 0.17 | − 0.44 to 0.10 | ||||||
Vascular invasion | ||||||||||||||
Yes | 0 | – | < 0.001 | 0 | – | < 0.001 | 0.029 | 0 | – | 0.068 | 0 | – | 0.117 | 0.143 |
No | − 0.34 | − 0.41 to − 0.28 | − 0.15 | − 0.21 to − 0.08 | − 0.17 | − 0.32 to − 0.02 | − 0.16 | − 0.32 to 0.00 | ||||||
Not reported | − 0.24 | − 0.38 to − 0.10 | − 0.10 | − 0.23 to 0.03 | 0.06 | − 0.39 to 0.51 | 0.04 | − 0.40 to 0.47 |