OPG, all cases | ER-PR- | ER+ PR− or ER-PR + | ER + PR + | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
n/events | HRa | (95% CI) | p | n/events | HRb | (95% CI) | p | n/events | HRb | (95% CI) | p | n/events | HRb | (95% CI) | p | Phetc | |||||
All-cause mortality | |||||||||||||||||||||
Quartiles | 1 | 613/108 | ref. | 68/14 | ref. | 88/15 | ref. | 396/68 | ref. | ||||||||||||
2 | 614/102 | 0.85 | (0.65–1.12) | 79/16 | 0.94 | (0.45–1.99) | 103/20 | 1.08 | (0.54–2.13) | 370/56 | 0.84 | (0.59–1.20) | 0.44 | ||||||||
3 | 615/122 | 0.97 | (0.75–1.27) | 69/22 | 1.40 | (0.70–2.82) | 88/16 | 0.89 | (0.43–1.85) | 392/72 | 0.96 | (0.68–1.35) | |||||||||
4 | 614/152 | 1.21 | (0.93–1.56) | 93/34 | 1.75 | (0.90–3.40) | 88/23 | 1.58 | (0.81–3.06) | 377/85 | 1.09 | (0.78–1.52) | |||||||||
Continuousd | 2456/484 | 1.24 | (1.03–1.49) | 0.03 | 309/86 | 1.93 | (1.20–3.10) | 0.01 | 367/74 | 1.70 | (1.03–2.81) | 0.04 | 1535/281 | 1.06 | (0.83–1.35) | 0.64 | 0.09 | ||||
Breast cancer-specific mortality | |||||||||||||||||||||
Quartiles | 1 | 613/72 | ref. | 68/10 | ref. | 88/10 | ref. | 396/44 | ref. | ||||||||||||
2 | 614/55 | 0.71 | (0.50–1.02) | 79/12 | 1.11 | (0.46–2.69) | 103/14 | 1.20 | (0.52–2.76) | 370/24 | 0.56 | (0.34–0.92) | 0.48 | ||||||||
3 | 615/71 | 0.86 | (0.62–1.21) | 69/15 | 1.40 | (0.60–3.27) | 88/11 | 1.04 | (0.43–2.53) | 392/35 | 0.75 | (0.48–1.18) | |||||||||
4 | 614/78 | 0.97 | (0.70–1.36) | 93/18 | 1.33 | (0.58–3.09) | 88/15 | 1.66 | (0.73–3.77) | 377/40 | 0.80 | (0.51–1.26) | |||||||||
Continuousd | 2456/276 | 1.08 | (0.84–1.39) | 0.53 | 309/55 | 1.37 | (0.75–2.48) | 0.30 | 367/50 | 1.78 | (0.96–3.30) | 0.07 | 1535/143 | 0.92 | (0.66–1.29) | 0.63 | 0.09 | ||||
Recurrence-free survivale | |||||||||||||||||||||
Quartiles | 1 | 558/117 | ref. | 62/13 | ref. | 83/18 | ref. | 376/83 | ref. | ||||||||||||
2 | 566/116 | 0.92 | (0.71–1.20) | 75/20 | 1.32 | (0.64–2.73) | 99/20 | 0.86 | (0.45–1.65) | 353/71 | 0.86 | (0.63–1.19) | 0.05 | ||||||||
3 | 555/129 | 1.09 | (0.84–1.40) | 63/22 | 1.93 | (0.94–3.97) | 81/17 | 0.89 | (0.45–1.76) | 371/86 | 0.99 | (0.73–1.34) | |||||||||
4 | 560/145 | 1.13 | (0.88–1.46) | 88/37 | 2.35 | (1.20–4.58) | 84/23 | 1.31 | (0.70–2.45) | 352/83 | 0.93 | (0.67–1.27) | |||||||||
Continuousd | 2239/507 | 1.16 | (0.97–1.39) | 0.11 | 288/92 | 2.18 | (1.39–3.40) | < 0.001 | 347/78 | 1.50 | (0.92–2.45) | 0.11 | 1452/323 | 0.97 | (0.77–1.21) | 0.77 | 0.01 |