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Fig. 1 | Breast Cancer Research

Fig. 1

From: Lineage plasticity enables low-ER luminal tumors to evolve and gain basal-like traits

Fig. 1

Basal-like features of tumors expressing low ER. A Frequency of cases expressing low ER levels (< 1% ER-expressing nuclei) in newly diagnosed invasive breast carcinomas from the pathology database at Dartmouth-Hitchcock Medical Center (DHMC) from 2012–2020. B–E Breakdown of ER expression levels (B), ER intensity levels (C), PR expression (D), and Her2/neu amplification (E), in the 46 low-ER cases. F Patient demographics of the 46 low-ER cases in our cohort. G–J H&E staining of low-ER tumors showing solid tumor with pushing borders (G), pleomorphic, high-grade nuclei with admixed necrosis (H), prominent lymphoplasmacytic infiltrates (I), and conspicuous mitotic activity, including atypical mitoses (yellow arrows) (J)

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