Table 3 Calibration of original and modified PREDICT models in the METABRIC cohort for (a) ER-positive and (b) ER-negative patients
From: Evaluation and comparison of different breast cancer prognosis scores based on gene expression data
Model | 10-Year survival % | Difference | Difference optimism |
|---|---|---|---|
(a) | |||
METABRIC cohort | 74.0 | Reference | Reference |
PREDICT | 61.1 | − 13 | – |
PREDICT + Oncotype DX | 61.3 | − 12.8 | − 0.694 |
PREDICT + EndoPredict | 61.6 | − 12.5 | − 0.711 |
PREDICT + MammaPrint | 61.9 | − 12.2 | − 0.640 |
PREDICT + Prosigna | 61.2 | − 12.8 | − 0.706 |
(b) | |||
METABRIC cohort | 58.5 | Reference | Reference |
PREDICT | 49.7 | − 8.8 | – |
PREDICT + Oncotype DX | 50.5 | − 8 | − 0.307 |
PREDICT + EndoPredict | 52.9 | − 5.6 | − 0.403 |
PREDICT + MammaPrint | 48.3 | − 10.2 | − 0.150 |
PREDICT + Prosigna | 56.2 | − 2.3 | − 0.336 |