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Table 3 Risks of second primaries at specific sites

From: Risks of second non-breast primaries following breast cancer in women: a systematic review and meta-analysis

Cancer site

SIR (95% CI)—breast cancer diagnosed at any age

SIR (95% CI)—breast cancer diagnosed at under age 50

SIR (95% CI)—breast cancer diagnosed at age 50 or over

Number of studies in meta-analysis

Unstratified by age at BC dx

Aged under 50 at BC dx

Aged 50 or over at BC dx

Bladder1

1.15 (1.05–1.26)

1.32 (1.17–1.48)

1.08 (0.89–1.30)

8

4

4

Blood (leukaemia)2

1.30 (1.17–1.45)

1.91 (1.77–2.05)

1.34 (0.99–1.81)

8

4

4

Blood (myeloma)3

0.83 (0.68–1.02)

1.01 (0.53–1.94)

0.63 (0.48–0.82)

4

1

1

Blood (non-Hodgkin’s lymphoma)

1.04 (0.91–1.19)

1.17 (0.96–1.42)

0.93 (0.65–1.33)

7

2

2

Brain and central nervous system4

0.80 (0.71–0.91)

0.95 (0.81–1.11)

0.75 (0.69–0.81)

7

4

3

Cervix uteri5

0.88 (0.77–1.00)

0.65 (0.46–0.93)

0.57 (0.23–1.39)

10

2

2

Colorectum6

1.12 (0.99–1.27)

1.30 (0.91–1.86)

1.02 (0.87–1.19)

11

5

5

Corpus uteri7

1.84 (1.53–2.23)

1.40 (1.12–1.76)

1.75 (1.29–2.37)

16

5

5

Gallbladder8

1.13 (0.68–1.87)

0.49 (0.12–1.96)

0.86 (0.63–1.17)

7

1

1

Kidney9

1.43 (1.17–1.73)

1.29 (1.15–1.43)

1.35 (0.95–1.92)

11

4

4

Liver10

0.86 (0.60–1.24)

0.93 (0.71–1.21)

0.56 (0.33–0.96)

7

1

2

Lung11

1.25 (1.03–1.51)

1.65 (1.49–1.82)

0.81 (0.55–1.20)

12

3

3

Oesophagus

1.39 (1.26–1.55)

2.21 (1.89–2.60)

1.20 (1.06–1.37)

9

3

3

Ovary

1.53 (1.35–1.73)

2.24 (1.59–3.13)

1.04 (0.93–1.16)

16

6

6

Pancreas

1.09 (0.93–1.27)

1.35 (1.16–1.57)

0.92 (0.81–1.04)

11

3

4

Skin (melanoma)

1.34 (1.18–1.52)

1.34 (1.23–1.45)

1.25 (1.17–1.35)

7

3

3

Stomach

1.23 (1.12–1.36)

1.90 (1.75–2.06)

1.10 (0.91–1.34)

13

4

4

Thyroid

1.89 (1.49–2.38)

2.06 (1.83–2.31)

1.17 (0.90–1.52)

14

4

3

Vulva12

0.92 (0.63–1.35)

2

0

0

  1. 1Meta-analysis also includes data on cancer risks at the “urinary bladder”
  2. 2Meta-analysis includes data on combined lymphoid leukaemia and myeloid leukaemia risks
  3. 3Meta-analysis only includes data on “multiple myeloma(s)” risks
  4. 4Meta-analysis also includes data on cancer risks at the “brain and nervous system”, brain only, and nervous system only
  5. 5Meta-analysis also includes data on “cervical”, “cervix”, and “uterine cervix” cancer risks
  6. 6Meta-analysis includes data on combined colon and rectum cancer risks
  7. 7Meta-analysis also includes data on cancer risks at the “uterus” and “endometrium”
  8. 8Meta-analysis also includes data on cancer risks at the “gallbladder and bile ducts”, “gallbladder and common bile duct”, and “gallbladder/extrahepatic bile ducts”
  9. 9Meta-analysis also includes data on cancer risks at the “kidney and renal pelvis”
  10. 10Meta-analysis also includes data at the “liver and biliary tract” and “liver and bile ducts”
  11. 11Meta-analysis also includes data at the “lung and bronchus”
  12. 12Meta-analysis also includes data at the “vulva and vagina”