Cancer site | SIR (95% CI)—breast cancer diagnosed at any age | SIR (95% CI)—breast cancer diagnosed at under age 50 | SIR (95% CI)—breast cancer diagnosed at age 50 or over | Number of studies in meta-analysis | ||
---|---|---|---|---|---|---|
Unstratified by age at BC dx | Aged under 50 at BC dx | Aged 50 or over at BC dx | ||||
Bladder1 | 1.15 (1.05–1.26) | 1.32 (1.17–1.48) | 1.08 (0.89–1.30) | 8 | 4 | 4 |
Blood (leukaemia)2 | 1.30 (1.17–1.45) | 1.91 (1.77–2.05) | 1.34 (0.99–1.81) | 8 | 4 | 4 |
Blood (myeloma)3 | 0.83 (0.68–1.02) | 1.01 (0.53–1.94) | 0.63 (0.48–0.82) | 4 | 1 | 1 |
Blood (non-Hodgkin’s lymphoma) | 1.04 (0.91–1.19) | 1.17 (0.96–1.42) | 0.93 (0.65–1.33) | 7 | 2 | 2 |
Brain and central nervous system4 | 0.80 (0.71–0.91) | 0.95 (0.81–1.11) | 0.75 (0.69–0.81) | 7 | 4 | 3 |
Cervix uteri5 | 0.88 (0.77–1.00) | 0.65 (0.46–0.93) | 0.57 (0.23–1.39) | 10 | 2 | 2 |
Colorectum6 | 1.12 (0.99–1.27) | 1.30 (0.91–1.86) | 1.02 (0.87–1.19) | 11 | 5 | 5 |
Corpus uteri7 | 1.84 (1.53–2.23) | 1.40 (1.12–1.76) | 1.75 (1.29–2.37) | 16 | 5 | 5 |
Gallbladder8 | 1.13 (0.68–1.87) | 0.49 (0.12–1.96) | 0.86 (0.63–1.17) | 7 | 1 | 1 |
Kidney9 | 1.43 (1.17–1.73) | 1.29 (1.15–1.43) | 1.35 (0.95–1.92) | 11 | 4 | 4 |
Liver10 | 0.86 (0.60–1.24) | 0.93 (0.71–1.21) | 0.56 (0.33–0.96) | 7 | 1 | 2 |
Lung11 | 1.25 (1.03–1.51) | 1.65 (1.49–1.82) | 0.81 (0.55–1.20) | 12 | 3 | 3 |
Oesophagus | 1.39 (1.26–1.55) | 2.21 (1.89–2.60) | 1.20 (1.06–1.37) | 9 | 3 | 3 |
Ovary | 1.53 (1.35–1.73) | 2.24 (1.59–3.13) | 1.04 (0.93–1.16) | 16 | 6 | 6 |
Pancreas | 1.09 (0.93–1.27) | 1.35 (1.16–1.57) | 0.92 (0.81–1.04) | 11 | 3 | 4 |
Skin (melanoma) | 1.34 (1.18–1.52) | 1.34 (1.23–1.45) | 1.25 (1.17–1.35) | 7 | 3 | 3 |
Stomach | 1.23 (1.12–1.36) | 1.90 (1.75–2.06) | 1.10 (0.91–1.34) | 13 | 4 | 4 |
Thyroid | 1.89 (1.49–2.38) | 2.06 (1.83–2.31) | 1.17 (0.90–1.52) | 14 | 4 | 3 |
Vulva12 | 0.92 (0.63–1.35) | – | – | 2 | 0 | 0 |