Author and publication year | Total person years | FU1 time since BC2 dx3 strata | Age strata at BC dx | Specific SPC4s for which SIR5s reported | N6 first BC/N SPCs | SIR (95% CI7) for combined risk of non-breast SPCs |
---|---|---|---|---|---|---|
AIRTUM Working Group [1] | 1,274,882 | 0–1 m8, 2–11 m, 12–59 m, 60–119 m, >  = 120 m | 0–19, 20–29, 30–39, 40–49, 50–69, >  = 70 | Oral cavity, Pharynx, Larynx, Oesophagus, Stomach, Colon, Rectum, Liver, Gallbladder, Pancreas, Lung, Skin melanoma, Mesothelioma, Kaposi sarcoma, Soft tissue, Bone, Corpus Uteri, Cervix Uteri, Ovary, Kidney and renal pelvis, Bladder and urinary tract, Brain and central nervous system, Thyroid, Hodgkin’s lymphoma, Non-Hodgkin’s lymphomas, Multiple myeloma, Leukaemias (Lymphoid leukaemia, Myeloid leukaemia, Other leukaemias), Other sites | 215,809/10597 | 1.12 (1.10–1.14) |
Andersson [2] | 256,563 | 1–9 y9, 10–19 y, >  = 20 y |  < 50, 50–59, 60–69, 70–89 | Lip, Tongue, Salivary glands, Mouth, Pharynx, Oesophagus, Stomach, Small intestine, Colon, Rectum, Liver, Gallbladder, Pancreas, Nose (sinuses), Larynx, Lung, Pleura, Cervix Uteri, Corpus Uteri, Uterus (other), Ovary (uterine adnexa), Other female genital organs, Kidney, Bladder (and other unspecified related sites), Melanoma of skin, Eye, Brain and nervous system, Thyroid, Bone, Soft tissues, Non-Hodgkin’s Lymphoma, Hodgkin’s disease, Multiple myeloma, Acute leukaemia, Other leukaemia | 31,818/1993 | 1.04 (0.99–1.08) |
Brenner [3] | 43,642.25 | Unreported |  < 50, >  = 50 | Stomach, Colon, Rectum, Gallbladder and bile ducts, Pancreas, Corpus Uteri, Cervix Uteri, Ovaries, Urinary bladder, Kidneys, Lymphomas and leukaemias | 9678/206 | 0.84 (0.73–0.96) |
Brown [4] | 2,990,587 | 1–9 y, 10–19 y, 20–29 y, >  = 30 y |  < 40, 40–49, 50–64, > 64 | Salivary gland, Oesophagus, Lung, Pleura, Thyroid, Bone, Connective tissue, Uterine corpus, Lip, Tongue, Mouth, Pharynx, Stomach, Small intestine, Colon, Rectum/anus, Liver, Pancreas, Gallbladder, Nose/nasal cavity, Larynx, Cervix, Ovary, Kidney, Bladder, Malignant Melanoma, Eye, Brain and central nervous system | 376,825/23158 | 1.15 (1.14–1.17) |
Chen (Germany) [5] | Unreported | Unreported | Unreported | Unreported | 234,863 (male and female combined)/3676 | 1.15 (1.13–1.17). 1.15 is the midpoint of the reported 95% CI—it was taken as an approximation for the SIR due to early rounding in the study |
Diab [6] | Unreported | Unreported |  < 50, >  = 50 | Oral cavity and pharynx, Digestive system, Colon, rectum, and anus, Pancreas, Peritoneum, omentum and mesentery, Respiratory system, Bones and joints, Soft tissue including heart, Skin excluding basal and squamous, Breast, Female genital system, Corpus and uterus (not otherwise specified), Ovary, Urinary system, Brain and other nervous system, Endocrine system, Lymphoma, Leukaemia | 514,479/45509 | 1.03 (1.02–1.04) |
Evans [7] | 832,958.1 | Unreported |  < 50, >  = 50 | Tongue, Mouth, Oesophagus, Stomach, Colon, Rectum, Liver, Gallbladder, Pancreas, Larynx, Lung and bronchus, Bone, Connective tissue, Skin melanoma, Cervix Uteri, Corpus Uteri, Ovary, Bladder, Kidney, Brain and nervous system, Thyroid, Non-Hodgkin’s Lymphoma, Multiple myeloma, Lymphoid Leukaemia, Myeloid Leukaemia | 145,677/4470 | 0.89 (0.86–0.92) |
Gulhan [18] | 16,377 | Unreported | Unreported | Endometrial, Ovary, Cervical | 6356/88 | 1.76 (1.43–2.17) |
Harvey [8] | 271,524 |  < 1 y, 1–4 y, 5–9 y, >  = 10 y |  < 45, 45–54, >  = 55 | Lip, Tongue, Salivary gland, Gum and other mouth, Pharynx, Oesophagus, Stomach, Colon, Rectum, Liver (biliary), Pancreas, Nasal cavities and sinuses, Larynx, Trachea, bronchus, and lung, Cervix uteri, Corpus uteri, Uterus (not otherwise specified), Ovary and fallopian tubes, Kidney and renal pelvis and ureter, Bladder and other urinary, Skin (melanoma), Eye, Brain and central nervous system, Thyroid gland, Bone, Connective tissue, Non-Hodgkin’s lymphoma, Hodgkin’s disease, Multiple myeloma, Leukaemias, Chronic lymphocytic leukaemia, Acute nonlymphocytic leukaemia | 41,109/2057 | 1.15 (1.10–1.20) |
Hung [19] | 527,009 |  < 1 y, 1–4 y, >  = 5 y | 20–29, 30–39, 40–49, 50–59, 60–69, 70–79, >  = 80 | Head and neck, Oesophagus, Stomach, Colon and rectum and anus, Liver and biliary tract, Liver, Lung and mediastinum, Bone and soft tissue, Skin, Cervix, Uterus, Ovary, Bladder, Kidney, Thyroid, Hematologic malignancies, All others | 100,915/3,080 | 1.50 (1.44–1.55) |
Jégu [9] | 351,434 | Unreported | Unreported | Corpus Uteri | Unreported/2476 | 1.31 (1.26–1.36) |
Jung [20] | 13,433.5 | Unreported | 30–39, 40–49, 50–59, 60–69, >  = 70 | Oesophagus, Stomach, Colon and rectum, Anus, Liver, Gallbladder and common bile duct, Lung, Cervix, Endometrium, Ovary, Kidney, Bladder, Thyroid, Hodgkin’s lymphoma, Non-Hodgkin’s lymphoma, Acute myeloid leukaemia, Skin, Muscle | 3344/93 | 1.56 (1.27–1.91) |
Lee [21] | 290,966 |  <  = 5 y, 6–10 y, > 10 y |  < 50, >  = 50 | Bone, Corpus uteri, Ovary, Non-melanoma skin, Thyroid, Head and neck, Nasopharynx and nasal cavity, Oesophagus, Stomach, Small intestine, Colon and rectum, Liver, Biliary system, Pancreas, Lung, Thymus, Sarcoma, Cervix uteri, Urinary bladder, Kidney and other urinary organs, Brain, Leukaemia or lymphoma, Others | 53,783/1085 | 1.09 (1.03–1.16) |
Levi [10] | 61,834 |  < 5 y, >  = 5 y | Unreported | Mouth and pharynx, Oesophagus, Stomach, Colorectum, Gallbladder, Pancreas, Lung, Soft tissue, Skin melanoma, Cervix Uteri, Corpus Uteri, Ovary, Other female genital organs, Bladder, Kidney, Thyroid, Non-Hodgkin’s lymphomas, Multiple myelomas, Leukaemias, Other and unknown sites | 9729/443 | 1.14 (1.04–1.25) |
Mellemkjaer [33] | 3,784,660 |  < 1 y, 1–9 y, >  = 10y |  <  = 45, 46–55, >  = 56 | Oral cavity and pharynx, Oesophagus, Stomach, Small intestine, Colorectal, Liver, Pancreas, Larynx, Lung, Bone, Soft tissue sarcoma (of thorax and upper lim inc. shoulder), Melanoma, Non-melanoma skin cancer, Corpus Uteri, Ovary, Bladder, Kidney, Brain and nervous system, Thyroid gland, Non-Hodgkin’s lymphoma, Leukaemia, Myeloid leukaemia | 525,527/31399 | 1.25 (1.24–1.26) |
Molina-Montes [11] | 37,605 |  < 5 y, >  = 5 y |  < 50, >  = 50 | Endometrium, Colon and rectum, Stomach, Ovary, Thyroid gland, Non-melanoma skin, Kidney, Bladder, Hematologic malignancies (lymphoid leukaemia, myeloid leukaemia, and multiple myeloma) | 5897/314 | 1.39 (1.24–1.55) |
Murakami [22] | 53,738 |  < 1 y, 1–4 y, 5–9 y, >  = 10 y |  < 45, 45–54, >  = 55 | Buccal cavity, Stomach, Oesophagus, Colon, Rectum, Liver, Pancreas, Lung, Cervix Uteri, Corpus Uteri, Ovary, Urinary bladder, Thyroid gland, Leukaemia | 9503/254 | 1.34 (1.18–1.52) |
Odani [23] | 266,685 | 3 m–1 y, 1–5 y, 5–10 y | Unreported | Oral cavity/pharynx, Stomach, Colorectum, Liver, Gallbladder, Pancreas, Lung, Uterus, Ovary, Kidney/urinary tract/bladder, Thyroid, Blood | 47,622/1843 | 1.84 (1.76–1.92) |
Ricceri [12] | 56,496 | Unreported | Unreported | Colorectum, Lung, Pancreas, Melanoma, Endometrium, Ovary, Kidney, Thyroid gland, Lymphomas | 10,045/352 | 1.30 (1.18–1.42) |
Rubino [13] | 33,044 | 1–10 y, >  = 10 y |  < 50, >  = 50 | Oral cavity, Oesophagus, Stomach, Colon and rectum, Liver and gallbladder, Pancreas, Larynx, Lung and bronchus, Uterus, Ovaries, Bladder, Kidney, Melanoma, Nervous system, Thyroid, Other endocrine, Bone, Soft tissue, Undefined sites, Myeloma, Lymphoma, Leukaemia | 4416/193 | 1.40 (1.21–1.62) |
Schaapveld [14] | 362,470 | Not reported in a fashion that allows accurate extraction of age-stratified SIRs and corresponding 95% standard errors |  < 50, >  = 50 | Head and neck, Thyroid, Oesophagus, Stomach, Pancreas, Gallbladder/extrahepatic bile ducts, Colon, Rectum and Anus, Lung, Soft tissue sarcomas, Melanoma of skin, Ovary, Cervix, Uterus, Vulva, Kidney, Bladder, Brain, Acute myeloid leukaemia, Other Leukaemia, Non-Hodgkin’s lymphoma, Multiple myeloma | 58,068/2578 | 1.22 (1.17–1.27) |
Schottenfeld [15] | Unreported | Unreported | Unreported | Ovary, Corpus Uteri, Cervix Uteri, Vulva and vagina, Buccal cavity and Pharynx, Oesophagus, Stomach, Colon, Rectum, Pancreas, Liver and bile ducts, Larynx, Lung, Kidney, Bladder, Lymphoma and leukaemia, Salivary glands, Thyroid, Soft-part sarcomas, Bone sarcomas | 9792/231 | 1.01 (0.9–1.1) |
Silverman [24] | 363,333 | Unreported |  < 50, >  = 50 | Colorectum, Uterus, Lung, Ovary, Non-Hodgkin's Lymphoma, Brain, Melanoma (invasive), Thyroid, Leukaemia, Uterine Cervix | 43,794/3866 | 1.26 (1.23–1.30) |
Tabuchi [25] | 197,571 |  < 1 y, 1–5 y, 5–10 y | Unreported | Mouth/pharynx, Stomach, Oesophagus, Colorectal, Liver, Gallbladder, Pancreas, Lung, Uterus, Ovary, Thyroid, Kidney/urinary tract/bladder, Blood | Unreported/1007 | 1.48 (1.39–1.57) |
Trama [16] | 102,629 |  < 5 y, 5–10 y, 10–15 y, 15–20 y, 20–25 y, > 25 y | Unreported | Soft tissue sarcomas, Colorectal, Stomach, Pancreatic, Liver, Bladder, Kidney, Cervical, Ovarian, Corpus Uteri, Central nervous system, Germ cell | 11,328/299 | 1.13 (1.0–1.3) |
Tsukuma [26] | Unreported |  < 1 y, 1–4 y, 5–9 y | Unreported | Stomach, Colon, Lung, Thyroid | Unreported/226 | 1.42 (1.25–1.62) |
Utada [27] | Unreported | Not reported in a fashion that allows accurate extraction of age-stratified SIRs and corresponding 95% standard errors | Unreported | Lung, Uterus, Ovary, Thyroid | Unreported/727 | 1.16 (1.08–1.25) |
Zheng [17] | Unreported | Unreported | Unreported | Upper aerodigestive tract, Oesophagus, Stomach, Small intestine, Colorectum, Anus, Liver, Nose, Pancreas, Lung, Cervix, Endometrium, Uterus, Ovary, Other female genitals, Kidney, Bladder, Melanoma, Skin (squamous cell carcinoma), Eye, Nervous system, Thyroid gland, Endocrine gland, Bone, Connective Tissue, Non-Hodgkin’s lymphoma, Hodgkin’s lymphoma, Myeloma, Leukaemia, Cancer of unknown primary, Colon, Rectum | 87,752/6299 | 1.43 (1.40–1.47) |