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Table 2 Further study characteristics

From: Risks of second non-breast primaries following breast cancer in women: a systematic review and meta-analysis

Author and publication year

Total person years

FU1 time since BC2 dx3 strata

Age strata at BC dx

Specific SPC4s for which SIR5s reported

N6 first BC/N SPCs

SIR (95% CI7) for combined risk of non-breast SPCs

AIRTUM Working Group [1]

1,274,882

0–1 m8, 2–11 m, 12–59 m, 60–119 m, >  = 120 m

0–19, 20–29, 30–39, 40–49, 50–69, >  = 70

Oral cavity, Pharynx, Larynx, Oesophagus, Stomach, Colon, Rectum, Liver, Gallbladder, Pancreas, Lung, Skin melanoma, Mesothelioma, Kaposi sarcoma, Soft tissue, Bone, Corpus Uteri, Cervix Uteri, Ovary, Kidney and renal pelvis, Bladder and urinary tract, Brain and central nervous system, Thyroid, Hodgkin’s lymphoma, Non-Hodgkin’s lymphomas, Multiple myeloma, Leukaemias (Lymphoid leukaemia, Myeloid leukaemia, Other leukaemias), Other sites

215,809/10597

1.12 (1.10–1.14)

Andersson [2]

256,563

1–9 y9, 10–19 y, >  = 20 y

 < 50, 50–59, 60–69, 70–89

Lip, Tongue, Salivary glands, Mouth, Pharynx, Oesophagus, Stomach, Small intestine, Colon, Rectum, Liver, Gallbladder, Pancreas, Nose (sinuses), Larynx, Lung, Pleura, Cervix Uteri, Corpus Uteri, Uterus (other), Ovary (uterine adnexa), Other female genital organs, Kidney, Bladder (and other unspecified related sites), Melanoma of skin, Eye, Brain and nervous system, Thyroid, Bone, Soft tissues, Non-Hodgkin’s Lymphoma, Hodgkin’s disease, Multiple myeloma, Acute leukaemia, Other leukaemia

31,818/1993

1.04 (0.99–1.08)

Brenner [3]

43,642.25

Unreported

 < 50, >  = 50

Stomach, Colon, Rectum, Gallbladder and bile ducts, Pancreas, Corpus Uteri, Cervix Uteri, Ovaries, Urinary bladder, Kidneys, Lymphomas and leukaemias

9678/206

0.84 (0.73–0.96)

Brown [4]

2,990,587

1–9 y, 10–19 y, 20–29 y, >  = 30 y

 < 40, 40–49, 50–64, > 64

Salivary gland, Oesophagus, Lung, Pleura, Thyroid, Bone, Connective tissue, Uterine corpus, Lip, Tongue, Mouth, Pharynx, Stomach, Small intestine, Colon, Rectum/anus, Liver, Pancreas, Gallbladder, Nose/nasal cavity, Larynx, Cervix, Ovary, Kidney, Bladder, Malignant Melanoma, Eye, Brain and central nervous system

376,825/23158

1.15 (1.14–1.17)

Chen (Germany) [5]

Unreported

Unreported

Unreported

Unreported

234,863 (male and female combined)/3676

1.15 (1.13–1.17). 1.15 is the midpoint of the reported 95% CI—it was taken as an approximation for the SIR due to early rounding in the study

Diab [6]

Unreported

Unreported

 < 50, >  = 50

Oral cavity and pharynx, Digestive system, Colon, rectum, and anus, Pancreas, Peritoneum, omentum and mesentery, Respiratory system, Bones and joints, Soft tissue including heart, Skin excluding basal and squamous, Breast, Female genital system, Corpus and uterus (not otherwise specified), Ovary, Urinary system, Brain and other nervous system, Endocrine system, Lymphoma, Leukaemia

514,479/45509

1.03 (1.02–1.04)

Evans [7]

832,958.1

Unreported

 < 50, >  = 50

Tongue, Mouth, Oesophagus, Stomach, Colon, Rectum, Liver, Gallbladder, Pancreas, Larynx, Lung and bronchus, Bone, Connective tissue, Skin melanoma, Cervix Uteri, Corpus Uteri, Ovary, Bladder, Kidney, Brain and nervous system, Thyroid, Non-Hodgkin’s Lymphoma, Multiple myeloma, Lymphoid Leukaemia, Myeloid Leukaemia

145,677/4470

0.89 (0.86–0.92)

Gulhan [18]

16,377

Unreported

Unreported

Endometrial, Ovary, Cervical

6356/88

1.76 (1.43–2.17)

Harvey [8]

271,524

 < 1 y, 1–4 y, 5–9 y, >  = 10 y

 < 45, 45–54, >  = 55

Lip, Tongue, Salivary gland, Gum and other mouth, Pharynx, Oesophagus, Stomach, Colon, Rectum, Liver (biliary), Pancreas, Nasal cavities and sinuses, Larynx, Trachea, bronchus, and lung, Cervix uteri, Corpus uteri, Uterus (not otherwise specified), Ovary and fallopian tubes, Kidney and renal pelvis and ureter, Bladder and other urinary, Skin (melanoma), Eye, Brain and central nervous system, Thyroid gland, Bone, Connective tissue, Non-Hodgkin’s lymphoma, Hodgkin’s disease, Multiple myeloma, Leukaemias, Chronic lymphocytic leukaemia, Acute nonlymphocytic leukaemia

41,109/2057

1.15 (1.10–1.20)

Hung [19]

527,009

 < 1 y, 1–4 y, >  = 5 y

20–29, 30–39, 40–49, 50–59, 60–69, 70–79, >  = 80

Head and neck, Oesophagus, Stomach, Colon and rectum and anus, Liver and biliary tract, Liver, Lung and mediastinum, Bone and soft tissue, Skin, Cervix, Uterus, Ovary, Bladder, Kidney, Thyroid, Hematologic malignancies, All others

100,915/3,080

1.50 (1.44–1.55)

Jégu [9]

351,434

Unreported

Unreported

Corpus Uteri

Unreported/2476

1.31 (1.26–1.36)

Jung [20]

13,433.5

Unreported

30–39, 40–49, 50–59, 60–69, >  = 70

Oesophagus, Stomach, Colon and rectum, Anus, Liver, Gallbladder and common bile duct, Lung, Cervix, Endometrium, Ovary, Kidney, Bladder, Thyroid, Hodgkin’s lymphoma, Non-Hodgkin’s lymphoma, Acute myeloid leukaemia, Skin, Muscle

3344/93

1.56 (1.27–1.91)

Lee [21]

290,966

 <  = 5 y, 6–10 y, > 10 y

 < 50, >  = 50

Bone, Corpus uteri, Ovary, Non-melanoma skin, Thyroid, Head and neck, Nasopharynx and nasal cavity, Oesophagus, Stomach, Small intestine, Colon and rectum, Liver, Biliary system, Pancreas, Lung, Thymus, Sarcoma, Cervix uteri, Urinary bladder, Kidney and other urinary organs, Brain, Leukaemia or lymphoma, Others

53,783/1085

1.09 (1.03–1.16)

Levi [10]

61,834

 < 5 y, >  = 5 y

Unreported

Mouth and pharynx, Oesophagus, Stomach, Colorectum, Gallbladder, Pancreas, Lung, Soft tissue, Skin melanoma, Cervix Uteri, Corpus Uteri, Ovary, Other female genital organs, Bladder, Kidney, Thyroid, Non-Hodgkin’s lymphomas, Multiple myelomas, Leukaemias, Other and unknown sites

9729/443

1.14 (1.04–1.25)

Mellemkjaer [33]

3,784,660

 < 1 y, 1–9 y, >  = 10y

 <  = 45, 46–55, >  = 56

Oral cavity and pharynx, Oesophagus, Stomach, Small intestine, Colorectal, Liver, Pancreas, Larynx, Lung, Bone, Soft tissue sarcoma (of thorax and upper lim inc. shoulder), Melanoma, Non-melanoma skin cancer, Corpus Uteri, Ovary, Bladder, Kidney, Brain and nervous system, Thyroid gland, Non-Hodgkin’s lymphoma, Leukaemia, Myeloid leukaemia

525,527/31399

1.25 (1.24–1.26)

Molina-Montes [11]

37,605

 < 5 y, >  = 5 y

 < 50, >  = 50

Endometrium, Colon and rectum, Stomach, Ovary, Thyroid gland, Non-melanoma skin, Kidney, Bladder, Hematologic malignancies (lymphoid leukaemia, myeloid leukaemia, and multiple myeloma)

5897/314

1.39 (1.24–1.55)

Murakami [22]

53,738

 < 1 y, 1–4 y, 5–9 y, >  = 10 y

 < 45, 45–54, >  = 55

Buccal cavity, Stomach, Oesophagus, Colon, Rectum, Liver, Pancreas, Lung, Cervix Uteri, Corpus Uteri, Ovary, Urinary bladder, Thyroid gland, Leukaemia

9503/254

1.34 (1.18–1.52)

Odani [23]

266,685

3 m–1 y, 1–5 y, 5–10 y

Unreported

Oral cavity/pharynx, Stomach, Colorectum, Liver, Gallbladder, Pancreas, Lung, Uterus, Ovary, Kidney/urinary tract/bladder, Thyroid, Blood

47,622/1843

1.84 (1.76–1.92)

Ricceri [12]

56,496

Unreported

Unreported

Colorectum, Lung, Pancreas, Melanoma, Endometrium, Ovary, Kidney, Thyroid gland, Lymphomas

10,045/352

1.30 (1.18–1.42)

Rubino [13]

33,044

1–10 y, >  = 10 y

 < 50, >  = 50

Oral cavity, Oesophagus, Stomach, Colon and rectum, Liver and gallbladder, Pancreas, Larynx, Lung and bronchus, Uterus, Ovaries, Bladder, Kidney, Melanoma, Nervous system, Thyroid, Other endocrine, Bone, Soft tissue, Undefined sites, Myeloma, Lymphoma, Leukaemia

4416/193

1.40 (1.21–1.62)

Schaapveld [14]

362,470

Not reported in a fashion that allows accurate extraction of age-stratified SIRs and corresponding 95% standard errors

 < 50, >  = 50

Head and neck, Thyroid, Oesophagus, Stomach, Pancreas, Gallbladder/extrahepatic bile ducts, Colon, Rectum and Anus, Lung, Soft tissue sarcomas, Melanoma of skin, Ovary, Cervix, Uterus, Vulva, Kidney, Bladder, Brain, Acute myeloid leukaemia, Other Leukaemia, Non-Hodgkin’s lymphoma, Multiple myeloma

58,068/2578

1.22 (1.17–1.27)

Schottenfeld [15]

Unreported

Unreported

Unreported

Ovary, Corpus Uteri, Cervix Uteri, Vulva and vagina, Buccal cavity and Pharynx, Oesophagus, Stomach, Colon, Rectum, Pancreas, Liver and bile ducts, Larynx, Lung, Kidney, Bladder, Lymphoma and leukaemia, Salivary glands, Thyroid, Soft-part sarcomas, Bone sarcomas

9792/231

1.01 (0.9–1.1)

Silverman [24]

363,333

Unreported

 < 50, >  = 50

Colorectum, Uterus, Lung, Ovary, Non-Hodgkin's Lymphoma, Brain, Melanoma (invasive), Thyroid, Leukaemia, Uterine Cervix

43,794/3866

1.26 (1.23–1.30)

Tabuchi [25]

197,571

 < 1 y, 1–5 y, 5–10 y

Unreported

Mouth/pharynx, Stomach, Oesophagus, Colorectal, Liver, Gallbladder, Pancreas, Lung, Uterus, Ovary, Thyroid, Kidney/urinary tract/bladder, Blood

Unreported/1007

1.48 (1.39–1.57)

Trama [16]

102,629

 < 5 y, 5–10 y, 10–15 y, 15–20 y, 20–25 y, > 25 y

Unreported

Soft tissue sarcomas, Colorectal, Stomach, Pancreatic, Liver, Bladder, Kidney, Cervical, Ovarian, Corpus Uteri, Central nervous system, Germ cell

11,328/299

1.13 (1.0–1.3)

Tsukuma [26]

Unreported

 < 1 y, 1–4 y, 5–9 y

Unreported

Stomach, Colon, Lung, Thyroid

Unreported/226

1.42 (1.25–1.62)

Utada [27]

Unreported

Not reported in a fashion that allows accurate extraction of age-stratified SIRs and corresponding 95% standard errors

Unreported

Lung, Uterus, Ovary, Thyroid

Unreported/727

1.16 (1.08–1.25)

Zheng [17]

Unreported

Unreported

Unreported

Upper aerodigestive tract, Oesophagus, Stomach, Small intestine, Colorectum, Anus, Liver, Nose, Pancreas, Lung, Cervix, Endometrium, Uterus, Ovary, Other female genitals, Kidney, Bladder, Melanoma, Skin (squamous cell carcinoma), Eye, Nervous system, Thyroid gland, Endocrine gland, Bone, Connective Tissue, Non-Hodgkin’s lymphoma, Hodgkin’s lymphoma, Myeloma, Leukaemia, Cancer of unknown primary, Colon, Rectum

87,752/6299

1.43 (1.40–1.47)

  1. 1Follow-up
  2. 2Diagnosis/Diagnoses/Diagnosed
  3. 3Breast Cancer
  4. 4Second Primary Cancer
  5. 5Standardized Incidence Ratio
  6. 6Number (of)
  7. 7Confidence Interval
  8. 8Month/Months
  9. 9Year/Years