Table 3 Phe-MR analyses for causal associations of HDL-C and acetate with the risk of multiple non-breast cancer diseases

HDL-C

411.4

Coronary atherosclerosis

Circulatory system

1.30 (1.25–1.36)

4.13 × 10^–11

1.23 (1.18–1.29)

3.96 × 10^–6

1.32 (1.29–1.35)

2.45 × 10^–33

442.11

Abdominal aortic aneurysm

Circulatory system

1.53 (1.40–1.67)

1.04 × 10^–9

1.49 (1.29–1.73)

7.56 × 10^–6

1.54 (1.42–1.67)

1.01 × 10^–9

444

Arterial embolism and thrombosis

Circulatory system

1.91 (1.72–2.12)

7.01 × 10^–10

2.24 (1.86–2.69)

1.12 × 10^–5

1.92 (1.74–2.12)

2.32 × 10^–11

1001

Foreign body injury

Injuries and poisonings

1.72 (1.58–1.87)

1.79 × 10^–10

1.94 (1.65–2.27)

3.01 × 10^–5

1.73 (1.59–1.88)

2.10 × 10^–10

Acetate

318

Tobacco use disorder

Mental disorders

2.87 (2.39–3.45)

6.87 × 10^–9

3.11 (2.37–4.07)

2.84 × 10^–5

2.95 (2.44–3.56)

1.21 × 10^–8