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Table 2 MR analyses for blood metabolites having etiologic associations with breast cancer risks

From: Association between human blood metabolome and the risk of breast cancer

Metabolite

IVW

Weighted median

MR-RAPS

MR-Egger Intercept

OR (95% CI)

P value

OR (95% CI)

P value

OR (95% CI)

P value

P value

HDL-C

1.09 (1.06–1.12)

9.67 × 10–10

1.09 (1.05–1.13)

2.07 × 10–5

1.09 (1.07–1.11)

1.85 × 10–15

0.16

Acetate

1.24 (1.13–1.37)

1.35 × 10–5

1.33 (1.15–1.52)

7.54 × 10–5

1.25 (1.13–1.38)

8.89 × 10–15

0.13

  1. IVW inverse-variance weighted, MR-RAPS Mendelian randomization robust adjusted profile score
  2. Odds ratios (ORs) with their 95% confidence intervals (CIs) represent the association estimates with the risk of breast cancer of per 1-SD increase in HDL-C and acetate levels, respectively
  3. Significant threshold in stage 1 was set at P < 0.05/112 = 4.46 × 10–4 (Bonferroni-corrected significance threshold calculated as 0.05 divided by 112 [for 112 blood metabolites])
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Breast Cancer Research

ISSN: 1465-542X

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