Table 1 Characteristics of GWASs on the metabolome used for genetic instrument selection
From: Association between human blood metabolome and the risk of breast cancer
Reference | Cohort(s) | Cohort description | Sample size | Number of metabolic traits | Biomarker assay | Blood fraction tested | Ethnicity | Year |
|---|---|---|---|---|---|---|---|---|
Shin et al | KORA; TwinsUK | Population-based cohort; Population-based twin study | 7,824 | 453 | Metabolon | Serum; plasma | German; British | 2014 |
Kettunen et al | EGCUT; ERF; FTC; FR97; COROGENE; GenMets; HBCS; KORA; LLS; NTR; NFBC 1966; PredictCVD; PROTE; YFS | Population-based cohort; Family-based; Population-based twin study; Population-based cohort; Case–control study (only controls used); Case–control study; Birth cohort; Population-based cohort; Family-based; Population-based twin study; Birth cohort; Cohort study; Population-based; Follow up study in children | 24,925 | 123 | NMR | Serum; plasma | Estonian; Dutch; Finnish; Finnish; Finnish; Finnish; Finnish; German; Dutch; Dutch; Finnish; Finnish; Estonian; Finnish | 2016 |
Borges et al | UK Biobank | Population-based cohort | 115,078 | 249 | Nightingale Health (NMR) | Blood | British | 2020 |