Table 1 Clinicopathological characteristics, intrinsic molecular subtypes of PAM50, and PAM50-based ROR of the 59 NST and paired metaplastic components from 27 patients with MpBC
Case | MpBC subtype | Histologic components | Dissectible components | PAM50 subtype | ROR | Age | TNM stage | Stage | ER/PR/HER2 | SBR grade |
|---|---|---|---|---|---|---|---|---|---|---|
BT5 | SPC | SPS/NST | SPS/NST | BL/BL | 75/62 | 73 | T3N0M0 | IIB | (−/ −/ −) | (III, III) |
BT34 | SPC | SPS/NST | SPS/NST | BL/BL | 80/80 | 63 | T2N0M0 | IIA | (−/ −/− in SPS; 5%/ −/− in NST) | (III, III) |
BT42 | SPC | SPS/SQC/NST | SPS/NST | BL/BL | 52/50 | 53 | T2N0M0 | IIA | (−/ −/ −) | (III, III) |
BT46 | SPC | SPS/NST | SPS/NST | BL/BL | 55/62 | 39 | T1N0M0 | IA | (−/ −/ −) | (III, III) |
BT61 | SPC | SPS/NST | SPS/ NST | BL/HER2e | 64/ 85 | 69 | T2N0M0 | IIA | (−/ −/− in SPS; −/ −/ + in NST) | (III, III) |
BT65 | SPC | SPS/NST | SPS/NST | BL/BL | 72/ 56 | 46 | T1N0M0 | IA | (−/ −/ −) | (III, III) |
BT91 | SPC | SPS/SQC/NST | SPS/NST | BL/BL | 74/62 | 91 | T4N1M0 | IIIB | (−/ −/− in SPS; 20%/ −/− in NST) | (III, III) |
BT95 | MMC | SPS/MAT/NST | SPS/MAT/NST | BL/BL/BL | 76/68/63 | 46 | T3N1M0 | IIIA | (−/ −/ −) | (III, II, III) |
BT15 | MMC | SPS/ RHA/ MAT/ NST | SPS/RHA/NST | BL/BL/BL | 62/70/60 | 47 | T3N0M0 | IIB | (−/ −/ −) | (III, III, III) |
BT118 | MMC | SPS/OGS/MAT/ NST | SPS/OGS/MAT/NST | BL/BL/BL/BL | 77/67/49/62 | 74 | T2N0M0 | IIA | (−/ −/ −) | (III, III, III, III) |
BT122 | SPC | SPS/NST | SPS/NST | BL/BL | 70/59 | 54 | T3N1M0 | IIIA | (−/ −/ −) | (III, III) |
BT127 | SPC | SPS/SQC/NST | SPS/SQC/NST | BL/BL/ BL | 86/56/71 | 60 | T2N1M0 | IIB | (−/ −/ −) | (III, III, III) |
BT3 | SCC | SQC/NST | SQC/NST | BL/LA | 51/51 | 72 | T4N3M0 | IIIC | (−/ −/− in SCC; 70%/ −/− in NST) | (III, II) |
BT83 | SCC | SQC/NST | SQC/NST | BL/HER2e | 56/70 | 48 | T4N3M0 | IIIC | (−/ −/− in SCC; 60%/ −/ −* in NST) | (III, II) |
BT131 | SCC | SQC/NST | SQC/ NST | BL/HER2e | 56/90 | 49 | T2N0M0 | IIA | −/ −/− in SCC; −/ −/ + in NST | (III, III) |
BT23 | MHM | RHA/NST | RHA/NST | BL/BL | 87/59 | 51 | T3N0M0 | IIB | −/ −/ − | (III, III) |
BT57 | MHM | RHA/NST | RHA/NST | BL/BL | 62/54 | 72 | T2N1M0 | IIB | −/ −/ − | (III, III) |
BT69 | MHM | RHA/NST | RHA/NST | BL/HER2e | 76/68 | 81 | T3N1M0 | IIIA | −/ −/− in RHA; −/ −/ + in NST | (III, III) |
BT137 | MHM | RHA/NST | RHA/NST | BL/LA | 79/39 | 48 | T1N0M0 | IA | −/ −/− in RHA; 10%/ 5%/− in NST | (III, III) |
BT79 | MHM | RHA/SQC/NST | RHA/NST | BL/BL | 79/67 | 44 | T3N1M0 | IIIA | −/ −/ − | (III, III) |
BT6 | MHM | MAT/NST | MAT/NST | BL/BL | 58/77 | 43 | T3N2M0 | IIIB | −/ −/ − | (II, III) |
BT44 | MHM | MAT/SQC/NST | MAT/NST | BL/BL | 45/62 | 56 | T3N0M0 | IIB | −/ −/ − | (II, II) |
BT64 | MHM | MAT/NST | MAT/NST | BL/BL | 50/58 | 60 | T2N0M0 | IIA | −/ −/ − | (III, III) |
BT71 | MHM | MAT/NST | MAT/NST | BL/BL | 50/57 | 54 | T2N0M0 | IIA | −/ −/ − | (III, III) |
BT85 | MHM | MAT/NST | MAT/NST | BL/BL | 44/65 | 72 | T1N0M0 | IA | −/ −/ − | (II, III) |
BT100 | MHM | MAT/NST | MAT/NST | BL/BL | 69/75 | 40 | T3N1M0 | IIIA | −/ −/ − | (III, III) |
BT130 | MHM | MAT/NST | MAT/NST | BL/BL | 59/33 | 43 | T3N1M0 | IIIA | −/ −/ − | (II, III) |