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Fig. 4 | Breast Cancer Research

Fig. 4

From: Transcriptomic alterations underlying metaplasia into specific metaplastic components in metaplastic breast carcinoma

Fig. 4

Differences in differentially expressed genes between the NST components and paired metaplastic components. A Heat map of differences in differentially expressed genes between these components (paired t test, p < 0.01) clustered into four groups. The top panel presents genes significantly downregulated (blue) or significantly upregulated (red) in corresponding cell types compared with the corresponding genes in the NST components. B Immunohistochemical validation of FBN, SLC2A1, EPAS1, and IL1RN, representative differentially expressed genes in the SPS, MAT, RHA, and SQC components, respectively. C Heat map showing gene–function associations. The order of the genes was identical to that in A. The top panel presents genes significantly downregulated (blue) or significantly upregulated (red) in corresponding cell types compared with the corresponding genes in the NST components

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