Table 2 Metabolites associated with breast cancer at FDR < 0.20
From: A prospective case–cohort analysis of plasma metabolites and breast cancer risk
Metabolite | Metabolite class | RR (95% CI)a | p | FDR |
|---|---|---|---|---|
PC (18:2/18:2) | Lipid | 0.85 (0.80, 0.92) | 1.19 × 10−5 | 6.87 × 10−3 |
PC (18:2/18:3)* | Lipid | 0.85 (0.79, 0.91) | 1.58 × 10−5 | 6.87 × 10−3 |
Azelate (C9-DC) | Lipid | 0.87 (0.81, 0.93) | 1.17 × 10−4 | 3.38 × 10−2 |
PC (O-16:0/18:2)* | Lipid | 0.87 (0.82, 0.94) | 1.93 × 10−4 | 3.42 × 10−2 |
LysoPE (18:1) | Lipid | 0.87 (0.81, 0.94) | 2.23 × 10−4 | 3.42 × 10−2 |
2-Hydroxydecanoate | Lipid | 0.87 (0.81, 0.94) | 2.37 × 10−4 | 3.42 × 10−2 |
LysoPC (18:2) | Lipid | 0.87 (0.81, 0.94) | 2.81 × 10−4 | 3.49 × 10−2 |
PC (O-16:0/18:1)* | Lipid | 0.88 (0.82, 0.94) | 3.32 × 10−4 | 3.60 × 10−2 |
LysoPE (18:2)* | Lipid | 0.88 (0.82, 0.94) | 4.60 × 10−4 | 3.81 × 10−2 |
3-Methyl catechol sulfate (2) | Xenobiotic | 1.14 (1.06, 1.23) | 4.76 × 10−4 | 3.81 × 10−2 |
LysoPC (18:3)* | Lipid | 0.87 (0.81, 0.94) | 4.83 × 10−4 | 3.81 × 10−2 |
Phenylacetylglutamine | Peptide | 0.88 (0.81, 0.95) | 1.11 × 10−3 | 8.04 × 10−2 |
PE (O-18:0/18:2)* | Lipid | 0.89 (0.83, 0.96) | 1.41 × 10−3 | 9.40 × 10−2 |
Serine | Amino acid | 0.89 (0.83, 0.96) | 1.74 × 10−3 | 1.03 × 10−1 |
Androstenediol (3β,17β) disulfate (2) | Lipid | 1.13 (1.05, 1.22) | 1.86 × 10−3 | 1.03 × 10−1 |
2-Hydroxysebacate | Lipid | 0.89 (0.83, 0.96) | 1.89 × 10−3 | 1.03 × 10−1 |
SM (d18:2/23:0, d18:1/23:1, d17:1/24:1)* | Lipid | 0.89 (0.83, 0.96) | 2.31 × 10−3 | 1.13 × 10−1 |
PE (O-18:0/18:1) | Lipid | 0.90 (0.83, 0.96) | 2.41 × 10−3 | 1.13 × 10−1 |
Androsteroid monosulfate (1)* | Lipid | 1.13 (1.04, 1.22) | 2.58 × 10−3 | 1.13 × 10−1 |
12,13-DiHOME | Lipid | 0.89 (0.83, 0.96) | 2.61 × 10−3 | 1.13 × 10−1 |
21-Hydroxypregnenolone disulfate | Lipid | 1.13 (1.04, 1.22) | 2.90 × 10−3 | 1.14 × 10−1 |
LysoPC (18:1) | Lipid | 0.90 (0.83, 0.96) | 3.01 × 10−3 | 1.14 × 10−1 |
SM (d18:1/22:1, d18:2/22:0, d16:1/24:1)* | Lipid | 0.90 (0.84, 0.96) | 3.03 × 10−3 | 1.14 × 10−1 |
3-Ethylcatechol sulfate (2) | Xenobiotic | 1.11 (1.04, 1.20) | 3.34 × 10−3 | 1.14 × 10−1 |
3-Hydroxypyridine glucuronide | Xenobiotic | 1.12 (1.04, 1.20) | 3.47 × 10−3 | 1.14 × 10−1 |
Arachidyl carnitine (C20)* | Lipid | 0.89 (0.82, 0.96) | 3.55 × 10−3 | 1.14 × 10−1 |
S-Methylcysteine sulfoxide | Amino acid | 0.89 (0.83, 0.96) | 3.56 × 10−3 | 1.14 × 10−1 |
PC (18:0/18:2)* | Lipid | 0.90 (0.84, 0.97) | 3.75 × 10−3 | 1.15 × 10−1 |
(2,4 or 2,5)-Dimethylphenol sulfate | Xenobiotic | 1.12 (1.04, 1.20) | 4.09 × 10−3 | 1.15 × 10−1 |
N-Formylanthranilic acid | Amino acid | 0.89 (0.83, 0.96) | 4.09 × 10−3 | 1.15 × 10−1 |
Octadecadienoate (C18:2-DC)* | Lipid | 0.89 (0.83, 0.96) | 4.13 × 10−3 | 1.15 × 10−1 |
Syringol sulfate | Xenobiotic | 1.12 (1.04, 1.21) | 4.23 × 10−3 | 1.15 × 10−1 |
Docosadioate (C22-DC) | Lipid | 0.90 (0.83, 0.97) | 4.77 × 10−3 | 1.24 × 10−1 |
PC (18:2/20:4n6)* | Lipid | 0.90 (0.84, 0.97) | 5.02 × 10−3 | 1.24 × 10−1 |
PE (O-16:0/18:1)* | Lipid | 0.90 (0.84, 0.97) | 5.10 × 10−3 | 1.24 × 10−1 |
PI (18:0/18:1)* | Lipid | 0.90 (0.83, 0.97) | 5.25 × 10−3 | 1.24 × 10−1 |
LysoPC (24:0) | Lipid | 0.90 (0.83, 0.97) | 5.48 × 10−3 | 1.24 × 10−1 |
Hippurate | Xenobiotic | 0.90 (0.83, 0.97) | 5.86 × 10−3 | 1.24 × 10−1 |
SM (d18:2/14:0, d18:1/14:1)* | Lipid | 0.90 (0.84, 0.97) | 5.89 × 10−3 | 1.24 × 10−1 |
Androstenediol (3β,17β) disulfate (1) | Lipid | 1.11 (1.03, 1.20) | 5.99 × 10−3 | 1.24 × 10−1 |
PE (18:2/18:2)* | Lipid | 0.90 (0.84, 0.97) | 5.99 × 10−3 | 1.24 × 10−1 |
Sphinganine-1-phosphate | Lipid | 0.91 (0.85, 0.97) | 6.07 × 10−3 | 1.24 × 10−1 |
PI (18:0/18:2) | Lipid | 0.90 (0.84, 0.97) | 6.18 × 10−3 | 1.24 × 10−1 |
PE (O-16:0/18:2)* | Lipid | 0.90 (0.84, 0.97) | 6.30 × 10−3 | 1.24 × 10−1 |
Glycerophosphoethanolamine | Lipid | 0.91 (0.84, 0.97) | 7.09 × 10−3 | 1.34 × 10−1 |
16α-Hydroxy DHEA 3-sulfate | Lipid | 1.11 (1.03, 1.20) | 7.15 × 10−3 | 1.34 × 10−1 |
SM (d18:1/24:0) | Lipid | 0.91 (0.84, 0.97) | 7.25 × 10−3 | 1.34 × 10−1 |
Undecanedioate (C11-DC) | Lipid | 0.91 (0.84, 0.97) | 8.01 × 10−3 | 1.41 × 10−1 |
Asparagine | Amino acid | 0.91 (0.84, 0.97) | 8.05 × 10−3 | 1.41 × 10−1 |
Androstenediol (3α, 17α) monosulfate (2) | Lipid | 1.11 (1.03, 1.20) | 8.15 × 10−3 | 1.41 × 10−1 |
Catechol glucuronide | Amino acid | 1.10 (1.02, 1.19) | 8.85 × 10−3 | 1.51 × 10−1 |
Pregnenolone sulfate | Lipid | 1.11 (1.03, 1.20) | 9.72 × 10−3 | 1.60 × 10−1 |
4-Guanidinobutanoate | Amino acid | 0.91 (0.85, 0.98) | 9.82 × 10−3 | 1.60 × 10−1 |
LysoPE (O-18:0)* | Lipid | 0.91 (0.84, 0.98) | 9.94 × 10−3 | 1.60 × 10−1 |
LysoPE (18:0) | Lipid | 0.91 (0.84, 0.98) | 1.05 × 10−2 | 1.66 × 10−1 |
Androstenediol (3β,17β) monosulfate (1) | Lipid | 1.11 (1.02, 1.19) | 1.08 × 10−2 | 1.67 × 10−1 |
Sphinganine | Lipid | 0.91 (0.85, 0.98) | 1.10 × 10−2 | 1.67 × 10−1 |
β-Cryptoxanthin | Cofactors/vitamins | 0.91 (0.84, 0.98) | 1.33 × 10−2 | 1.94 × 10−1 |
PE (18:1/18:2)* | Lipid | 0.91 (0.85, 0.98) | 1.34 × 10−2 | 1.94 × 10−1 |
Dehydroepiandrosterone sulfate (DHEA-S) | Lipid | 1.11 (1.02, 1.20) | 1.35 × 10−2 | 1.94 × 10−1 |
Glutamine | Amino acid | 0.91 (0.85, 0.98) | 1.37 × 10−2 | 1.94 × 10−1 |