Fig. 7From: METTL3 depletion contributes to tumour progression and drug resistance via N6 methyladenosine-dependent mechanism in HR+HER2—breast cancerMETTL3 induces HR+HER2− BC apoptosis via the m6A-Bax/caspase-3/-8/-9 pathway. A and B METTL3 knockdown or overexpression influenced the expression levels of caspase proteins as indicated by the western blot assay. C and D BAX expression was depleted upon METTL3 knockdown but enhanced by METTL3 overexpression. E MeRIP with an anti-m6A antibody was performed in MCF-7 cells. The m6A modification on BAX mRNA was depleted upon METTL3 knockdown. F Schematic summarizing the role of METTL3 in modulating HR+HER2− BC progressionBack to article page