Fig. 5

Breast tumour cell composition. A Frequently enriched cell types in breast tumours (red) and normal breast tissue (blue). B Heatmap illustrating cell-type enrichment in healthy adjacent tissue of nine TCGA cancer cohorts. C Abundance of IR events in purified cells. Colours indicate groups of cells belonging to the same family. Dashed red line represent mean number of IR events. Th1/2—T helper 1/2; MSC—mesenchymal stem cell; ly—lymphatic; mv—microvascular; a/cDC—activated/classical dendritic cell; Tcm—T central memory cell; Tem—T effector memory cell; NKT—natural killer T cell; MEP—megakaryocyte–erythroid progenitor cell. ImmuneScore quantifies the enrichment of an immune cell signature including B cells, T cells, DC, eosinophils, macrophages, monocytes, mast cells, neutrophils, and NK cells. StromaScore quantifies the enrichment of a stroma-type cell signature including adipocytes, endothelial cells, and fibroblasts