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Fig. 2 | Breast Cancer Research

Fig. 2

From: Definition of a novel breast tumor-specific classifier based on secretome analysis

Fig. 2

Secretome analysis allowed segregation between breast tumor and juxta-tumor tissues A Ratio between paired tumor and juxta-tumor molecules concentrations. The red line indicates the ratio of 1, meaning that the same analyte concentration was measured in the tumor and in the juxta-tumor supernatants. The molecules were ordered by the median value of the ratio (represented by the green bars). Molecules with less than 5% of in-range detection in juxta-tumors were represented in gray (IL-9, TPO, IL-12p40, TNF-β, TSPL, IL-21). Paired t test on the logged concentrations was performed, and p values were annotated as follow: NS (non-significant): > 0.05; *: ≤ 0.05; **: ≤ 0.01; ***: ≤ 0.001. (Detailed P values are reported in Table S4.) B Projection of the 422 tumors and 422 paired juxta-tumors on the first components of a PCA of the secretome data (after missing data imputation and without IL-9, TPO, IL-12p40, TNF-β, TSLP, IL-21). Confidence ellipses according to the tissue type were calculated from a Gaussian distribution at 95% level. C Bar plots describing the molecule contributions to the PCA components 1 and 2. D IL-16, FGF-2, CCL8, and Leptin concentrations measured in the juxta-tumor (X-axis) and the tumor tissue (Y-axis) supernatants for each patient. The two-dimensional density of the observations was displayed with iso-density contour lines. Regions outside of the detection range were displayed in gray. E Projection of the 422 tumors and 422 paired juxta-tumors on the first components of the same PCA as shown in B, with confidence ellipses according to the tissue type and color coded according to the three groups defined on the secretome-based distance between the tumors and the paired juxta-tumors

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