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Fig. 1 | Breast Cancer Research

Fig. 1

From: Definition of a novel breast tumor-specific classifier based on secretome analysis

Fig. 1

Secretome analysis of human breast tumor and juxta-tumor microenvironment A Schematic view of the experimental design and analysis. Primary breast cancer patients’ tumor tissues and paired non-malignant tissues (n = 422 patients, n = 844 samples) were freshly analyzed as explained in Methods section. Three datasets were generated: secretome analysis, glucose consumption and lactate production, and clinical data. The right panel shows the 55 analytes measured in this analysis. B, C Individual patient secretome concentration in pg/mL (n = 422 patients, except for molecules with technical issues for which samples with missing data were not displayed). All molecules were quantified by Luminex or MSD technologies in supernatants harvested after 24 h of tissue explant culture of juxta-tumor B and tumor tissues. C The molecules were ordered by median in-range concentration in the juxta-tumors. The green bars represent the median values of in-range concentrations. Samples outside of the detection range are displayed in gray. Molecules with less than 5% of in-range detection in juxta-tumors were represented in gray (IL-9, TPO, IL-12p40, TNF-β, TSLP, IL-21)

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