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Table 4 Association of ADBV with serum metabolites associated with childhood BMI Z-score (FDR < 0.20) and association of these metabolites with BMI Z-score

From: Childhood adiposity, serum metabolites and breast density in young women

Metabolite

Superclass

Percent difference in ADBV associated with 10% increase in serum metabolitea

Percent difference in serum metabolites associated with a unit increase in BMI z-scoreb

Δ

95% CI

P-value

Δ

95% CI

P-value

X-16576

Unknown

2.91

1.25, 4.60

6.92E−04

− 13.65

− 21.53, − 4.99

3.01E−03

X-12104

Unknown

3.81

1.24, 6.45

4.06E−03

9.66

3.48, 16.22

2.15E−03

lysine

Amino acid

− 7.68

− 12.76, − 2.31

6.26E−03

3.05

0.50, 5.65

1.98E−02

X-24588

Unknown

− 2.84

− 5.05, − 0.57

1.53E−02

8.18

0.73, 16.19

3.21E−02

7-Methylguanine

Nucleotide

− 5.13

− 9.63, − 0.39

3.57E−02

4.77

1.45, 8.20

5.16E−03

Valine

Amino acid

− 5.28

− 10.01, − 0.31

3.90E−02

4.13

1.65, 6.66

1.20E−03

Homoarginine

Amino acid

− 2.71

− 5.40, 0.06

5.64E−02

7.22

1.63, 13.12

1.16E−02

X-17340

Unknown

− 1.70

− 3.51, 0.14

7.13E−02

28.52

17.89, 40.11

5.17E−08

5alpha-androstan-3alpha,17beta-diol monosulfate (1)

Lipid

0.99

− 0.08, 2.06

7.14E−02

37.90

17.09, 62.41

1.66E−04

N-acetylvaline

Amino acid

− 4.55

− 9.25, 0.39

7.21E−02

3.68

0.63, 6.83

1.87E−02

Glycochenodeoxycholate 3-sulfate

Lipid

− 1.01

− 2.10, 0.10

7.63E−02

− 14.80

− 24.58, − 3.75

1.09E−02

Kynurenine

Amino acid

− 2.72

− 5.76, 0.42

9.10E−02

6.20

1.74, 10.85

6.65E−03

  1. aResults shown for metabolites associated with ADBV at P < 0.10. Estimates are from robust mixed effects multivariable linear regression models including ADBV as the dependent variable; childhood fixed effects – ln(metabolite level) (continuous), BMI z-score (continuous), age at BMI measurement (continuous), treatment group assignment, race (white/nonwhite) and menstrual cycle phase at blood collection (premenarche/luteal/follicular/unknown); adult fixed effects—BMI and BMI2 at breast density (continuous), college graduate (yes/no), duration hormone use (continuous), number live births (0/1 +), current smoker (yes/no); and DISC clinic as a random effect
  2. bEstimates are from robust mixed effects multivariable linear regression models including ln(metabolite level) (continuous) as the dependent variable; childhood fixed effects—BMI z-score (continuous), age at BMI measurement (continuous), treatment group assignment, race (white/nonwhite) and menstrual cycle phase at blood collection (premenarche/luteal/follicular/unknown); and DISC clinic as a random effect