Table 1 List of the quantitative microvessel morphological parameters

NB

Numbers of branch points: defined as any node that is connected to three or more vessel segments

NV

Number of vessel segments

VD

Vessel density: defined as the proportion of vessel area with blood flow over the total area measured

D (mm)

Vessel diameter (D_mean, D_max): defined as two times of the minimum distance between the vessel centerline and the vessel border

τ

Vessel tortuosity (τ_mean, τ_max): Distance metric measures vascular tortuosity

MD

Murray’s deviation: diameter mismatch, defined as the deviation from Murray's law, increases in the vasculature network of malignant tumors

mvFD

Microvessel fractal dimension: A unit-less geometrical feature that is a marker of microvascular complexity

BA (°)

Bifurcation angle: refers to the angle between two daughter vessels