Skip to main content

Table 2 Associations between birthweight and puberty and breast cancer by menopausal and ER status

From: Birthweight, childhood body size, and timing of puberty and risks of breast cancer by menopausal status and tumor receptor subtypes

Characteristic

N

Pre-menopausal breast cancer

Postmenopausal breast cancera

Overall

ER+ 

ER−

Overall

ER+ 

ER−

Cases

HR (95% CI)

Cases

HR (95% CI)

Cases

HR (95% CI)

Cases

HR (95% CI)

Cases

HR (95% CI)

Cases

HR (95% CI)

Birthweight, per 500 g

125,352

1120

1.03 (0.97–1.09)

865

1.03 (0.96–1.09)

255

1.03 (0.92–1.16)

4392

1.02 (0.99–1.05)

3699

1.03 (1.00–1.06)

693

0.97 (0.90–1.04)

Puberty markers, per year

Age at OGS

70,538

710

0.95 (0.89–1.00)

566

0.94 (0.88–1.00)

144

0.98 (0.86–1.11)

3703

0.98 (0.96–1.01)

3104

0.98 (0.95–1.01)

599

1.01 (0.95–1.08)

Age at PHV

70,538

710

0.94 (0.89–1.00)

566

0.94 (0.88–1.01)

144

0.95 (0.83–1.08)

3703

0.99 (0.96–1.02)

3104

0.98 (0.96–1.01)

599

1.01 (0.94–1.08)

  1. Associations were estimated in girls from the Copenhagen School Health Records Register followed from January 1995
  2. CI confidence interval, ER estrogen receptor, HR hazard ratio, OGS onset of the growth spurt, PHV peak height velocity
  3. aAdjusted for use of hormone replacement therapy